Long-term Health Consequences of Under- and Over-feeding in PICU

Energy is essential for the treatment and recovery of children admitted to Pediatric Intensive Care Units (PICU). There are significant immediate and long-term health consequences of both under- and over-feeding in this population.... read more

Long-term Health Consequences of Under- and Over-feeding in PICU

Ideas for Future Intensive Care

Progress toward determining the true worth of ongoing practices or value of recent innovations can be glacially slow when we insist on following the conventional stepwise scientific pathway. Moreover, a widely accepted but... read more

Ideas for Future Intensive Care

Pharmacotherapy in Neurointensive Care

Neurointensive care medicine has experienced great advancements and developments of neuromonitoring techniques, allowing a better comprehension of acute brain injury early phase pathological mechanisms and an overall improvement... read more

Pharmacotherapy in Neurointensive Care

How to Deal with Severe Acute Pancreatitis in the Critically Ill

Management of severe acute pancreatitis (SAP) is multimodal with emphasis on monitoring, adequate fluid resuscitation, avoiding prophylactic use of antibiotics, cause-directed procedures or treatment, and organ support. There... read more

How to Deal with Severe Acute Pancreatitis in the Critically Ill

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

Critically ill patients have considerable oxidative stress. Glutamine and antioxidant supplementation may offer therapeutic benefit, although current data are conflicting. In this blinded 2-by-2 factorial trial, we randomly... read more

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

Expanding the Differential for Hypotension in the Pediatric Patient

As many ED practitioners are aware, food allergies are common in the first 2 years of life, with a prevalence cited between 1-10% of the population. Most food allergies are IgE-mediated hypersensitivity reactions. Food protein-induced... read more

Expanding the Differential for Hypotension in the Pediatric Patient

Increased Hospital-Based Physical Rehabilitation and Information Provision After ICU Discharge

Post-ICU hospital-based rehabilitation, including increased physical and nutritional therapy plus information provision, did not improve physical recovery or HRQOL, but improved patient satisfaction with many aspects of recovery.... read more

Increased Hospital-Based Physical Rehabilitation and Information Provision After ICU Discharge

The PICU Handbook

The PICU Handbook is a unique, portable compilation of the information essential for residents and fellows to successfully navigate the modern Level 1 and Level 2 pediatric intensive care unit (PICU). Enhanced by numerous... read more

The PICU Handbook

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality

Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner. 29,615 adults pooled... read more

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality

Patient-important outcomes in randomized controlled trials in critically ill patients

Patient-important outcomes are rarely primary outcomes in RCTs in critically ill patients published in 2013. Among them, mortality accounted for the majority. We promote the use of patient-important outcomes in critical care... read more

Patient-important outcomes in randomized controlled trials in critically ill patients

Nutrition Support for the Critically Ill

This text provides a review of the current knowledge in both the mechanics of nourishing the critically ill and the metabolic and immunological roles nutrients play. In-depth chapters discuss disease-related malnutrition... read more

Nutrition Support for the Critically Ill

How to Improve Worldwide Early Enteral Nutrition Performance in ICUs?

Early enteral nutrition (EEN), typically started within 48 h after ICU admission, is recommended to be superior over delayed enteral nutrition and parenteral nutrition. The ESICM Working Group on Gastrointestinal Function... read more

How to Improve Worldwide Early Enteral Nutrition Performance in ICUs?

Dosing Adjuvant Vitamin C in Critically Ill Patients Undergoing CRRT

We read with great interest the recent letter to Critical Care by Marik and Hooper. Vitamin C is increasingly recognized as a crucial compound to alleviate morbidity in critically ill patients. Vitamin C concentrations, however,... read more

Dosing Adjuvant Vitamin C in Critically Ill Patients Undergoing CRRT

Principles of Fluid Management and Stewardship in Septic Shock

There are only four major indications for fluid administration in the critically ill: resuscitation, maintenance, replacement and nutrition (enteral or parenteral). In this review, a conceptual framework is presented looking... read more

Principles of Fluid Management and Stewardship in Septic Shock

Nutrition in Surgery Podcast

Changing Care to Improve Surgical Outcomes. In this mini-series of six podcasts sponsored by Abbott Nutrition, the DCRI's Paul Wischmeyer, MD, EDIC, welcomes distinguished scientists and clinicians from the U.S. and the U.K.... read more

The Patient, The Whole Patient and Nothing But The Patient

In this short opinion piece, career and consumer advisor Belinda MacLeod-Smith challenges us to consider crucial elements of whole patient care, and how they can be impacted by limiting factors. Caring for someone with ongoing,... read more

The Patient, The Whole Patient and Nothing But The Patient

Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient?

In this multicentre study, we could not demonstrate any difference between Lp299 and CHX used in oral care procedures regarding their impact on colonisation with emerging potentially pathogenic enteric bacteria in the oropharynx... read more

Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient?

Exploring the Potential Effectiveness of Combining Optimal Nutrition With Electrical Stimulation to Maintain Muscle Health in Critical Illness

This article explores the potential role of nutrition and EMS in maintaining muscle health in critical illness. Within this article, we will evaluate fundamental concepts of muscle wasting and evaluate the effects of EMS,... read more

Exploring the Potential Effectiveness of Combining Optimal Nutrition With Electrical Stimulation to Maintain Muscle Health in Critical Illness

Never Underestimate the Simple Things We Do To Our Patients

In this compelling episode, Professor Paul Wischmeyer, shares some of his experiences as a patient in the ICU. Since he was 15 he has endured multiple hospitalizations and ICU stays for his inflammatory bowel disease. This... read more

Never Underestimate the Simple Things We Do To Our Patients

Proton-Pump Inhibitor Prophylaxis in the ICU

Critical illness can disrupt local and systemic mechanisms that protect against upper gastrointestinal bleeding, a condition that may be associated with increased mortality, particularly among patients receiving extracorporeal... read more

Proton-Pump Inhibitor Prophylaxis in the ICU