Similar Metabolic, Innate Immunity, and Adipokine Profiles in Adult and Pediatric Sepsis vs. SIRS

Similar Metabolic, Innate Immunity, and Adipokine Profiles in Adult and Pediatric Sepsis vs. SIRS

Sepsis presents with similar profiles in adult and pediatric patients, characterized by enhanced inflammatory hormonal response and by repressed innate immunity, metabolism, and myocardial contractility. These features early... read more

Clinician Perception of a Machine Learning–Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock

Clinician Perception of a Machine Learning–Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock

In general, clinical perceptions of Early Warning System 2.0 were poor. Nurses and providers differed in their perceptions of sepsis and alert benefits. These findings highlight the challenges of achieving acceptance of predictive... read more

In-hospital Mortality Associated with the Misdiagnosis or Unidentified Site of Infection at Admission

In-hospital Mortality Associated with the Misdiagnosis or Unidentified Site of Infection at Admission

Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aimed to investigate... read more

Angiotensin II For Septic Shock Treatment

Angiotensin II For Septic Shock Treatment

Angiotensin II has been studied for many years and has consistently shown to increase MAP. This medication adds a new mechanism of action to the vasopressor arsenal that is already used for septic shock. Angiotensin II should... read more

Fluid Responsiveness in Sepsis

Fluid Responsiveness in Sepsis

Fluid challenge is a common practice in the ICU. It is one of the most important resuscitation manoeuvres of acute circulatory failure management in critically ill patients. Adequate fluid resuscitation is very important... read more

Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors

Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors

In this cohort study of 94 748 adult sepsis survivors, age, male sex, 1 or more severe comorbidities, prehospitalization dependency, nonsurgical status, acute severity of illness, site of infection, and organ dysfunction... read more

Machine-learning System Could Aid Critical Decisions in Sepsis Care

Machine-learning System Could Aid Critical Decisions in Sepsis Care

Researchers from MIT and Massachusetts General Hospital (MGH) have developed a predictive model that could guide clinicians in deciding when to give potentially life-saving drugs to patients being treated for sepsis in the... read more

Addressing Shortcomings in Infection and Sepsis Treatment Should Be Top of the Priority List

Addressing Shortcomings in Infection and Sepsis Treatment Should Be Top of the Priority List

Hospitals are increasingly facing the challenge of cutting costs while also improving clinical outcomes. This is certainly true in the infectious disease sector, as unrecognized or ineffectively treated bacterial infections... read more

Mechanical Ventilation Enhances Extrapulmonary Sepsis-induced Lung Injury

Mechanical Ventilation Enhances Extrapulmonary Sepsis-induced Lung Injury

These data show for the first time that otherwise noninjurious mechanical ventilation can exacerbate acute lung injury (ALI) due to extrapulmonary sepsis underscoring a potential interactive contribution of common events... read more

Characteristics, Management, and In-hospital Mortality Among Patients with Severe Sepsis in ICU in Japan

Characteristics, Management, and In-hospital Mortality Among Patients with Severe Sepsis in ICU in Japan

Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this study aimed... read more

Early Sepsis Screening in the Emergency Department

Early Sepsis Screening in the Emergency Department

This single-center retrospective analysis shows promising results with NEWS as a screening tool primarily because it can be done at triage and does not require any laboratory evaluation. This study adds to the current knowledge... read more

Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis

Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis

Combined biomarkers predict risk for 14-day and total mortality among subjects with suspected sepsis. Serum amyloid P and tissue plasminogen activator demonstrated the best discriminatory ability in this cohort. Fourteen-day... read more

A Positive Fluid Balance is an Independent Prognostic Factor in Patients with Sepsis

A Positive Fluid Balance is an Independent Prognostic Factor in Patients with Sepsis

Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has been associated with worse prognosis. We analyzed whether a positive fluid balance and its persistence over... read more

ED Door-to-Antibiotic Time and Long-term Mortality in Sepsis

ED Door-to-Antibiotic Time and Long-term Mortality in Sepsis

Delays in ED antibiotic initiation time are associated with clinically important increases in long-term, risk-adjusted sepsis mortality. This study investigated the association of door-to-antibiotic time with long-term mortality... read more