Postoperative Pulmonary Complications in the ENIGMA II Trial

Respiratory complications remain among the most common and serious adverse outcomes of major surgery. In the Australian and New Zealand Audit of Surgical Mortality, postoperative pneumonia accounted for 44% of infective... read more

Postoperative Pulmonary Complications in the ENIGMA II Trial

Rising Mortality in COVID-19 Patients Supported With ECMO

We aimed to describe practice patterns and outcomes in patients with extracorporeal membrane oxygenation (ECMO) support throughout the coronavirus 2019 (COVID-19) pandemic, with the hypothesis that mortality would improve... read more

Rising Mortality in COVID-19 Patients Supported With ECMO

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Pharmacologic treatment of COVID-19 has continued to evolve since the onset of the pandemic, and yet many questions remain about optimal treatment. Medicine strives to provide evidence-based guidance on treatments, but... read more

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

A Guide to Mechanical Circulatory Support: A Primer for Ventricular Assist Device (VAD) Clinicians

This unique book details a multidisciplinary approach for providers caring for the Mechanical Circulatory Support (MCS) patient. Authors discuss the history of MCS, patient selection, surgical and post-operative care, mobility... read more

A Guide to Mechanical Circulatory Support: A Primer for Ventricular Assist Device (VAD) Clinicians

Extracorporeal Membrane Oxygenation for Adults (Respiratory Medicine)

This new edition presents an evidence-based review of extracorporeal membrane oxygenation (ECMO) for adults, with a particular focus on veno-venous (VV) ECMO. Due to the dramatic impact of COVID-19, the number of institutions... read more

Extracorporeal Membrane Oxygenation for Adults (Respiratory Medicine)

Neuromonitoring in the Neonatal ECMO Patient

Utilization of extraocorporeal membrane oxygenation (ECMO) has become increasingly widespread as a bridging therapy for neonates with severe, reversible respiratory or cardiac diseases. While significant risks remain, due... read more

Neuromonitoring in the Neonatal ECMO Patient

ECMO Retrieval Program Foundation

This book should represent a guideline for launching an extracorporeal membrane oxygenation (ECMO) program. It describes in detail particularities and special features of planning, setting up, developing, structuring and... read more

ECMO Retrieval Program Foundation

Pronation Improves Respiratory Outcomes in Neonates with Respiratory Failure

This study found that 6-hour periods of pronation (lying on the stomach) can improve gas exchange and lung function in neonates (newborn infants) with three types of respiratory failure, without causing any negative effects... read more

Pronation Improves Respiratory Outcomes in Neonates with Respiratory Failure

Time from Infiltrate on Chest Radiograph to VV ECMO in COVID-19 Affects Mortality

Venovenous extracorporeal membrane oxygenation (VV ECMO) has been used to treat severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome; however, patient selection criteria have evolved throughout the... read more

Time from Infiltrate on Chest Radiograph to VV ECMO in COVID-19 Affects Mortality

Association Between Oxygen Desaturation Index and Cardiovascular Disease in Non-Sleepy SDB Subtype

In the Chinese community-dwelling population, non-sleepy sleep-disordered breathing (SDB) was highly prevalent. Oxygen desaturation index (ODI), an easily extracted indicator from a type IV sleep monitor, most strongly reflected... read more

Association Between Oxygen Desaturation Index and Cardiovascular Disease in Non-Sleepy SDB Subtype

Extracorporeal Membrane Oxygenation for Adults

This new edition presents an evidence-based review of extracorporeal membrane oxygenation (ECMO) for adults, with a particular focus on veno-venous (VV) ECMO. Due to the dramatic impact of COVID-19, the number of institutions... read more

Extracorporeal Membrane Oxygenation for Adults

Prone Position in Mechanically Ventilated Patients

The use of prone position (PP) during invasive mechanical ventilation was first reported more than 45 years ago as a mean to improve oxygenation in patients with acute hypoxemic respiratory failure. Improved oxygenation... read more

Prone Position in Mechanically Ventilated Patients

Expert Consensus on PeRcutaneous Cannulation for ECPR

We present inclusion and exclusion criteria and a comprehensive, detailed, generalizable list of best practices for extracorporeal cardiopulmonary resuscitation (ECPR) initiation following refractory out-of-hospital cardiac... read more

Expert Consensus on PeRcutaneous Cannulation for ECPR

CRT-targeted Fluid Resuscitation vs. Lactate-targeted in Septic Shock

Capillary refill time (CRT)-targeted fluid resuscitation in septic shock was not superior to a lactate-targeted one on early fluid administration or fluid balances. However, it was associated with comparable effects on regional... read more

CRT-targeted Fluid Resuscitation vs. Lactate-targeted in Septic Shock

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Among adult ICU patients with severe hypoxemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa). We obtained 1‑year vital status for... read more

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

New WHO Toolkit Focuses on Severe Acute Respiratory Infection

During the early months of the pandemic, it became imperative to share best practices for the care and treatment of patients with SARS CoV-2. This new infectious agent, with potentially new pathogenesis and an unprecedented... read more

New WHO Toolkit Focuses on Severe Acute Respiratory Infection

Closed-loop oxygen control improves oxygen therapy in AHRF patients under high flow nasal oxygen

Closed-loop oxygen control improves oxygen administration in patients with moderate-to-severe AHRF treated with HFNO, increasing the percentage of time in the optimal oxygenation range and decreasing the workload of healthcare... read more

Closed-loop oxygen control improves oxygen therapy in AHRF patients under high flow nasal oxygen

Patients Monitored Using Wearable Monitors Experienced Fewer Unplanned ICU Admissions

Implementation of continuous monitoring of patient vital signs using wearable monitoring technology linked wirelessly to hospital systems was associated with a reduction in unplanned ICU admissions and rapid response team... read more

Patients Monitored Using Wearable Monitors Experienced Fewer Unplanned ICU Admissions

Setting up a Rescue ECLS Program

Extracorporeal life support (ECLS) is a high-risk, lifesaving medical treatment that is typically limited to centers that can support a comprehensive ECLS program. Rescue programs can bridge the gap in care between ECLS centers... read more

Setting up a Rescue ECLS Program

Principles of Critical Care

Quickly and accurately diagnose and treat the critically ill patient with guidance from the field's definitive text. Considered the field's definitive text, Principles of Critical Care offers unmatched coverage of the diagnosis... read more

Principles of Critical Care

tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?

How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more

tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?