The developing kidney: Perinatal aspects and relevance throughout life

The developing kidney: Perinatal aspects and relevance throughout life

Human perinatal nephrology is a very diverse field in medicine, shared—among others—between obstetricians, neonatologists and nephrologists. Extremely low birth weight infants, babies with growth restriction, and specific... read more

Surfactant Therapies for Pediatric ARDS

Surfactant Therapies for Pediatric ARDS

We advocate for well-designed preclinical and explanatory clinical studies to investigate the use of surfactant for pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome. Given the accumulating knowledge... read more

Pulmonary Aeration and Posterior Collapse Assessed by Electrical Impedance Tomography in Healthy Children

Pulmonary Aeration and Posterior Collapse Assessed by Electrical Impedance Tomography in Healthy Children

The aim of this study was to evaluate the changes in the lung aeration estimated by electrical impedance tomography as the end-expiratory lung impedance after anesthesia induction in pediatric patients. This was a prospective,... read more

Sepsis-Associated AKI Risks in the PICU

Sepsis-Associated AKI Risks in the PICU

In children with severe sepsis, the degree of hemodynamic support as measured by the VIS and the presence of fluid overload may identify patients at increased risk of developing severe acute kidney injury (AKI). Children... read more

Nasotracheal Intubation on Postoperative Neonates with Congenital Heart Disease

Nasotracheal Intubation on Postoperative Neonates with Congenital Heart Disease

Nasotracheal intubation (NTI) is feasible and safe in neonatal cardiac surgery. System-level engagement with stakeholders is necessary to change clinical practice. NTI facilitates early SLP evaluation and treatment and significantly... read more

Trends in Time to Extubation for Pediatric Postoperative Cardiac Patients

Trends in Time to Extubation for Pediatric Postoperative Cardiac Patients

In this large, multicenter database study, early extubation rates in postoperative cardiac patients did not significantly change between 2009 and 2018. Centers that performed early extubation more frequently did not have... read more

Machine Learning Model Validation for Prediction of Potential PICU Transfer

Machine Learning Model Validation for Prediction of Potential PICU Transfer

We developed and externally validated a novel machine learning model that identifies ICU transfers in hospitalized children more accurately than current tools. Our model enables early detection of children at risk for... read more

Prevalence of PICS in Mechanically Ventilated Patients with COVID-19

Prevalence of PICS in Mechanically Ventilated Patients with COVID-19

Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental... read more

The Mysterious Vanishing of MIS-C

The Mysterious Vanishing of MIS-C

Whilst the overwhelming majority of Covid-19 infections in healthy children are mild or asymptomatic, the serious risk which remained was of the hyperinflammatory syndrome known as MIS-C (Multi-system Inflammatory Syndrome... read more

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation

Among infants undergoing endotracheal intubation at two Australian tertiary neonatal intensive care units, nasal high-flow therapy during the procedure improved the likelihood of successful intubation on the first attempt... read more

Critically Unwell Child Intubation in the ED

Critically Unwell Child Intubation in the ED

Intubation in the pediatric emergency department is scary stuff. For critically ill children who require intubation, it is rarely practiced outside of the critical care unit. With the centralization of services there are... read more

Science and Practice of Pediatric Critical Care Medicine

Science and Practice of Pediatric Critical Care Medicine

The field of critical care medicine is in the midst of a dramatic change. Technological and scientific advances during the last decade have resulted in a fundamental change in the way we view disease processes, such as sepsis,... read more

Use of ECMO in Acutely Poisoned Pediatric Patients in US

Use of ECMO in Acutely Poisoned Pediatric Patients in US

Extracorporeal Membrane Oxygenation (ECMO) may improve the hemodynamic and metabolic status of poisoned pediatric patients. Persistent hypotension, acidemia/acidosis, and elevated Pao2 after 24 hours of ECMO were associated... read more

Epidemiology and Outcomes of Critically Ill Children at Risk for PARDS

Epidemiology and Outcomes of Critically Ill Children at Risk for PARDS

The Pediatric Acute Lung Injury Consensus Conference “at-risk for pediatric acute respiratory distress syndrome” criteria identify critically ill children at high risk of pediatric acute respiratory distress syndrome... read more