Serum MANF vs. Severity and Prognosis in Community-acquired Pneumonia Patients

This evidence demonstrated that serum mesencephalic astrocyte-derived neurotrophic factor (MANF) is positively associated with scoring criteria and poor prognosis in community-acquired pneumonia (CAP) patients. Serum... read more

Tocilizumab vs. IVIG in Patients with Severe COVID-19 Pneumonia

Severe COVID-19 patients who received IVIG in the early phase of the disease did not show better clinical outcomes in terms of mortality, hospitalization time and intensive care unit admission compared to those who received... read more

Holy Water Not so Holy: Potential Source of Elizabethkingia Pneumonia and Bacteremia in an Immunocompromised Host

This case report highlights that E. anophelis may indeed cause significant infection and should not be considered a contaminant especially in immunosuppressed individuals. The organism originates from water sources and may... read more

Ventilator-associated Pneumonia Pathogenesis: Old and New Mechanisms

Ventilator-associated pneumonia (VAP), defined as a lung infection that occurs in patients after 48 hours on mechanical ventilation, is among the most frequently found nosocomial infections in intensive care units around... read more

Clinical Characteristics and Survival Outcomes of Invasive Pulmonary Aspergillosis Patients

Invasive pulmonary aspergillosis (IPA) is a severe infectious disease caused by Aspergillus spp. It is associated with high mortality, particularly in immunocompromised patients, as well as in those with COVID-19 pneumonia... read more

Severe Adenoviral Infections: Disease Progression and Poor Prognostic Markers

Low hemoglobin, high serum ferritin, and high LDH in the second week are markers of disease progression and poor prognostic markers in severe adenoviral infections, emphasizing further research and targeted interventions. The... read more

Increased Sodium Levels Associated with Ceftriaxone Administration

Serum sodium elevation is considered a frequent manifestation in critically ill patients, with significant clinical outcomes and requiring timely management. This case report suggests a possible association between the... read more

TyG Index And Short-term Mortality in Patients with Cardiogenic Shock

The triglyceride-glucose (TyG) index is significantly associated with short-term mortality in patients with cardiogenic shock (CS) and may serve as a useful biomarker for risk stratification. This retrospective cohort... read more

Promising Prognostic Predictors in Sepsis Patients Using Lactate and Albumin Ratio

Serum Lactate/Albumin ratio and BAR ratio were significantly higher in sepsis and/or septic shock and associated with increased length of hospital stay and increased in-hospital mortality and poor clinical outcome inside... read more

Successful Clearance of Persistent Staphylococcus Aureus Pneumonia Using High-dose Continuous Infusion Cefazolin

High-dose cefazolin (10 g daily), given as a continuous infusion (CI), was able to clear community-acquired methicillin-susceptible Staphylococcus aureus (MSSA) pneumonia while not exhibiting any signs of toxicity or adverse... read more

Prophylactic IV Antibiotics Outcomes in Patients with Acute Severe Brain Injury on Mechanical Ventilation

Among critically ill patients with acute brain injury, prophylactic IV antibiotics were associated with less VAP but not with changes in length of stay, mortality, or neurologic outcomes. Patients with structural brain... read more

Extubation in the Operating Room After Elective On-pump CABG Surgery

Although immediate extubation in the operating room following on-pump coronary artery bypass graft (CABG) surgery did not show significant differences in ICU or hospital length of stay (LOS), mortality, or ICU readmission... read more

Cytomegalovirus Infection Adverse Impact on ICU Outcomes in COVID-19 Patients

In critically ill patients with SARS-CoV-2 pneumonia, cytomegalovirus (CMV) infection was frequently observed, and associated with increased ICU and hospital mortality. CMV co-infection correlated with a higher incidence... read more

PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections

Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more

Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors

The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more

COVID-19 Omicron: Immunocompromised vs. Non-immunocompromised Patients

Immunocompromised patients admitted to the ICU due to COVID-19 during the omicron period had higher mortality than non-immunocompromised patients. Additionally, immunocompromised patients with COVID-19 had higher mortality... read more

Eosinopenia as a Predictor of Clinical Outcomes in CAP Patients

Contrary to previously published data, our analysis did not demonstrate an association between eosinopenia and increased mortality risk in hospitalized patients with community-acquired pneumonia (CAP), highlighting the complexity... read more

Oral Health Care and VAP in ICU Patients

Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more

Alcohol Consumption Association with the Risk of Bacterial Infection and Pneumonia

Alcohol consumption has a nonlinear J-shaped dose–response association with the risk of acquiring and dying due to bacterial infection and pneumonia, where moderate consumption between one-half and four UK units per day... read more

Mortality Predictor with sPAP in Elderly Critically Ill with Severe COVID-19 Pneumonia

Mortality in general ARDS patients remains high, with many experiencing long-lasting sequelae. Numerous studies have been conducted to identify predictors of mortality in COVID-19 patients, particularly regarding right ventricular... read more

Antibiotic Prophylaxis Effectiveness in Polytrauma Patients

The results indicate that antibiotic prophylaxis has no significant effect on mortality and clinical status compared with placebo or standard care in adult polytrauma patients but may reduce the risk of VAP. However,... read more

Unlocking the Predictive Power of Nutritional Scores in Septic Patients

This study highlights the significant prognostic utility of nutritional status evaluation in septic patients admitted to internal medicine wards. Among the tools evaluated, the mNUTRIC score—likely because of its dual... read more