Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their... read more

Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Intubating critically ill patients is a process that requires a well-thought-out, step-by-step plan, specific to each patient. This book teaches the steps necessary to predict, prepare, perform, and provide pre and post-intubation... read more

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Aminoglycosides Impact on Survival Rate and Renal Outcomes in Patients with Urosepsis

The addition of aminoglycosides to beta-lactam therapy in critically ill patients with urosepsis did not significantly improve 30-day survival. Furthermore, aminoglycosides were not associated with worse renal outcomes.... read more

Sepsis Management: PIRO and MODS

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more

Sepsis Management: PIRO and MODS

Septic Shock Metabolic Subgroups and Clinical Outcome

Three metabolic clusters exist in patients with septic shock with most metabolites differing between clusters and lipid species being most influential. Cluster proportions evolved over time with a high metabolite group... read more

Sepsis: Staging and Potential Future Therapies

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical... read more

Sepsis: Staging and Potential Future Therapies

Mortality in Patients with SA-AKI Using the MIMIC-III Database

In this study, we identified critical factors influencing mortality in patients with Sepsis-Induced Acute Kidney Injury (SA-AKI) using the MIMIC-III database. The primary findings of our research, including advanced age,... read more

Fluid Management Impact on Outcomes in Sequential Extracorporeal Support

Sepsis is a life-threatening condition characterized by dysregulated inflammatory responses, often leading to multiple organ dysfunction and high mortality rates. Continuous renal replacement therapy (CRRT) and extracorporeal... read more

Leptin and Linterlukin-6 Relationship and Influence of Mortality in Sepsis

High leptin levels might counteract the adverse prognostic effect of elevated IL-6 on septic mortality. At the same IL-6 level, leptin could predict septic mortality. Leptin might be a protecting factor for men and gender-different... read more

TyG Index And Short-term Mortality in Patients with Cardiogenic Shock

The triglyceride-glucose (TyG) index is significantly associated with short-term mortality in patients with cardiogenic shock (CS) and may serve as a useful biomarker for risk stratification. This retrospective cohort... read more

Promising Prognostic Predictors in Sepsis Patients Using Lactate and Albumin Ratio

Serum Lactate/Albumin ratio and BAR ratio were significantly higher in sepsis and/or septic shock and associated with increased length of hospital stay and increased in-hospital mortality and poor clinical outcome inside... read more

Management of Pediatric Septic Shock with Electrocardiometry

Advanced hemodynamic monitoring with EC, in conjunction with clinical assessment, facilitated a restrictive fluid strategy and reduced the incidence of FO. By closely monitoring hemodynamic parameters and tailoring therapy... read more

TNF-α, PCT, IL-8, and HBP Prognostic Value Combined with APACHE II Score in Sepsis Patients

Serum TNF-α, PCT, IL-8, and HBP levels influenced sepsis patient prognosis, and their combined detection with APACHE II score provided a high predictive value for patient outcomes. Patients were divided into sepsis and... read more

Peritoneal Dialysis in AKI: 20 Years of Experience at a Single Center

Peritoneal dialysis (PD) may be an effective solution for acute kidney injury (AKI) patients, allowing adequate metabolic and fluid control. Age, APACHE score, hepatorenal syndrome and dropout from PD were associated... read more

ICU-acquired Weakness: Critical Illness Myopathy and Polyneuropathy

Critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) are significant complications in intensive care unit (ICU) patients, first identified in the late 20th century. These conditions often present... read more

Reducing Mortality in Critically Ill Patients

This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more

Reducing Mortality in Critically Ill Patients

Adult Critical Care Medicine

This clinical casebook provides a comprehensive yet concise state-of-the-art review of adult critical care medicine. Presented in a case-based format, each case focuses on a scenario commonly encountered with an adult patient... read more

Adult Critical Care Medicine

Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients

The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more

Septic Distributive Shock: Resuscitative Endovascular Balloon Occlusion of the Aorta

Massive distributive shock can lead to total collapse of the cardiopulmonary system with a subsequent need for CPR. Partial REBOA may be a viable resuscitation adjunct in such cases to restore hemodynamics and increase coronary... read more

Mortality Time Frame Variability in Septic Shock Clinical Trials

There was considerable variability in the mortality time frames reported in ICU-based septic shock trials. This variability may lead to under or overestimation of the problem, overlooking the effectiveness of the interventions... read more

Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients

The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more

Total Bilirubin as a Marker for Hemolysis and Outcome in ARDS Patients Treated with vvECMO

Patients with acute respiratory distress syndrome (ARDS), treatment with veno-venous ECMO and a total bilirubin (tBili) plasma concentration over the threshold of 3.6 mg/dl had significantly lower chances of survival, recovery... read more