Plasma Hyaluronan, Hyaluronidase Activity and Endogenous Hyaluronidase Inhibition in Sepsis

Plasma Hyaluronan, Hyaluronidase Activity and Endogenous Hyaluronidase Inhibition in Sepsis

Elevated plasma hyaluronan levels coincided with a concomitant decrease in effective plasma HYAL activity and increase of endogenous plasma HYAL inhibition both in experimental and clinical sepsis. In acute pancreatitis,... read more

Evaluating Vitamin C in Septic Shock

Evaluating Vitamin C in Septic Shock

Vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized. Our findings do not support its routine clinical use for this purpose. Of 124 subjects receiving study drug and included... read more

MIF But Not MIF-2 Recruits Inflammatory Macrophages in an Experimental Polymicrobial Sepsis Model

MIF But Not MIF-2 Recruits Inflammatory Macrophages in an Experimental Polymicrobial Sepsis Model

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF... read more

Quantifying the Burden of Viral Sepsis During the COVID-19 Pandemic and Beyond

Quantifying the Burden of Viral Sepsis During the COVID-19 Pandemic and Beyond

Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide and countless more admissions to hospitals and ICUs. Since... read more

Respiratory Drive in Sepsis and Septic Shock Patients: Modulation by High-flow Nasal Cannula

Respiratory Drive in Sepsis and Septic Shock Patients: Modulation by High-flow Nasal Cannula

Patients with sepsis and septic shock of extrapulmonary origin present elevated respiratory drive and effort, which can be effectively reduced by high-flow nasal cannula. 25 nonintubated patients with extrapulmonary sepsis... read more

Descriptors of Sepsis Using the Sepsis-3 Criteria

Descriptors of Sepsis Using the Sepsis-3 Criteria

We successfully operationalized the Sepsis-3 criteria to an electronic health record dataset to describe the characteristics of critical care patients with sepsis. This may facilitate sepsis research using electronic health... read more

Vasopressor Initiation within 1 Hour of Fluid Loading is Associated with Increased Mortality in Septic Shock Patients

Vasopressor Initiation within 1 Hour of Fluid Loading is Associated with Increased Mortality in Septic Shock Patients

Vasopressor initiation within 1 hour of fluid loading was associated with higher 28-day mortality in patients with septic shock. The median time from the initial fluid bolus to vasopressor was shorter in the early group... read more

Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise

Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise

Intubation within 24 h of sepsis was not associated with hospital mortality but resulted in fewer 28-day hospital-free days. Although intubation remains a high-risk procedure, we did not identify an increased risk in mortality... read more

Predict Sepsis-Associated Vasopressor Use in the ICU

Predict Sepsis-Associated Vasopressor Use in the ICU

Domain adaptation improved performance of a model predicting sepsis-associated vasopressor use during external validation. 40 retrospectively collected features from the electronic medical records of adult ICU patients... read more

Burden of Post-Sepsis Morbidity Higher Than Previously Thought

Burden of Post-Sepsis Morbidity Higher Than Previously Thought

A recent cohort study published in JAMA based on data from 116,507 survivors of hospital-treated sepsis in Germany sheds light on the heavy burden of long-term effects of sepsis, the most severe complication of infections. The... read more

Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis

Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis

We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov... read more

Can Early Cytokine Profile Discriminate Between GPB and GNB?

Can Early Cytokine Profile Discriminate Between GPB and GNB?

Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive... read more

Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections

Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections

Our study identifies a fundamental difference in patient outcomes between first-hit and second-hit bacterial infections, which may be due to genetic, microbiological, immunological, and environmental factors. This finding... read more

Emerging Advances have the Potential to Change the Future of Sepsis Care

Emerging Advances have the Potential to Change the Future of Sepsis Care

In recent years, many advances in the sepsis literature have occurred, including new definitions, changes to the Surviving Sepsis Campaign (SSC) bundles, new pharmacologic agents, and adjunct treatments. There are also... read more