Tag: research
Life Following Pediatric Septic Shock
Margaret M. Parker, MD, MCCM, and Jerry J. Zimmerman, MD, PhD, FCCM, talk about the trajectory of long-term mortality and significant health-related quality of life disability among children encountering septic shock. This... read more
New Study on Prehospital Airway Control Trial Underway
Emory University Department of Emergency Medicine and Grady Memorial Hospital will take part in a U.S. Department of Defense-funded clinical trial to compare different ways to help people with traumatic injuries breathe. The... read more
Moral Distress in the Health Professions
This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit... read more
Pretreating Transfused Erythrocytes with NO Prevents Pulmonary Hypertension
Researchers at Massachusetts General Hospital (MGH; Boston, USA), Harvard Medical School (HMS; Boston, MA, USA), and other institutions conducted a trial to see if treating stored packed sheep RBCs with NO before transfusion... read more
Could Stress Ulcer Prophylaxis Increase Mortality in High-acuity Patients?
Although considerable uncertainty remains, the inferences from SUP-ICU and PEPTIC are consistent with the hypothesis that proton pump inhibitors (PPIs) increase the risk of death in patients with higher illness severity.... read more
Potential Therapy for Improving Sudden Cardiac Arrest Resuscitation Outcomes
The severity of cardiogenic shock following asystolic cardiac arrest is dependent on the length of cardiac arrest prior to cardiopulmonary resuscitation and is mediated by myocardial stunning resulting from mitochondrial... read more
Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children
A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence... read more
Should We Treat Fever in Critically Ill Patients Without Acute Brain Pathology?
In one of the sessions at #LIVES2019 in Berlin, Prof. Frank Van Haren of Canberra Hospital, Australia, presented findings from the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management... read more
ICU Bloodstream Infections Reduced by 80 Percent
Bloodstream infections acquired in UK Intensive Care Units (ICUs) reduced by 80% between 2007 and 2012, according to research funded by Biomedical Research Centres (BRC). The findings are based on data collected from over... read more
Management of Cardiogenic Shock Complicating Myocardial Infarction – 2019 Update
In general, randomized clinical trials in CS are difficult to perform and only three randomized trials adequately powered to detect differences in clinical outcomes achieved completion of the required number of patients. Based... read more
Health Coaching to Increase Appropriate Inhaler Use in COPD
Health coaching may provide a scalable model that can improve care for people living with chronic obstructive pulmonary disease (COPD). Baseline adherence and inhaler technique were uniformly poor and did not differ by... read more
Sepsis: The Hour-1 Bundle, the Future of Research, and More
Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis. Drs. Parker and Levy go beyond the bundle to talk about... read more
Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats
Local production of aldosterone by its processing enzyme aldosterone synthase within peripheral sensory neurons contributes to ongoing mechanical hypersensitivity during local inflammation via intrinsic activation of neuronal... read more
Wuhan Coronavirus Infections Could Be 30 Times Higher Than Official Total
The number of people infected with a SARS-like form of coronavirus in Wuhan, China could already be more than 30 times higher the the official tally, researchers in Hong Kong have warned. Gabriel Leung, the chair of public... read more
Animal Viruses and Humans, a Narrow Divide: How Lethal Zoonotic Viruses Spill Over and Threaten Us
"To reproduce promiscuously and to wreak havoc wherever they can find a home," this is the sole raison d'être of viruses writes Dr. Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious... read more
Leading EHR System Adopts Bundle to Prevent ICU Delirium
Seminal studies at Vanderbilt University Medical Center over the past two decades by pulmonary and critical care specialist Wes Ely, M.D. and colleagues have spurred ICU delirium research, and the resulting body of evidence... read more
Spillover: Animal Infections and the Next Human Pandemic
The next big human pandemic, the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza, is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event "spillover"... read more
Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in ICUs
Among ICU nurses, an intervention that included education, role-play, and debriefing resulted in a lower prevalence of job strain at 6 months compared with nurses who did not undergo this program. Further research is... read more
When Exercise Comes to the Hospital’s ICUs
Even short hospital ICU stays can cause lasting problems for patients. Can early mobility and exercise help? Apna Kudchadkar still remembers the morning in 2010 that shaped the trajectory of her scientific research. She... read more
Can Cooling Patients Help After a Cardiac Arrest?
The cooling trial, involving nine UK hospitals, is being led by researchers at the University Hospital of Wales, Cardiff. Altogether, 1,900 patients worldwide are part of the trial, called TTM2. Half of patients were... read more
Maternal Risk Modeling in Critical Care
Risk prediction models specific to the maternal critical care population was developed. The models compare favorably against general adult ICU risk prediction models in current use within this population. The aim was to... read more
Vitamin Treatment For Sepsis Fails In Large Trial
Hope for an effective and inexpensive treatment for the deadly condition sepsis has dimmed following results of a major new study. Researchers had hoped that a simple treatment involving infusions of vitamin C, vitamin... read more
