Tag: study
Acute Effects of Ketamine on ICP in Children With Severe TBI
In this retrospective, exploratory study, intracranial pressure (ICP) did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during... read more
Baricitinib or Tocilizumab for Severe COVID-19 Treatment
Pharmacologic treatment of COVID-19 has continued to evolve since the onset of the pandemic, and yet many questions remain about optimal treatment. Medicine strives to provide evidence-based guidance on treatments, but... read more
6 Days Higher-Dose Ivermectin vs. Placebo on Time to Sustained Recovery in COVID-19 Outpatients
Among a largely vaccinated outpatient population with mild to moderate COVID-19, treatment with ivermectin, with a targeted maximum dose of 600 μg/kg daily for 6 days, compared with placebo was not shown to improve time... read more
The effect of a multi-faceted quality improvement program on paramedic intubation success in the critical care transport environment
A multi-faceted advanced airway management (AAM) quality improvement program (QIP) resulted in statistically significant increase in intubation first pass success rates (FPS) rates and a non-significant improvement in DASH-1A... read more
Improving Access to ECMO for OHCA
Mobile teams using transport accessibility frameworks and principles can significantly improve patient access for out-of-hospital cardiac arrest (OHCA) compared to in-hospital extracorporeal cardiopulmonary resuscitation... read more
Remote Ischemic Conditioning in Septic Shock
The treatment known as RECO did not significantly reduce the severity of organ failure as measured by the mean daily SOFA (sequential organ failure assessment) score from the start of the study to day 4 in patients with septic... read more
Molnupiravir Improves Recovery Time in COVID-19 Patients at High Risk of Severe Outcomes
This analysis of a large randomized trial involving people who are at high risk of experiencing severe outcomes from COVID-19 and who had been vaccinated against SARS-CoV-2 infection found that adding molnupiravir to usual... read more
Family Presence During Cardiac Arrest Resuscitation
This systematic review identified four key findings. Firstly, there was a lack of high-quality evidence on the impact of family presence during resuscitation on patient outcomes. Secondly, family members had varied... read more
Time from Infiltrate on Chest Radiograph to VV ECMO in COVID-19 Affects Mortality
Venovenous extracorporeal membrane oxygenation (VV ECMO) has been used to treat severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome; however, patient selection criteria have evolved throughout the... read more
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest
Targeting a mean arterial blood pressure of 77 mm Hg or 63 mm Hg in patients who had been resuscitated from cardiac arrest did not result in significantly different percentages of patients dying or having severe disability... read more
Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C
Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true injury or a pseudotoxicity characterized... read more
Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients
Feed intolerance (FI) is common in critically-ill cirrhosis patients and non-resolution carries high mortality. Early recognition and treatment with prokinetics is recommended to improve short-term survival. Of the 1,030... read more
Plasma Exchange in the ICU
In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement... read more
Septic Shock Developing Later During Hospital Stay Associated with Higher Mortality
In-hospital mortality continued to rise as admission-shock-onset-time increased in patients with septic shock. No clear dichotomization between early and late septic shock could be ascertained, and this categorization may... read more
Care Step Pathway an Effective Tool For Clinicians Caring for Mechanical Ventilated COVID-19 Patients
The Care Step Pathway (CSP) described in this article was developed to increase awareness of the potential association of SARS-CoV-2 infection with invasive fungal infections, particularly pulmonary aspergillosis. The... read more
Dexmedetomidine vs. Propofol Sedation in Critically Ill Adults Requiring Mechanical Ventilation
Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and the risk of delirium in cardiac surgical patients. It also significantly... read more
Myocarditis After COVID‐19 mRNA Vaccination in Australia
Myocarditis in adolescents and young adults following the administration of coronavirus disease 2019 (COVID‐19) mRNA vaccines has been reported. Vaccination of 12–16‐year‐old adolescents with Comirnaty (tozinameran,... read more
Improving Outcomes in Patients with Difficult Airways
Evidence indicates that the airway community has successfully conquered the anatomically difficult airway, as these patients are managed safely with a low incidence of morbidity and mortality. In contrast, the literature... read more
