Culture-Negative Severe Sepsis: Nationwide Trends and Outcomes

Culture-Negative Severe Sepsis: Nationwide Trends and Outcomes

CNSS among hospitalized patients is common, and its proportion is on the rise. CNSS is associated with greater acute organ dysfunction and mortality. Having CNSS is an independent predictor of death. Of 6,843,279 admissions... read more

Towards precision medicine for sepsis patients

Towards precision medicine for sepsis patients

Over the last decade it has become clear that the immunological response and clinical course in sepsis patients is too complex to simply regard it as hyperinflammation-induced organ failure. In contrast to the previous belief... read more

Beta-Blockers Linked to Reduced Mortality in HFrEF

Beta-Blockers Linked to Reduced Mortality in HFrEF

Beta-blockers are associated with significantly reduced mortality, but not hospitalizations, in patients with heart failure and reduced ejection fraction (HFrEF) and atrial fibrillation (AF). The researchers found that β-blockers... read more

Adrenomedullin: a marker of impaired hemodynamics in cardiogenic shock

Adrenomedullin: a marker of impaired hemodynamics in cardiogenic shock

Bio-ADM is a valuable prognosticator and marker of impaired hemodynamics in CS patients. High levels of bio-ADM may show shock refractoriness and developing end-organ dysfunction and thus help to guide therapeutic approach... read more

Co-infection is Frequent in Patients Hospitalized with Influenza

Co-infection is Frequent in Patients Hospitalized with Influenza

According to a recent article published online in Intensive Care Medicine, co-infection occurs commonly in patients with influenza-related infections that require intensive care unit (ICU) admission. Influenza infection causes... read more

Severe Adult ARDS Prediction Models

Severe Adult ARDS Prediction Models

Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation. Although the use of ECMO for severe refractory ARDS has markedly increased since... read more

Glutamine, fish oil and antioxidants in critical illness

Glutamine, fish oil and antioxidants in critical illness

We hypothesize that the harmful effect of IMHP compared to HP enteral nutrition in a heterogeneous group of critically ill patients is limited to the medical critically ill patients and mediated by an early increase in (epa... read more

Three-year mortality in 30 day survivors of critical care with AKI

Three-year mortality in 30 day survivors of critical care with AKI

Acute kidney injury was not an independent risk factor for 3-year mortality among 30-day survivors. Increased 3-year mortality among patients with AKI who survive critical illness may not be related to AKI per se, but rather... read more

Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Acute administration of exenatide to comatose patients in the ICU after OHCA is feasible and safe. Exenatide did not reduce neuron-specific enolase levels and did not significantly improve a composite end point of death and... read more

Skeletal muscle quality as assessed by CT-derived skeletal muscle density is associated with 6-month mortality in mechanically ventilated critically ill patients

Skeletal muscle quality as assessed by CT-derived skeletal muscle density is associated with 6-month mortality in mechanically ventilated critically ill patients

Low skeletal muscle quality at ICU admission, as assessed by CT-derived skeletal muscle density, is independently associated with higher 6-month mortality in mechanically ventilated patients. Thus, muscle quality as well... read more

Lower threshold for abdominal aortic aneurysm repair linked to reduced mortality

Lower threshold for abdominal aortic aneurysm repair linked to reduced mortality

The study examined the differences between the threshold of repair and aneurysm-related mortality in England and the United States. The rate of hospitalization due to a ruptured aneurysm and aneurysm-related death was significantly... read more

Low Blood Glucose Levels In Hospitalized Patients Linked To Increased Mortality Risk

Low Blood Glucose Levels In Hospitalized Patients Linked To Increased Mortality Risk

Mortality risk was higher in insulin-treated patients with moderate hypoglycemia (40-70 mg/dL), compared to patients without insulin treatment with similar glucose values.... read more

CDC estimates preventable deaths from 5 leading causes

CDC estimates preventable deaths from 5 leading causes

The federal Centers for Disease Control and Prevention released data naming the five leading causes of death among Americans under age 80 for 2014.... read more

Impella CP Versus Intra-Aortic Balloon Pump in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Impella CP Versus Intra-Aortic Balloon Pump in Acute Myocardial Infarction Complicated by Cardiogenic Shock

At 30 days, mortality in patients treated with either IABP or Impella CP was similar (50% and 46%, respectively, hazard ratio (HR) with Impella CP, 0.96 (95% confidence interval (CI) 0.42 to 2.18; p=0.92).... read more

The impact of extracerebral organ failure on outcome of patients after cardiac arrest

The impact of extracerebral organ failure on outcome of patients after cardiac arrest

In this multicenter cohort, extracerebral organ dysfunction was common in CA patients. Renal failure on admission was the only extracerebral organ dysfunction independently associated with higher ICU mortality.... read more

Sepsis-3 definitions predict ICU mortality in a low-middle-income country

Sepsis-3 definitions predict ICU mortality in a low-middle-income country

The medical records of 957 patients were retrieved from a prospectively collected database. Serum lactate improved accuracy for values higher than 4 mmol/L in the no-dysfunction and septic shock groups.... read more