Tag: sepsis
Plasma Proteome Temporal Changes Associated with Sepsis Mortality
Our proteomics approach revealed significant associations between changes in the plasma proteome within the first days of sepsis and mortality as well as disease severity. We identified and characterised the underlying... read more
Strong Ion Difference to Predict Mortality in Septic Shock: Mortality Prediction Model for Admission and 24-hour Mortality
Stewart's model examines the relationship between the movement of ions across biological membranes and the consequent changes in pH related to modifications in three dependent variables which are the strong ion difference... read more
Shock Indices as Prognostic Indicators: among Sepsis and Septic Shock Patients with and without Comorbidities Presenting to Emergency Department
Almost 30 million people are affected, and 3 million deaths happen every year because of sepsis. According to WHO's (World Health Organization) Global Report on Epidemiology and Burden of Sepsis report 2020, half of the... read more
Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)
This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their... read more
Heart Rate Control in Septic Shock: Echocardiographic Evaluation and Monitoring
Our study demonstrated a modest reduction in heart rate by approximately 10 beats per minute, accompanied by a slower decrease in noradrenaline requirements com-pared to the control group in the overall population. This... read more
Effect on Norepinephrine Administration Timing on Prognosis of Septic Shock Patients
Norepinephrine initiation ≤1 h is associated with lower 28-day mortality in patients with septic shock. Early norepinephrine administration is also associated with a shorter time to achieve MAP ≥65 mmHg, lower 24-h intravenous... read more
Sepsis: Clinical Diagnosis and Treatment
Sometimes our body's reaction to infection can result in damage to internal tissues and organs. Such a condition is referred to as sepsis. Some of the symptoms of sepsis are high fever, increased heart and breathing rate,... read more
An Optimal Antibiotic Selection Framework for Sepsis Patients Using AI
In this work we present OptAB, the first completely data-driven online-updateable antibiotic selection model based on Artificial Intelligence (AI) for Sepsis patients accounting for side-effects. OptAB performs an iterative... read more
Personalized Therapies in ARDS
Acute respiratory distress syndrome (ARDS) can result from a variety of clinical conditions, causing lung injury either directly through local inflammation or indirectly because of systemic inflammatory mediators ARDS is... read more
Personalizing Beta-blockade in Septic Shock
Clinical trials provide only part of the necessary framework for clinical decision-making. In practice, a detailed understanding of each patient’s hemodynamic profile is essential. We believe that the echocardiography-guided... read more
Lymphocyte Count Trajectories Associated with Prognosis of Sepsis Patients
Three distinct lymphocyte trajectories were identified in sepsis patients using GBTM. Trajectory 3 was a strong predictor of 7-day and 28-day mortality, while Trajectory 1 was associated with early death. These findings... read more
Mechanical Ventilation Timing in Sepsis
A recent study by Dr. Kim and colleagues examined the association between the timing of mechanical ventilation (MV) and clinical outcomes in ICU patients with sepsis. The study included 2440 adult sepsis patients from... read more
Outcomes of Older Adults With Sepsis at Admission to an ICU
Our study suggests that treating older adults with therapies recommended by the Surviving Sepsis Campaign may improve outcomes in this age group, although mortality remains high for older adults with sepsis. In addition,... read more
Early Tracheostomy in Ventilated COVID-19 Patients Reduces VAP Incidence
Tracheostomy can reduce mechanical ventilation (MV) duration, ICU and hospital length of stay (LOS), and ventilator-associated pneumonia (VAP) risk in critically ill patients. The timing of tracheostomy in COVID-19 patients... read more
Septic Shock in the Prehospital Setting
Septic shock (SS) is a potential life-threatening condition in which an early identification and immediate therapy stand out as the main cornerstones to improve survival chance; in this context, emergency medical services... read more
