Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient. Continuous... read more

Clinical Trials Design Evaluating Sedation in Critically Ill Adults Requiring Mechanical Ventilation

Clinical Trials Design Evaluating Sedation in Critically Ill Adults Requiring Mechanical Ventilation

These recommendations are intended to assist researchers in the design, conduct, selection of endpoints, and reporting of clinical trials involving sedative medications and/or sedation protocols for adult ICU patients who... read more

Percutaneous Dilational Tracheostomy for COVID-19 Patients Requiring Mechanical Ventilation

Percutaneous Dilational Tracheostomy for COVID-19 Patients Requiring Mechanical Ventilation

Patients with COVID-19 who survive the early days of MV experience severe and prolonged respiratory failure. An early modified percutaneous dilational tracheostomy (PDT) was safe for patients and healthcare providers and... read more

RRT in Critically Ill Patients with AKI

RRT in Critically Ill Patients with AKI

Recent evidence has shown that pre-emptive or earlier renal-replacement therapy (RRT) in patients with severe acute kidney injury (AKI) and no urgent indications does not confer clinical benefit. By default, this would imply... read more

The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized... read more

Evolving Changes in Mortality of Critically Ill with COVID-19 Over 8 Months

Evolving Changes in Mortality of Critically Ill with COVID-19 Over 8 Months

Age and mortality rates have declined over the first 8 months of the pandemic. The use of non-invasive respiratory support (NIRS) as the first respiratory support measure was associated with survival, but causal inference... read more

Tocilizumab Use May Be Associated with a Short-term Mortality Benefit

Tocilizumab Use May Be Associated with a Short-term Mortality Benefit

For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required. Its benefits may also lie in reducing the... read more

The Predictive Role of Combined Cardiac and Lung Ultrasound in COVID-19

The Predictive Role of Combined Cardiac and Lung Ultrasound in COVID-19

In hospitalized patients with coronavirus disease 2019, a very limited echocardiographic examination is sufficient for outcome prediction. The addition of echocardiography in patients with high-risk MEWS decreases the rate... read more

NIV After Early Extubation Reduces Total Days Spent on i-MV

NIV After Early Extubation Reduces Total Days Spent on i-MV

Patients recovering from an episode of hypoxemic acute respiratory failure (hARF) may benefit from a weaning strategy based on early extubation followed by immediate noninvasive ventilation (NIV) application. Compared... read more

Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19

Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19

Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. Using data from the Premier Healthcare Database on 181,813... read more

Clinical strategies for implementing lung and diaphragm-protective ventilation

Clinical strategies for implementing lung and diaphragm-protective ventilation

Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm develops atrophy as a consequence of low... read more

Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages

Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages

The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a spectrum of symptoms ranging from mild to critical... read more

A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States

A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States

Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding... read more

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

Sabah in Malaysian Borneo is among the Malaysian states which reported a high number of detected COVID-19 cases during the current pandemic. Due to geographical challenges and limited resources, clinicians developed novel... read more