Tag: sepsis
Stress Hyperglycemia and Mortality in Subjects With Diabetes and Sepsis
Stress-induced hyperglycemia is a relevant prognostic factor also in the presence of diabetes. Mild-to-moderate stress hyperglycemia is considered a protective reaction to providing fuel for the immune system and brain at... read more
Mortality Outcomes with Hydroxychloroquine and Chloroquine in COVID-19
No benefit of hydroxychloroquine or chloroquine on the survival of COVID-19 patients found. For hydroxychloroquine, the confidence interval is compatible with increased mortality or negligibly reduced mortality. Findings... read more
VA-ECMO to Rescue Sepsis-induced Cardiogenic Shock
Patients with sepsis-induced cardiomyopathy with cardiogenic shock have a high mortality. This study assessed venoarterial extracorporeal membrane oxygenation (VA-ECMO) support for sepsis-induced cardiogenic shock refractory... read more
Shedding Light on a Hidden Source of Septic Shock with POCUS
Septic shock has a high mortality rate, estimated to be higher than 40% [1], increasing as time passes without appropriate treatment. Hence, correct diagnosis of the cause of sepsis is essential to provide correct antibiotic... read more
Sepsis and the Obesity Paradox: Size Matters in More Than One Way
Our retrospective analysis suggests that although patient size (i.e., body mass index) is a predictor of in-hospital death among all-comers with sepsis—providing further evidence to the obesity paradox—it adds that illness... read more
Sepsis and COVID-19: Perspectives From a Sepsis Coordinator
Coronavirus disease 2019 (COVID-19) has brought difficulties and disruptions to all corners of the world. As a sepsis coordinator, I can attest that the scientific and healthcare community in the United States has been particularly... read more
Scvo2 in Sepsis: A Measurement Provided by Respiratory Care Practitioners
When treating patients with sepsis, intensive care unit (ICU) and emergency department clinicians have learned that improved outcomes occur when staff members work together as a team. This article outlines the value of central... read more
Which One is Better? Chlorhexidine-impregnated Sponge or Chlorhexidine Gel Dressing
A similar infection risk for gel-dress and sponge-dress. Gel-dress showed fewer dressing disruptions. Concomitant use of CHG for skin disinfection and CHG-impregnated dressing may significantly increase contact dermatitis. A... read more
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more
Critical Care and Hospitalist Medicine Made Ridiculously Simple
A fundamental and thorough guide to the treatment of hospitalized patients in critical care situations, "Critical Care and Hospitalist Medicine Made Ridiculously Simple" provides both introductory information as well as a... read more
What’s the Difference Between COVID-19 Tests?
The COVID-19 pandemic, tests, treatments, and outlook, continue to be front and center in the news, along with other urgent issues taking place across the country. Viral sepsis is the number one complication related to... read more
Biomarkers of Sepsis: Time for a Reappraisal
The precise roles of most biomarkers in the management of septic patients have not been well defined, and of the many biomarkers that have been studied, only a few have been evaluated in large or repeated studies. As... read more
AKI in Critically Ill Patients with COVID-19
Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... read more
An Evidence-Based Approach to Pressors in Shock
The evaluation and treatment of patients with cardiovascular shock is a cornerstone of emergency care. Unfortunately, the literature behind the use of vasoactive medications in cardiovascular shock is inconsistent. A Cochrane... read more
Are Phenotypes a Magic Bullet for Sepsis?
There's a constant battle in medicine between practice styles—standardization and customization. Standardization is order sets and doing the same thing for every patient every time because it (hopefully) delivers better... read more
Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis
There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more
Broad Spectrum Vasopressors
We propose the notion of "broad spectrum vasopressors" wherein patients with septic shock are started on multiple vasopressors with a different mechanism of action simultaneously while the vasopressor sensitivity is assessed.... read more
Can COVID-19 Cause Sepsis? Coronavirus Disease and Sepsis Relationship
On January 30th, the World Health Organization declared the 2019 Novel Coronavirus (SARS-CoV-2) a global health emergency, declaring it an "unprecedented outbreak." While the fears of a COVID-19 pandemic are legitimate,... read more
Surviving Sepsis Campaign Guidelines on the Management of Critically Ill Adults with COVID-19
The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. The novel severe acute respiratory syndrome coronavirus... read more
Focus on Clinical Trial Interpretation
In a recently published meta-epidemiological study of 604 randomised clinical trials (RCTs) published between 1977 and 2018 from 53 Cochrane systematic reviews in critical care, less than 7% of the RCTs had overall low risk... read more
Epinephrine Challenge in Sepsis: An Empiric Approach to Catecholamines
The critical care world is obsessed with fluid. Meanwhile, little attention has been given to the concepts of vasopressor responsiveness and vasopressor challenge. This is a missed opportunity, because vasopressor challenges... read more
Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock
A 2020 randomized trial reported no difference in duration of time alive and free of vasopressor administration at 7 days among intensive care unit (ICU) patients with septic shock assigned to vitamin C, thiamine, and hydrocortisone... read more
