Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

During the coronavirus disease (COVID-19) global pandemic, urgent strategies to alleviate shortages are required. Evaluation of the feasibility, practicality, and value of drug conservation strategies and therapeutic alternatives... read more

Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

Procedural Sedation in the COVID-19 Era

Resuming procedural sedation services for elective procedures during the COVID-19 pandemic requires unique considerations to ensure safety for patients and providers. Guidelines for resuming these procedures, including timing,... read more

Procedural Sedation in the COVID-19 Era

The use of continuous perineural catheters and other practices to optimize regional anesthesia in COVID-19 patients

As anesthesiologists, we are on the front line of the fight against coronavirus disease (COVID-19), whether in the intensive care unit, operating room, or elsewhere in the hospital. Given the highly contagious nature of the... read more

The use of continuous perineural catheters and other practices to optimize regional anesthesia in COVID-19 patients

How and When to End the COVID-19 Lockdown

Countries around the world are in a state of lockdown to help limit the spread of SARS-CoV-2. However, as the number of new daily confirmed cases begins to decrease, governments must decide how to release their populations... read more

How and When to End the COVID-19 Lockdown

Prevention of Pathogen Transmission During Ultrasound Use in the ICU

The Australasian Society for Ultrasound in Medicine (ASUM) and the Australasian College for Infection Prevention Control (ACIPC) published guidelines on minimum standards for reprocessing/cleaning of ultrasound transducers... read more

Prevention of Pathogen Transmission During Ultrasound Use in the ICU

Prehabilitation May Influence Surgical Morbidity and Mortality During and After the COVID-19 Pandemic

Elective surgeries have been markedly reduced or even halted altogether in countries affected by the COVID-19 pandemic, the scale of which is unprecedented in modern medicine. The pandemic will negatively affect many... read more

Prehabilitation May Influence Surgical Morbidity and Mortality During and After the COVID-19 Pandemic

Provider Burnout and Fatigue During the COVID-19 Pandemic

The novel Coronavirus Disease 2019 (COVID-19) pandemic has resulted in an overall surge in new cases of depression and anxiety and an exacerbation of existing mental health issues, with a particular emotional and physical... read more

Provider Burnout and Fatigue During the COVID-19 Pandemic

COVID-19 Evolving Indications for Intubation

Hypoxemia and tachypnea should not be the sole indications for intubation, but rather a complete clinical assessment including work of breathing, mental status and increasing PaCO2 and/or acidosis. Based on experience... read more

COVID-19 Evolving Indications for Intubation

Is All Oxygen Created The Same?

Oxygen therapy is frequently used in the emergency department for the treatment of hypoxia and respiratory failure and can be delivered in a variety of ways. Conventional oxygen therapy (COT) via nasal cannula is often a... read more

Is All Oxygen Created The Same?

Safe Transfer of the Brain-injured Patient

The document considers recent developments in the management of multiply-injured patients and those with acute ischaemic stroke. Whilst many of the principles of safe transfer are common to all seriously ill patients,... read more

Safe Transfer of the Brain-injured Patient

Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Infection

This interim guidance is for clinicians caring for patients with confirmed 2019 novel coronavirus (2019-nCoV) infection. CDC will update this interim guidance as more information becomes available. There are a limited... read more

Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Infection

Neuroprognostication Practices in Postcardiac Arrest Patients

Neuroprognostic approaches to hypoxic-ischemic encephalopathy vary among physicians and are often not consistent with current guidelines. The overall inconsistency in approaches and deviation from evidence-based recommendations... read more

Neuroprognostication Practices in Postcardiac Arrest Patients

Prognostication with Point-of-Care Echocardiography During Cardiac Arrest (ALS)

This topic was prioritized by the ALS Task Force based on the high prevalence of point-of-care echocardiography during cardiac arrest without recognizing the potential pitfalls for misinterpretation as an adjunct prognostic... read more

Prognostication with Point-of-Care Echocardiography During Cardiac Arrest (ALS)

Guidelines for the Management of Severe TBI

Often, the available evidence is not sufficient to generate guidelines addressing the most critical questions faced by clinicians and patients. Although there have been some major developments in severe traumatic brain... read more

Guidelines for the Management of Severe TBI

An Ethical Claim for Providing Medical Recommendations in PICU

The Declaration of Geneva was recently revised to emphasize patient autonomy and the importance of clinicians sharing medical knowledge. This reflects the welcome evolution of the doctor-patient relationship from one... read more

An Ethical Claim for Providing Medical Recommendations in PICU

SSEP Retains its Value as Predictor of Poor Outcome Following Cardiac Arrest in the Era of Therapeutic Hypothermia

The absence of the somatosensory evoked potential (SSEP) N20 cortical wave remains one of the most reliable early prognostic tools for identifying unfavorable neurologic outcome in the evaluation of patients with severe anoxic-ischemic... read more

SSEP Retains its Value as Predictor of Poor Outcome Following Cardiac Arrest in the Era of Therapeutic Hypothermia

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection

The provision of procalcitonin assay results, along with instructions on their interpretation, to emergency department and hospital-based clinicians did not result in less use of antibiotics than did usual care among patients... read more

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection

How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections?

Bloodstream infection (BSI) is a major cause of death in developed countries and the detection of microorganisms is essential in managing patients. Despite major progress has been made to improve identification of microorganisms,... read more

How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections?

Practical Management of Invasive Candidiasis in Critically Ill Patients

The heterogeneity of this patient population necessitated the creation of a mixed working group comprising experts in clinical microbiology, infectious diseases and intensive care medicine, all chosen on the basis of their... read more

Practical Management of Invasive Candidiasis in Critically Ill Patients

Sustained reduction of catheter-associated bloodstream infections with enhancement of catheter bundle by chlorhexidine dressings over 11 years

The addition of chlorhexidine dressings to all CVC and arterial lines to an ongoing catheter bundle was associated with a sustained 11-year reduction of all catheter-associated bloodstream infections. This large real-world... read more

Sustained reduction of catheter-associated bloodstream infections with enhancement of catheter bundle by chlorhexidine dressings over 11 years

Antibiotics for Sepsis – Finding the Equilibrium

Sepsis is medicine’s last remaining preserve for unrestrained antibiotic prescribing. The Surviving Sepsis Campaign guidelines recommend empirical broad-spectrum therapy within one hour of triage for both sepsis and septic... read more

Antibiotics for Sepsis – Finding the Equilibrium