Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management

A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall... read more

Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management

Failure to Rescue in ALF

The concept of failure to rescue has been used to measure the quality of care for complications developed following surgery. In patients with acute liver failure (ALF), the concept of failure to rescue highlights the... read more

Recent Advances in Severe Sepsis and Septic Shock Management

This review highlights recent advances in the treatment of severe sepsis and septic shock, emphasizing new strategies aimed at improving overall survival and reducing mortality in this patient population. Despite years... read more

Methylprednisolone vs. Hydrocortisone in Septic Shock Patients

Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more

Assessing the Risk of Poor Clinical Outcomes in Preterm Neonates with Late-onset Sepsis

A predictive calculator for assessing the risk of poor clinical outcomes in preterm neonates with late-onset sepsis (LOS) has been developed. By leveraging readily available clinical data at the time of blood culture collection,... read more

Machine Learning Model for Predicting Acute Pancreatitis Mortality in the ICU

Machine learning model has been proved to be superior to existing prediction scores for mortality prediction of Acute Pancreatitis (AP). The use of most of previous ML models is limited in clinical practice, mainly due... read more

Sepsis Management in Resource-limited Settings

This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More... read more

Sepsis Management in Resource-limited Settings

Predicting SA-AKI Mortality Using XGBoost Algorithm

The integration of advanced techniques with the XGBoost algorithm yielded a highly accurate and interpretable model for predicting Sepsis-Associated Acute Kidney Injury (SA-AKI) mortality across diverse populations. It... read more

Clinical Efficacy of Nafamostat Mesylate-assisted CRRT Therapy in SA-AKI Patients

Nafamostat Mesylate (NM)-assisted continuous renal replacement therapy (CRRT) therapy significantly improves the therapeutic efficacy of patients with sepsis-associated acute kidney injury (SA-AKI). This combined approach... read more

Impact of Short-Acting Beta-Blockers on the Outcomes of Septic Shock Patients

In patients with septic shock, short-acting beta-blockers may improve survival and reduce new-onset tachyarrhythmias. However, these findings were based on low certainty evidence and given ongoing concerns regarding adverse... read more

Thiamine and Ascorbic Acid in Sepsis and Septic Shock

Exploring the individual and synergistic effects of ascorbic acid and thiamine on key pathways implicated in sepsis pathophysiology has not yielded unequivocal evidence supporting their use without concomitant corticosteroids. Heterogeneity... read more

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

ARDS Predictors in ICU Patients with Sepsis Using Dynamic Immune Indicator Changes

This study underscores the pivotal role of dynamic immune indicator changes in predicting acute respiratory distress syndrome (ARDS) development among ICU sepsis patients. By incorporating immune cell and immunoglobulin dynamics... read more

Alcohol Consumption Association with the Risk of Bacterial Infection and Pneumonia

Alcohol consumption has a nonlinear J-shaped dose–response association with the risk of acquiring and dying due to bacterial infection and pneumonia, where moderate consumption between one-half and four UK units per day... read more

Pre-ICU Statin Use, AKI and in Hospital Mortality in Sepsis Patients

Pre-ICU statin therapy is associated with a lower risk of acute kidney injury (AKI), and improved in-hospital survival among obese patients with sepsis, suggesting its potential role as a protective measure in this high-risk... read more

The Triglyceride Glucose Index and Delirium Risk in Sepsis Patients

The triglyceride glucose (TyG) index represents a straightforward and efficacious instrument for nursing staff to ascertain the likelihood of delirium in patients with sepsis during the routine monitoring of their condition.... read more

Factors Influencing the Mortality of Patients with Subarachnoid Hemorrhage in the ICU

Spontaneous subarachnoid hemorrhage (SAH) is a prevalent condition for those between the ages of 50 and 60 years, with a high mortality rate in severe cases. The findings of this study indicate that a history of loss... read more

Epidemiology of Myocardial Injury in Trauma Patients

Pathological Troponin concentration elevation occurs in 7% of all trauma patients and it identifies the seriously injured high-risk cohort with worse outcomes than expected based on injury severity. The timing of the... read more

Fungal Infections Surveillance and Prevention in the NICU

It was determined that colonization and development of invasive mycoses among newborns are most often caused by Candida sp., while the detection of filamentous fungi remains sporadic. The etiological role of Malassezia... read more

Prognostic Predictor Using Lactate-to-Albumin Ratio in Patients with Cirrhosis and Sepsis

Lactate-to-albumin ratio (LAR) is strongly associated with poor prognosis in patients with cirrhosis and sepsis. LAR is a promising prognostic marker that provides clinicians with a simple and effective tool for risk... read more

Unlocking the Predictive Power of Nutritional Scores in Septic Patients

This study highlights the significant prognostic utility of nutritional status evaluation in septic patients admitted to internal medicine wards. Among the tools evaluated, the mNUTRIC score—likely because of its dual... read more

Dynamic Nomogram for AKI Prediction in ICU Patients with AHF

After strict screening, 1338 patients with acute heart failure (AHF) were included in the derivation set, and 3,129 in the validation set. Sepsis, use of human albumin, age, mechanical ventilation, aminoglycoside administration,... read more