Out-of-hours Discharge from ICU, In-hospital Mortality and ICU Readmission Rates

Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. These effects persisted across all definitions of “out of hours” and across healthcare systems in different geographical... read more

Out-of-hours Discharge from ICU, In-hospital Mortality and ICU Readmission Rates

Oxygenate, Ventilate, Do No Harm

Emergency physicians (EPs) are experts in emergent airway management and thus must be confident managing mechanical ventilation. Hospital-wide bed shortages mean that EPs will be managing admitted patients for longer periods... read more

Oxygenate, Ventilate, Do No Harm

Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents

Nonsusceptibility to first-line antibiotics is associated with decreased survival in GNBSIs. DTR is a simple bedside prognostic measure of treatment-limiting coresistance. The Premier Database was analyzed for inpatients... read more

Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock

In injured patients at risk for hemorrhagic shock, the prehospital administration of thawed plasma was safe and resulted in lower 30-day mortality and a lower median prothrombin-time ratio than standard-care resuscitation.... read more

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock

Prolonged Glucocorticoid Treatment is Associated with Improved ARDS Outcomes

Prolonged methylprednisolone treatment accelerates the resolution of ARDS, improving a broad spectrum of interrelated clinical outcomes and decreasing hospital mortality and healthcare utilization. We conducted two sets of... read more

Prolonged Glucocorticoid Treatment is Associated with Improved ARDS Outcomes

Sepsis is a Preventable Public Health Problem

There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public... read more

Sepsis is a Preventable Public Health Problem

Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis

In New York State following a mandate for sepsis care, completion of a sepsis bundle within 1 hour compared with not completing the 1-hour sepsis bundle within 1 hour was associated with lower risk-adjusted in-hospital mortality... read more

Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis

Effect of Decompressive Laparotomy on Organ Function in Patients with Abdominal Compartment Syndrome

Decompressive laparotomy has been advised as potential treatment for abdominal compartment syndrome (ACS) when medical management fails; yet, the effect on parameters of organ function differs markedly in the published literature.... read more

Effect of Decompressive Laparotomy on Organ Function in Patients with Abdominal Compartment Syndrome

Hemophagocytic Lymphohistiocytosis: Potentially Underdiagnosed in ICUs

Overall, 7 out of 9 patients (77.8%) suffering from aHLH remained undiagnosed. Awareness of this life-threatening syndrome, especially in ICUs, should be raised. The inclusion of ferritin into the admission lab panel for... read more

Hemophagocytic Lymphohistiocytosis: Potentially Underdiagnosed in ICUs

Mitochondrial Function in Sepsis

The authors were tasked with developing five specific questions regarding mitochondrial function in sepsis within the context of the Acute Dialysis Quality Initiative 14 (ADQI XIV) meeting held in Bogotá, Colombia, in late... read more

Mitochondrial Function in Sepsis

Positive End-Expiratory Pressure Lower Than the ARDS Network Protocol Is Associated with Higher Pediatric ARDS Mortality

Patients with PARDS managed with lower PEEP relative to FiO2 than recommended by the ARDSNet model had higher mortality. Clinical trials targeting PEEP management in PARDS are needed. This was a multicenter, retrospective... read more

Positive End-Expiratory Pressure Lower Than the ARDS Network Protocol Is Associated with Higher Pediatric ARDS Mortality

Early application of continuous HVHF can reduce sepsis and improve the prognosis of patients with severe burns

Early application of high-volume haemofiltration (HVHF) benefits patients with severe burns, especially for those with a greater burn area (≥ 80% TBSA), decreasing the incidence of sepsis and mortality. This effect may... read more

Early application of continuous HVHF can reduce sepsis and improve the prognosis of patients with severe burns

Operation Timing and 30-Day Mortality After Elective General Surgery

Elective general surgery appears to be comparably safe at any time of the workday, any day of the workweek, and in any month of the year. The binary outcomes of 32,001 elective general surgical patients at the Cleveland Clinic... read more

Operation Timing and 30-Day Mortality After Elective General Surgery

Increasing the Number of Medical Emergency Calls Does Not Improve Hospital Mortality

With adjustment for patient factors, illness, and comorbidities, increased emergency calling rates were not associated with reduced in-hospital mortality. Efforts to increase calling rates do not seem warranted. We studied... read more

Increasing the Number of Medical Emergency Calls Does Not Improve Hospital Mortality

Presenting Symptoms Independently Predict Mortality in Septic Shock

More than one third of patients with septic shock presented to the emergency department with vague symptoms that were not specific to infection. These patients had delayed antibiotic administration and higher risk of mortality... read more

Presenting Symptoms Independently Predict Mortality in Septic Shock

Survival outcomes after prolonged ICU length of stay among trauma patients: The evidence for never giving up

Prolonged intensive care unit length of stay (ICU-LOS) is associated with high mortality for medical and surgical patients. Existing literature suggests that this may not be true for trauma patients.The results reveal that... read more

Survival outcomes after prolonged ICU length of stay among trauma patients: The evidence for never giving up

The Value of 24/7 In-House ICU Staffing 24/7 Intensivist in the ICU

Staffing of high-volume, high-intensity ICUs with 24 × 7 intensivist coverage facilitates the system changes, which allow ICU teams to provide 24 × 7 critical care.... read more

The Value of 24/7 In-House ICU Staffing 24/7 Intensivist in the ICU

Pressure ulcers in ICU patients: Incidence and clinical and epidemiological features

Pressure ulcers in ICU patients: Incidence and clinical and epidemiological features: A multicenter study in southern Brazil. The main objective is to evaluate the incidence and risk factors of pressure ulcers (PU) in adult... read more

Pressure ulcers in ICU patients: Incidence and clinical and epidemiological features