Early Tracheostomy in Ventilated COVID-19 Patients Reduces VAP Incidence

Tracheostomy can reduce mechanical ventilation (MV) duration, ICU and hospital length of stay (LOS), and ventilator-associated pneumonia (VAP) risk in critically ill patients. The timing of tracheostomy in COVID-19 patients... read more

Septic Shock in the Prehospital Setting

Septic shock (SS) is a potential life-threatening condition in which an early identification and immediate therapy stand out as the main cornerstones to improve survival chance; in this context, emergency medical services... read more

Management of Dysregulated Immune Response in the Critically Ill

Management of Dysregulated Immune Response in the Critically Ill

This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new term introduced by the Sepsis-3 definitions in 2016. In contrast to systemic... read more

Distinct Immune Profiles and Clinical Outcomes in Sepsis Subphenotypes Based on Temperature Trajectories

Sepsis subphenotypes identified using the universally available measurement of body temperature had distinct immune profiles. Hypothermic patients, who had the highest mortality rate, also had the lowest levels of most pro-... read more

Presepsin Does Not Predict Risk of Death in Sepsis Patients Admitted to the ICU

In patients with suspected sepsis admitted to the Intensive Care Unit, presepsin does not accurately predict the risk of in-hospital death, but it can predict a positive microbiological culture. Adult patients were included... read more

Predictive Value of Combined Detection of Serum LGALS3BP and GDF-15 for the Prognosis of ICU Sepsis Patients

Serum LGALS3BP and GDF-15 levels are abnormally elevated in the death group of ICU sepsis patients, suggesting potential application value as prognostic markers for sepsis. The combined use of LGALS3BP and GDF-15 can... read more

Correlation of Serum Albumin Levels With the Severity of Sepsis Among ICU Patients

In the present study, serum albumin level was noted as a reliable predictor of sepsis severity in ICU patients. Lower serum albumin levels were associated with higher SOFA scores, indicating more severe sepsis. This study... read more

Procalcitonin and Neutrophil to Lymphocyte Ratio Trends in ICU Sepsis Patients

Understanding the trends of PCT and NLR concerning the infection source can provide deeper insights into their diagnostic and prognostic capabilities. This comparative analysis of PCT, NLR, and SOFA score trends contributes... read more

Half of Sepsis Patients Face Death Within Two Years

Half of all patients with sepsis admitted to an emergency medical department died within two years, according to Danish researchers investigating factors that could predict outcomes for these patients. Dr. Finn E. Nielsen,... read more

Adult Critical Care Medicine

Adult Critical Care Medicine

This clinical casebook provides a comprehensive yet concise state-of-the-art review of adult critical care medicine. Presented in a case-based format, each case focuses on a scenario commonly encountered with an adult patient... read more

Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy

In this randomized clinical trial of adults in the ICU with septic shock and severe endotheliopathy, infusion of iloprost, 1 ng/kg/min, for 72 hours did not reduce mean daily SOFA scores compared with placebo. In a clinical... read more

Human albumin solution for on-pump cardiac surgery: benefit or burden?

Deidentified individual participant data collected during the HAS FLAIR-II trial (and the data dictionary) will be shared beginning two years after article publication with no end date. These data will be available to... read more

Improving Patient Outcomes: Sepsis Protocols and Rapid Host Response Technologies

Patients come into the emergency department (ED) with symptoms, not diagnoses. That’s when time is of the essence. Clinicians must quickly triage patients and establish an appropriate care pathway to obtain the best possible... read more

Pediatric Critical Care: A Primer for All Clinicians

Pediatric Critical Care: A Primer for All Clinicians

Pediatric critical care is an emotionally and intellectually demanding field of medicine; however, it is at its core the discipline focused on saving and improving the lives of children affected by acute and chronic illnesses,... read more

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more

Functional Dependence Following ICU-treated Sepsis

Sepsis survivorship was associated with a broad range of new impairments and led to functional dependence in around one quarter of patients. Targeted measures are needed to mitigate the burden of this Post-Sepsis-Syndrome... read more

Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early... read more