Loss of Sphingosine 1-Phosphate in Septic Shock is Predominantly Caused by Decreased Levels of HDL

Loss of Sphingosine 1-Phosphate in Septic Shock is Predominantly Caused by Decreased Levels of HDL

Sphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and vascular tone. Serum S1P is progressively reduced in sepsis patients... read more

Incidence, Severity, and Detection of Blood Pressure Perturbations after Abdominal Surgery

Incidence, Severity, and Detection of Blood Pressure Perturbations after Abdominal Surgery

Intraoperative and postoperative hypotension are associated with myocardial and kidney injury and 30-day mortality. Intraoperative blood pressure is measured frequently, but blood pressure on surgical wards is usually measured... read more

Monitoring the Relationship Between Changes in Cerebral Oxygenation and Electroencephalography Patterns During Cardiopulmonary Resuscitation

Monitoring the Relationship Between Changes in Cerebral Oxygenation and Electroencephalography Patterns During Cardiopulmonary Resuscitation

Real-time monitoring of cerebral oxygenation and function during cardiac arrest resuscitation is feasible. Although voltage suppression is the commonest electroencephalography pattern, other distinct patterns exist that may... read more

Can Noninvasive BP Monitoring Replace Arterial Catheter?

Can Noninvasive BP Monitoring Replace Arterial Catheter?

Although its reliability is often questioned, noninvasive blood pressure (NIBP) monitoring with an oscillometric arm cuff is widely used. Indeed, intermittent arm NIBP is the first-line monitoring technique during prehospital... read more

Optimizing Hemodynamic Support in Severe Sepsis and Septic Shock, An Issue of Critical Care Clinics

Optimizing Hemodynamic Support in Severe Sepsis and Septic Shock, An Issue of Critical Care Clinics

Guest Editor Dane Nichols, MD, has assembled a panel of experts focusing on Hemodynamic Support in Septic Shock. Topics include: Oxygen Delivery and Consumption: A Macro-Circulatory Perspective; Mean Arterial Pressure: Therapeutic... read more

ICU Utilization for Patients With Acute Exacerbation of COPD Receiving Noninvasive Ventilation

ICU Utilization for Patients With Acute Exacerbation of COPD Receiving Noninvasive Ventilation

There is wide variability in the rate of ICU utilization for noninvasive ventilation across hospitals. Chronic obstructive pulmonary disease (COPD) patients receiving noninvasive ventilation had similar in-hospital mortality... read more

Acute Right Heart Failure

Acute Right Heart Failure

The right ventricle is often overlooked in critical care in favour of the attention to the left side of the heart. But acute right heart failure is important and today on the podcast we discuss its implications for critical... read more

Less or More Hemodynamic Monitoring in Critically Ill Patients

Less or More Hemodynamic Monitoring in Critically Ill Patients

The use of echocardiography should be initially encouraged in patients with shock to identify the type of shock and to select the most appropriate therapy. The use of more invasive hemodynamic monitoring techniques should... read more

How to Improve Worldwide Early Enteral Nutrition Performance in ICUs?

How to Improve Worldwide Early Enteral Nutrition Performance in ICUs?

Early enteral nutrition (EEN), typically started within 48 h after ICU admission, is recommended to be superior over delayed enteral nutrition and parenteral nutrition. The ESICM Working Group on Gastrointestinal Function... read more

Continuous EEG Monitoring Remains Underused in Critically Ill

Continuous EEG Monitoring Remains Underused in Critically Ill

A retrospective cross-sectional study found that despite the fact that continuing electroencephalography (cEEG) use was associated with lower in-hospital mortality in critically ill patients, cEEG is underutilized. Experts... read more

Rapid Bedside Evaluation of Seizures in the ICU by Listening to the Sound of Brainwaves

Rapid Bedside Evaluation of Seizures in the ICU by Listening to the Sound of Brainwaves

The Ceribell EEG System enabled rapid acquisition of electroencephalography (EEG) in patients at risk for non-convulsive seizures and aided clinicians in their evaluation of encephalopathic ICU patients. The ease of use and... read more

Hemodynamic Monitoring: Invasive and Noninvasive Clinical Application

Hemodynamic Monitoring: Invasive and Noninvasive Clinical Application

Praised by nursing students for its straightforward language and readability, this interdisciplinary reference on bedside hemodynamic monitoring covers the technical aspects of clinical monitoring, including diagnostic and... read more

The Accuracy of Noninvasive Cardiac Output and Pressure Measurements with Finger Cuff

The Accuracy of Noninvasive Cardiac Output and Pressure Measurements with Finger Cuff

The finger cuff method provides a reasonable estimate of CO and blood pressure, which does not meet the criteria for clinical interchangeability with the currently used invasive devices. Finger cuff is an easy-to-use hemodynamic... read more

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

The evidence-based ABCDEF bundle was successfully implemented in seven community hospital ICUs using an interprofessional team model to operationalize the Pain, Agitation, and Delirium guidelines. Higher bundle compliance... read more