Tag: prognostics
Impact of Frailty on Persistent Critical Illness
Compared to patients without frailty, those with frailty have a higher chance of developing and dying from Persistent Critical Illness (PerCI). Moreover the importance of frailty as a predictor of mortality increases with... read more
Bringing Biological ARDS Phenotypes to the Bedside with Machine-learning-based Classifiers
The identification of distinct phenotypes within heterogeneous disease states is a key component of personalised medicine, enabling enrichment of clinical trials, better prognostication, and delivery of tailored treatments... read more
Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab
Multiple biomarkers prognostic for clinical outcomes were confirmed in COVACTA. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were... read more
Deep RNA Sequencing of ICU Patients with COVID-19
Current upper respiratory tract testing for COVID-19 only determines if the virus is present. Deep RNA sequencing with appropriate computational biology may provide important prognostic information and point to therapeutic... read more
Estimate Death Probabilities of Hospitalized Patients with COVID-19
The Covid-19 pandemic has become a global public health crisis and providing optimal patient care while preventing a collapse of the healthcare system is a principal objective worldwide. Here we describe a formula, requiring... read more
Lipid Mediators in Critically Ill Patients: A Step Towards Precision Medicine
In this review, we provide an overview of the role of fatty acid-derived lipid mediators as endogenous regulators of the inflammatory, anti-inflammatory and pro-resolving response and future directions for use of clinical... read more
Stress Hyperglycemia and Mortality in Subjects With Diabetes and Sepsis
Stress-induced hyperglycemia is a relevant prognostic factor also in the presence of diabetes. Mild-to-moderate stress hyperglycemia is considered a protective reaction to providing fuel for the immune system and brain at... read more
Ethical Considerations About Artificial Intelligence for Prognostication in Intensive Care
New Artificial Intelligence (AI) and machine learning techniques have the potential to improve prognostication in intensive care. However, they require further refinement before they can be introduced into daily practice.... read more
Aid Tool Does Not Help Care Decisions in Prolonged Mechanical Ventilation
Treatment decisions commonly have to be made in intensive care units (ICUs). These decisions are difficult for surrogate decision makers and often lead to decisional conflict, psychological distress, and treatments misaligned... read more
