Extubation in the Operating Room After Elective On-pump CABG Surgery

Although immediate extubation in the operating room following on-pump coronary artery bypass graft (CABG) surgery did not show significant differences in ICU or hospital length of stay (LOS), mortality, or ICU readmission... read more

Cytomegalovirus Infection Adverse Impact on ICU Outcomes in COVID-19 Patients

In critically ill patients with SARS-CoV-2 pneumonia, cytomegalovirus (CMV) infection was frequently observed, and associated with increased ICU and hospital mortality. CMV co-infection correlated with a higher incidence... read more

PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections

Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more

Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors

The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more

COVID-19 Omicron: Immunocompromised vs. Non-immunocompromised Patients

Immunocompromised patients admitted to the ICU due to COVID-19 during the omicron period had higher mortality than non-immunocompromised patients. Additionally, immunocompromised patients with COVID-19 had higher mortality... read more

Eosinopenia as a Predictor of Clinical Outcomes in CAP Patients

Contrary to previously published data, our analysis did not demonstrate an association between eosinopenia and increased mortality risk in hospitalized patients with community-acquired pneumonia (CAP), highlighting the complexity... read more

Oral Health Care and VAP in ICU Patients

Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more

Alcohol Consumption Association with the Risk of Bacterial Infection and Pneumonia

Alcohol consumption has a nonlinear J-shaped dose–response association with the risk of acquiring and dying due to bacterial infection and pneumonia, where moderate consumption between one-half and four UK units per day... read more

Mortality Predictor with sPAP in Elderly Critically Ill with Severe COVID-19 Pneumonia

Mortality in general ARDS patients remains high, with many experiencing long-lasting sequelae. Numerous studies have been conducted to identify predictors of mortality in COVID-19 patients, particularly regarding right ventricular... read more

Antibiotic Prophylaxis Effectiveness in Polytrauma Patients

The results indicate that antibiotic prophylaxis has no significant effect on mortality and clinical status compared with placebo or standard care in adult polytrauma patients but may reduce the risk of VAP. However,... read more

Unlocking the Predictive Power of Nutritional Scores in Septic Patients

This study highlights the significant prognostic utility of nutritional status evaluation in septic patients admitted to internal medicine wards. Among the tools evaluated, the mNUTRIC score—likely because of its dual... read more

Unfractionated Heparin May Improve Near-term Survival in ICU Patients with Sepsis Pneumonia

This study found that early administration of heparin, particularly in sufficient doses (Heparin Sodium 5000 units/mL, 1 mL per dose, three times daily (TID)) for more than 7 d, was associated with reduced near-term mortality... read more

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices... read more

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences

Analgosedation and Delirium Practices in Critically Ill Patients

Before the COVID-19 pandemic, the management of analgosedation was characterized by the predominant use of targeted protocols that favored priority on mild and dynamic sedation in critically ill patients. During the pandemic... read more

Prescribing Patterns and Effectiveness of Ceftolozane/Tazobactam in Immunosuppressed Patients

Treatment with Ceftolozane/Tazobactam (C/T) resulted in a high rate of clinical success in this real-world cohort of immunosuppressed patients, despite dosing that frequently deviated from labelled dosing. Pseudomonas... read more

Ventilator Associated Pneumonia in ICU: Identification, Evaluation and Prevention

This study highlights the significant prevalence of Pseudomonas aeruginosa (PA) as a major bacterial pathogen causing ventilator-associated pneumonia (VAP) in ICU patients, with a high detection rate of 71.7% in tested patients,... read more

Early Weaning From Invasive Mechanical Ventilation via HFNO vs. Conventional Weaning in ARF Patients

In patients with resolving acute hypoxemic respiratory failure (ARF), early extubation with high flow nasal oxygen is feasible and provides a better alternative to conventional weaning from invasive mechanical ventilation,... read more

New Insights: Mortality in Nosocomial Lower Respiratory Tract Infections

This multicenter, multinational study conducted in Europe and Latin America sheds light on the clinical landscape of nLRTI, which continues to be an essential issue in the context of critical care. We provide insights... read more

Rapid and Accurate Sepsis Identification Using AI

This study demonstrates that by providing streamlined predictions using CBC+DIFF data without requiring extensive clinical parameters, the AI-CDSS can be seamlessly integrated into clinical workflows, enhancing rapid, accurate... read more

Prolonged vs. Intermittent Infusion of Meropenem For Patients with Severe Infection

Prolonged infusion of meropenem is more effective than intermittent infusion in reducing mortality, improving clinical outcomes, and enhancing microbial eradication, without increasing adverse events. These benefits are... read more

Predictor of Weaning Outcome Using Sonographic Assessment of Post-intubation Laryngeal Obstruction

The study determined that both cuff leak volume and ultrasound-guided LACWD exhibited excellent sensitivity and specificity in predicting clinically significant upper airway blockage post-extubation, with cuff leak volume... read more

Clinical Outcomes of Early Phenotype-Desirable Antimicrobial Therapy for Enterobacterales Bacteremia

This is first study to compare clinical outcomes between patients with E coli, K pneumoniae, K oxytoca, and P mirabilis BSIs receiving early PDAT vs delayed PDAT using DOOR analysis. Receiving early phenotype-desirable... read more