Tag: sepsis

Is Fever the Normal Temperature of Sepsis

We know that hypothermia in sepsis is associated with increased mortality but other than that we tend to see fever in sepsis as something bad. We tend to perceive sepsis patients as more sick the more the temperature is elevated.... read more

Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock

Targeting higher blood pressure targets may increase mortality in patients who have been treated with vasopressors for more than 6 h. Lower blood pressure targets were not associated with patient‑important adverse events... read more

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Among patients with septic shock undergoing mechanical ventilation, a continuous infusion of hydrocortisone did not result in lower 90-day mortality than placebo. We randomly assigned patients with septic shock who were undergoing... read more

Should We Manage All Septic Patients Based on a Single Definition?

It is indisputable from the biological and clinical perspectives that not all cases of sepsis are the same. On the contrary, most have great many differences, that is, different portals of entry, clinical manifestations,... read more

Hypothermia in Sepsis – The CASS Trial

Sepsis and especially septic shock (no matter what definition you use) is a recipe for multi-organ dysfunction and poor prognosis. In the past few years, we saw a lot of failed attempts trying to find something that could... read more

I survived sepsis eight times. But can care workers spot this deadly illness?

Care staff are increasingly likely to see sepsis, but there is no standard training to make them aware of the symptoms to look out for in clients. There is a golden hour for the treatment of sepsis, when someone can be saved... read more

Acute Kidney Injury in Sepsis

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU and accounts for approximately half of all such... read more

Sepsis Early Warning Score Adopted in UK

Every NHS hospital trust in England will be asked to adopt a new clinical system for assessing acutely ill patients. The National Early Warning Score (NEWS), developed by the Royal College of Physicians (RCP) in 2012, has... read more

Surviving Sepsis

This audio documentary takes a glimpse into the lives of those that have survived the unimaginable.... read more

Initial Crystalloid Resuscitation in Sepsis and Septic Shock

Ludwig Lin, MD, speaks with Daniel E. Leisman, BS, about the article, "Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort," published in Critical... read more

Machine Learning Model Predicts Sepsis in ICU Patients 12 Hours Before Diagnosis

A machine learning model accurately predicted the onset of sepsis in ICU patients four to 12 hours prior to clinical recognition in a recent study. The observational cohort study used data from more than 31,000 admissions... read more

The EM Educator Series: Sepsis in the ED

These posts provide brief mini-cases followed by key questions to consider while working. The featured questions provide important learning points for those working with you, as well as vital items to consider in the evaluation... read more

Chloride and Other Electrolyte Concentrations in Commonly Available 5% Albumin Products

This study is the first to identify and document a statistically significant variability in the chloride concentration of available 5% albumin products. This study has also informed a pilot randomized controlled trial examining... read more

Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization

Over 45% of sepsis patients had clinician-based encounters in the week prior to hospitalization with an increasing frequency of diagnoses for acute infection and antibiotic use in the outpatient setting. These presepsis encounters... read more

Probiotics Offer Powerful Protection Against Sepsis in Infants

Sepsis can occur in just about anyone, including infants. Recent research shows feeding newborns probiotics (healthy bacteria) significantly lowers the child's risk of developing sepsis. The study involved infants in rural... read more

Enhancing Recovery From Sepsis

Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery. In the... read more

Serum Lactate Upon Emergency Department Arrival as Predictor of 30-day In-Hospital Mortality

Despite of numerous evidences that elevated serum lactate levels were associated with unfavorable outcomes, there have been no study demonstrated an optimal cutoff of serum lactate in unselected patients. This study was aimed... read more

Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock

The guideline recommendations showed that shorter delays indicates better outcomes. There was no evidence that 3 hours is safe; even very short delays adversely impact outcomes. Findings demonstrated a new approach to incorporate... read more

A Comparison of the qSOFA and SIRS Criteria for the Diagnosis of Sepsis and Prediction of Mortality

Several studies were published to validate quick-SOFA (qSOFA), namely in comparison with Systemic Inflammatory Response Syndrome (SIRS) criteria. We performed a systematic review and a meta-analysis with the aim of comparing... read more

Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic AKI

In septic acute kidney injury (AKI), renal medullary and urinary hypoxia developed several hours before increases in currently used biomarkers. Angiotensin II transiently improved renal function without worsening medullary... read more

FDA Approves Angiotensin-II for Septic Shock

The FDA approved angiotensin-II (Giapreza) as a new intravenous vasopressor for septic shock and other forms of distributive shock. The first new FDA-approved vasopressor in decades, angiotensin-II could significantly change... read more

The Hidden Faces of Sepsis, What Do They Tell Us?

Based on the patients' perspective Nutma sheds light on the hidden faces of sepsis, calling for more expertise on sepsis sequelae. She also offers recommendations to improve recovery and outcome. Sepsis really caught me by... read more