Hospital-Readmission Risk – Isolating Hospital Effects from Patient Effects

When the same patients were admitted with similar diagnoses to hospitals in the best-performing quartile as compared with the worst-performing quartile of hospital readmission performance, there was a significant difference... read more

Hospital-Readmission Risk – Isolating Hospital Effects from Patient Effects

Can Early Rehabilitation on the General Ward After an ICU Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?

An early rehabilitation program in survivors of critical illness led to an earlier discharge from the hospital, improved functional recovery, and was also cost-effective and safe. In the per-protocol analysis, length of... read more

Can Early Rehabilitation on the General Ward After an ICU Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?

Hypertension and Prehypertension Underdiagnosed, Undertreated in U.S. Children

Hypertension and prehypertension in children often go undiagnosed, according to a new study published in Pediatrics. The study focused on children with abnormal blood pressures across the United States.... read more

Hypertension and Prehypertension Underdiagnosed, Undertreated in U.S. Children

The Ability of ICU Physicians to Estimate Long-Term Prognosis in Survivors of Critical Illness

Prognoses estimated by physicians incorrectly predicted long-term survival and HRQoL in one-third of ICU survivors. Moreover, inaccurate prognoses were generally the result of overoptimistic expectations of outcome. Among... read more

The Ability of ICU Physicians to Estimate Long-Term Prognosis in Survivors of Critical Illness

Conscious Sedation in TAVR Linked to Lower Mortality and Shorter Hospital Stays

The study, which captured approximately 90% of all patients who underwent TAVR in the United States during the study period, adds to a limited evidence base on the use of conscious sedation in this setting. Among those treated... read more

Conscious Sedation in TAVR Linked to Lower Mortality and Shorter Hospital Stays

Association Between mRNA Expression of CD74 and IL10 and Risk of ICU-acquired Infections

Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs and mortality. To date, no biomarker has shown sufficient evidence and ease of application in clinical routine for the identification... read more

Association Between mRNA Expression of CD74 and IL10 and Risk of ICU-acquired Infections

Patient Safety Collaborative Impact on Hospital-Acquired Harm

Improving patient safety often involves multifaceted interventions intended to change complex workflows. This prospective cohort study examined whether a collaborative improvement initiative across 33 pediatric hospitals... read more

Patient Safety Collaborative Impact on Hospital-Acquired Harm

The Overlaps of Asthma or COPD with OSA

Asthma, chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are the most common respiratory disorders worldwide. Given demographic and environmental changes, prevalence for each is likely to increase. Some... read more

The Overlaps of Asthma or COPD with OSA

Antibiotic Prescription Fill Rates Declining

Since 2010, antibiotic prescription rates in the U.S. have been declining among the commercially insured population, falling 9 percent during this period. In this report, the Blue Cross Blue Shield Association, in partnership... read more

Antibiotic Prescription Fill Rates Declining

Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium

Delirium was associated with memory impairment and PTSS-14 scores suggestive of PTSD, but not illness severity. 181 subjects were included. Illness severity did not correlate with delirium duration. On logistic regression,... read more

Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium

Biomarkers in AKI: That’s All the Story?

We would like to add to the recent editorial by McMahon on biomarkers of acute kidney injury (AKI), with a specific focus on biomarkers in the clinical setting of cardiac surgery-associated AKI (CSA-AKI). We agree with McMahon... read more

Biomarkers in AKI: That’s All the Story?

Cochrane Strategy to 2020

Strategy to 2020 aims to put Cochrane evidence at the heart of health decision-making all over the world. It defines how we intend to accomplish this and provides a framework for Cochrane's future decision-making, helping... read more

Cochrane Strategy to 2020

Individualizing Thresholds of Cerebral Perfusion Pressure Using Estimated Limits of Autoregulation

Individualized autoregulation-guided cerebral perfusion pressure management may be a plausible alternative to fixed cerebral perfusion pressure threshold management in severe traumatic brain injury patients. Prospective randomized... read more

Individualizing Thresholds of Cerebral Perfusion Pressure Using Estimated Limits of Autoregulation

Oxygen Therapy in Suspected Acute Myocardial Infarction

Routine use of supplemental oxygen in patients with suspected myocardial infarction who did not have hypoxemia was not found to reduce 1-year all-cause mortality. A total of 6629 patients were enrolled. The median duration... read more

Oxygen Therapy in Suspected Acute Myocardial Infarction

Are contact isolation precautions (CP) necessary when caring for patients infected or colonized with endemic MRSA or VRE?

Researchers from the University of Nebraska Medical Center Division of Infectious Diseases and Nebraska Medicine Department of Infection Control and Epidemiology recently published results from a two-year observational study... read more

Are contact isolation precautions (CP) necessary when caring for patients infected or colonized with endemic MRSA or VRE?

Hyperfibrinolysis in Severe Isolated TBI May Occur Without Tissue Hypoperfusion

Hyperfibrinolysis is associated with tissue injury in both patients with traumatic brain injury (TBI) and in non-TBI patients. However, tissue hypoperfusion is associated with hyperfibrinolysis in non-TBI patients, but not... read more

Hyperfibrinolysis in Severe Isolated TBI May Occur Without Tissue Hypoperfusion

Microcirculatory assessment of patients under VA-ECMO

Of the 24 patients included in the study population, 15 survived and 9 died while on VA-ECMO. PVD of the sublingual microcirculation at initiation of VA-ECMO can be used to predict ICU mortality in patients with cardiogenic... read more

Microcirculatory assessment of patients under VA-ECMO

Acetaminophen in the ICU: Mixed Findings

Does having a fever help fight infection? Patients who got acetaminophen to relieve fever while in intensive care units did about as well as patients who got a placebo when it came to mortality. But in a puzzling finding,... read more

Acetaminophen in the ICU: Mixed Findings