Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

ARDS Predictors in ICU Patients with Sepsis Using Dynamic Immune Indicator Changes

This study underscores the pivotal role of dynamic immune indicator changes in predicting acute respiratory distress syndrome (ARDS) development among ICU sepsis patients. By incorporating immune cell and immunoglobulin dynamics... read more

Alcohol Consumption Association with the Risk of Bacterial Infection and Pneumonia

Alcohol consumption has a nonlinear J-shaped dose–response association with the risk of acquiring and dying due to bacterial infection and pneumonia, where moderate consumption between one-half and four UK units per day... read more

Pre-ICU Statin Use, AKI and in Hospital Mortality in Sepsis Patients

Pre-ICU statin therapy is associated with a lower risk of acute kidney injury (AKI), and improved in-hospital survival among obese patients with sepsis, suggesting its potential role as a protective measure in this high-risk... read more

The Triglyceride Glucose Index and Delirium Risk in Sepsis Patients

The triglyceride glucose (TyG) index represents a straightforward and efficacious instrument for nursing staff to ascertain the likelihood of delirium in patients with sepsis during the routine monitoring of their condition.... read more

Factors Influencing the Mortality of Patients with Subarachnoid Hemorrhage in the ICU

Spontaneous subarachnoid hemorrhage (SAH) is a prevalent condition for those between the ages of 50 and 60 years, with a high mortality rate in severe cases. The findings of this study indicate that a history of loss... read more

Epidemiology of Myocardial Injury in Trauma Patients

Pathological Troponin concentration elevation occurs in 7% of all trauma patients and it identifies the seriously injured high-risk cohort with worse outcomes than expected based on injury severity. The timing of the... read more

Fungal Infections Surveillance and Prevention in the NICU

It was determined that colonization and development of invasive mycoses among newborns are most often caused by Candida sp., while the detection of filamentous fungi remains sporadic. The etiological role of Malassezia... read more

Prognostic Predictor Using Lactate-to-Albumin Ratio in Patients with Cirrhosis and Sepsis

Lactate-to-albumin ratio (LAR) is strongly associated with poor prognosis in patients with cirrhosis and sepsis. LAR is a promising prognostic marker that provides clinicians with a simple and effective tool for risk... read more

Unlocking the Predictive Power of Nutritional Scores in Septic Patients

This study highlights the significant prognostic utility of nutritional status evaluation in septic patients admitted to internal medicine wards. Among the tools evaluated, the mNUTRIC score—likely because of its dual... read more

Dynamic Nomogram for AKI Prediction in ICU Patients with AHF

After strict screening, 1338 patients with acute heart failure (AHF) were included in the derivation set, and 3,129 in the validation set. Sepsis, use of human albumin, age, mechanical ventilation, aminoglycoside administration,... read more

Risk Factors for Impairments in Quality of Life and Activities of Daily Living in Survivors of Critical Illness

This systematic review was able to identify that survivor of critical illnesses experienced changes in worsening quality of life, with impairment also in their functionality in terms of basic and instrumental activities of... read more

Unfractionated Heparin May Improve Near-term Survival in ICU Patients with Sepsis Pneumonia

This study found that early administration of heparin, particularly in sufficient doses (Heparin Sodium 5000 units/mL, 1 mL per dose, three times daily (TID)) for more than 7 d, was associated with reduced near-term mortality... read more

Predicting MODS in Trauma-induced Sepsis with Machine Learning Models

The nomogram and machine learning models provide enhanced predictive accuracy for multiple organ dysfunction syndrome (MODS) in trauma-induced sepsis patients compared to traditional scoring systems. These tools, accessible... read more

Mental Health in the First Year After ICU-treated Sepsis

Existing data on the prevalence of mental health impairments (MHI) following sepsis and intensive care are based predominantly on self-reported symptoms assessed by using questionnaires, small sample sizes, and clinically... read more

Association Between the Lactate-to-Albumin Ratio (LAR) Index and AKI Risk in Critically Ill Patients with Sepsis

Lactate-to-albumin ratio (LAR) is an emergency predictive indicator of sepsis-related mortality. An elevated LAR is associated with poor outcomes in critically ill patients. However, its predictive value for acute kidney... read more

Which Antimicrobial Treatment for Patients with Bloodstream Infection During ECMO Support?

Enterococcus sp. was incriminated in about a third of BSI among patients with ECMO support. High appropriateness would only be obtained with piperacilline/tazobactam or carbapenems in association with vancomycin while 3rd... read more

Unlocking the Predictive Power of Nutritional Scores in Septic Patients

The study highlights the mNUTRIC score's practicality and reliability in assessing nutritional and inflammatory risks in septic patients, particularly in non-ICU settings. These findings suggest its potential utility... read more

Cumulative Fluid Balance During the First Three ICU Days in Septic Patients with Heart Failure

In septic patients with HFpEF, positive fluid balance of CFB-day1 might improve the prognosis of patients. However, from the second day, fluid overload was associated with poor prognosis. Therefore, we propose that on... read more

Prescribing Patterns and Effectiveness of Ceftolozane/Tazobactam in Immunosuppressed Patients

Treatment with Ceftolozane/Tazobactam (C/T) resulted in a high rate of clinical success in this real-world cohort of immunosuppressed patients, despite dosing that frequently deviated from labelled dosing. Pseudomonas... read more

VEGFR1 Genetic Regulation During Sepsis and Association with ARDS Susceptibility

We identified biologically relevant protein quantitative trait loci (pQTLs) of vascular endothelial growth factor receptor 1 (VEGFR1) levels during sepsis in TCF20 and identified CYP2D6 as the gene more biologically implicated.... read more

Rapid and Accurate Sepsis Identification Using AI

This study demonstrates that by providing streamlined predictions using CBC+DIFF data without requiring extensive clinical parameters, the AI-CDSS can be seamlessly integrated into clinical workflows, enhancing rapid, accurate... read more