Tag: sepsis
Vitamin C for Sepsis Suffers a Setback. Or a Step-Forward. It’s Complicated
The CITRIS-ALI study found no difference in primary outcomes among patients with sepsis treated with vitamin C versus placebo. But there was a difference in a secondary outcome - overall mortality. When it comes to sepsis... read more
Effect of Vitamin C Infusion on Organ Failure in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and Acute Respiratory Distress Syndrome (ARDS), a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers... read more
Candida Bloodstream Infection Under Veno-arterial ECMO Therapy
Cavayas et al. recently described invasive fungal infections in patients under extra-corporeal membrane oxygenation (ECMO) of the Extracorporeal Life Support Organization registry. They found a 1.2% prevalence of Candida... read more
Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality
Overall, quick Sequential Organ Failure Assessment score outperforms systemic inflammatory response syndrome in predicting sepsis outcome, but quick Sequential Organ Failure Assessment score has relative strengths/weaknesses... read more
Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Sepsis
Among patients with severe manifestations of sepsis, initiation of empirical antimicrobial therapy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation. Of 3,164 participants... read more
Refractory Septic Shock: Our Pragmatic Approach
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such... read more
Neonatal Early-Onset Sepsis Evaluation
Twelve years ago, we began a National Institutes of Health–funded study of neonatal early-onset sepsis (EOS) whose goal was to develop multivariate predictive models that could be used by clinicians to evaluate a newborn’s... read more
Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes
Diaphragm atrophy developing during mechanical ventilation strongly impacts clinical outcomes. Targeting an inspiratory effort level similar to that of healthy subjects at rest might accelerate liberation from ventilation.... read more
The Complex Kinetics of Blood Endocan During the Time Course of Sepsis and ARDS
This study highlights the kinetics of endocan in severe sepsis and acute respiratory distress syndrome (ARDS), thus helping to understand the apparently conflicting results observed in the literature. However, the interpretability... read more
Parenteral Anticoagulation Not Associated with Reduced Risk of Ischemic Stroke Among Patients with Atrial Fibrillation During Sepsis
Among patients with Atrial Fibrillation (AF) during sepsis, parenteral anticoagulation was not associated with reduced risk of ischemic stroke and was associated with higher bleeding rates. Of 113,511 patients hospitalized... read more
Beyond Ventilator-induced Diaphragm Dysfunction
Respiratory muscles are essential to ensure the vital function of breathing. The diaphragm is a unique respiratory muscle, because it contracts throughout the individual's life span without resting, not even during sleep.... read more
Early Norepinephrine Has Potential for Septic Shock
Standard sepsis algorithms have suggested completing a fluid bolus before starting vasopressors in patients with septic shock, but multiple observational trials have shown an association between early vasopressor use and... read more
Adjunctive Corticosteroid Treatment in Septic Shock
Interest in the role of the adrenal cortex in the recovery from an infection dates back nearly 100 yr. More than six decades of research on the role of corticosteroid supplementation as an adjunctive treatment for sepsis... read more
Effect of a Sepsis Educational Intervention on Hospital Stay
Adherence to a bundle strategy is low following an educational intervention. However, when patients are managed after instruction in guideline recommendations, hospital stay may be significantly reduced. The main cause... read more
Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care
Randomized clinical trials (RCTs) are conducted to guide clinicians' selection of therapies for individual patients. Currently, RCTs in critical care often report an overall mean effect and selected individual subgroups.... read more
Identification of Subclasses of Sepsis that Showed Different Clinical Outcomes and Responses to Amount of Fluid Resuscitation
Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts of fluid resuscitation.... read more
More Precise Sepsis Therapy with Distinct Clinical Phenotypes
In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, and simulations suggested these phenotypes may... read more
Epidemiology of Sepsis and Septic Shock in Critical Care Units
A comparison between sepsis-2 and sepsis-3 populations using a national critical care database. In an ICU database, compared with Sepsis-2, Sepsis-3 identifies a similar sepsis population with 92% overlap and much smaller... read more
