Sepsis and the Obesity Paradox: Size Matters in More Than One Way

Sepsis and the Obesity Paradox: Size Matters in More Than One Way

Our retrospective analysis suggests that although patient size (i.e., body mass index) is a predictor of in-hospital death among all-comers with sepsis—providing further evidence to the obesity paradox—it adds that illness... read more

Sepsis and COVID-19: Perspectives From a Sepsis Coordinator

Sepsis and COVID-19: Perspectives From a Sepsis Coordinator

Coronavirus disease 2019 (COVID-19) has brought difficulties and disruptions to all corners of the world. As a sepsis coordinator, I can attest that the scientific and healthcare community in the United States has been particularly... read more

Scvo2 in Sepsis: A Measurement Provided by Respiratory Care Practitioners

Scvo2 in Sepsis: A Measurement Provided by Respiratory Care Practitioners

When treating patients with sepsis, intensive care unit (ICU) and emergency department clinicians have learned that improved outcomes occur when staff members work together as a team. This article outlines the value of central... read more

Which One is Better? Chlorhexidine-impregnated Sponge or Chlorhexidine Gel Dressing

A similar infection risk for gel-dress and sponge-dress. Gel-dress showed fewer dressing disruptions. Concomitant use of CHG for skin disinfection and CHG-impregnated dressing may significantly increase contact dermatitis. A... read more

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS

In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more

Critical Care and Hospitalist Medicine Made Ridiculously Simple

Critical Care and Hospitalist Medicine Made Ridiculously Simple

A fundamental and thorough guide to the treatment of hospitalized patients in critical care situations, "Critical Care and Hospitalist Medicine Made Ridiculously Simple" provides both introductory information as well as a... read more

What’s the Difference Between COVID-19 Tests?

The COVID-19 pandemic, tests, treatments, and outlook, continue to be front and center in the news, along with other urgent issues taking place across the country. Viral sepsis is the number one complication related to... read more

Biomarkers of Sepsis: Time for a Reappraisal

Biomarkers of Sepsis: Time for a Reappraisal

The precise roles of most biomarkers in the management of septic patients have not been well defined, and of the many biomarkers that have been studied, only a few have been evaluated in large or repeated studies. As... read more

AKI in Critically Ill Patients with COVID-19

AKI in Critically Ill Patients with COVID-19

Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... read more

An Evidence-Based Approach to Pressors in Shock

An Evidence-Based Approach to Pressors in Shock

The evaluation and treatment of patients with cardiovascular shock is a cornerstone of emergency care. Unfortunately, the literature behind the use of vasoactive medications in cardiovascular shock is inconsistent. A Cochrane... read more

Are Phenotypes a Magic Bullet for Sepsis?

Are Phenotypes a Magic Bullet for Sepsis?

There's a constant battle in medicine between practice styles—standardization and customization. Standardization is order sets and doing the same thing for every patient every time because it (hopefully) delivers better... read more

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more

Broad Spectrum Vasopressors

Broad Spectrum Vasopressors

We propose the notion of "broad spectrum vasopressors" wherein patients with septic shock are started on multiple vasopressors with a different mechanism of action simultaneously while the vasopressor sensitivity is assessed.... read more

Can COVID-19 Cause Sepsis? Coronavirus Disease and Sepsis Relationship

Can COVID-19 Cause Sepsis? Coronavirus Disease and Sepsis Relationship

On January 30th, the World Health Organization declared the 2019 Novel Coronavirus (SARS-CoV-2) a global health emergency, declaring it an "unprecedented outbreak." While the fears of a COVID-19 pandemic are legitimate,... read more