Tag: study
The Association Between Pain, Analgesia, and Delirium in Critically Ill Adults
We observed an association between pain and incident delirium among critically ill adults. Exposure to morphine or fentanyl (but no other pain medications) was associated with increased risk of delirium occurrence. From... read more
Using AI to Detect and Treat Delirium
The prevention of delirium in ICU represents a major unmet need because of its high prevalence, under-diagnosis, and independent association with adverse outcomes including higher mortality and accelerated cognitive decline.... read more
Bundle of Care Effectiveness on Tolerance of Awake-prone Positioning in ARF Patients
In the evaluated population of patients with COVID-19-related ARF, implementing a bundle-of-care strategy was associated with a longer AW-PP exposure and a reduced risk of endotracheal intubation. In this secondary analysis... read more
Major Cardiovascular Surgery-induced Metabolic Reprogramming Role in AKI
Major cardiovascular surgery, particularly with cardiopulmonary bypass (CPB), induces significant changes in protein metabolism. Patients developing postoperative acute kidney injury (AKI) exhibited specific metabolic signatures.... read more
Ventilation Practices in ABI Patients and Association with Outcomes
Current mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association... read more
Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients
The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more
PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections
Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more
Blood Glucose and Clinical Outcomes After ECC
Postoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery. The study's primary outcome was the 90-day mortality,... read more
Helmet CPAP as NIV for COVID-19 Patients
The COVID-19 pandemic has challenged healthcare systems globally, highlighting the need for effective respiratory support strategies. Helmet continuous positive airway pressure (CPAP) has emerged as a potential noninvasive... read more
Tracheostomy in COVID-19 Patients
Tracheostomy is common in critically ill COVID-19 patients. In patients predicted to need a tracheostomy at some point, early, rather than late, tracheostomy might be a means to reduce the time spent in ICU. However,... read more
Pirfenidone to Prevent Fibrosis in ARDS
Pulmonary fibrosis is a major complication of the Acute Respiratory Distress Syndrome (ARDS). Pirfenidone is an approved treatment for idiopathic pulmonary fibrosis. It may attenuate ARDS-related fibrosis and decrease the... read more
Association Between Osteopontin and Apolipoprotein E gene Polymorphisms and Vancomycin-induced AKI
Individuals carrying specific genotypes of APOE (e2e3) were more prone to develop vancomycin-induced acute kidney injury (AKI), per se. This could apply to other nephrotoxic agents as well. We also observed a significant... read more
Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors
The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more
Lactate Trajectory Models for Predicting AKI and Mortality in Hyperlactatemia Patients
The present study underscores the significant prognostic value of lactate trajectories in critically ill patients, particularly those with hyperlactatemia. Our findings suggest that rapid lactate clearance is strongly... read more
Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients
The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more
COVID-19 vs non-COVID-19 Patients Without Hematological Malignancies Treated for Invasive Pulmonary Aspergillosis
COVID-19-associated pulmonary aspergillosis (CAPA) patients have less comorbidities and higher fungal burden compared to Putative Invasive Pulmonary Aspergillosis (PIPA), but clinical outcomes are similar between groups.... read more
Clinical Prediction Model Development for Stages of AKI in Critically Ill Patients
Using readily available predictors in the ICU setting, we could develop a prediction model for different stages of AKI with good performance and promising clinical usefulness. Among critically ill patients, acute kidney... read more
Provocative Angiography Safety and Efficacy for Gastrointestinal Hemorrhage Localization and Treatment
This study demonstrated that provocative angiography was safe and effective for localization of intermittent or occult gastrointestinal bleeding. Overall, provocative angiography had a positivity rate of 14/40 (35 %) in this... read more
Total Bilirubin as a Marker for Hemolysis and Outcome in ARDS Patients Treated with vvECMO
Patients with acute respiratory distress syndrome (ARDS), treatment with veno-venous ECMO and a total bilirubin (tBili) plasma concentration over the threshold of 3.6 mg/dl had significantly lower chances of survival, recovery... read more
COVID-19 Omicron: Immunocompromised vs. Non-immunocompromised Patients
Immunocompromised patients admitted to the ICU due to COVID-19 during the omicron period had higher mortality than non-immunocompromised patients. Additionally, immunocompromised patients with COVID-19 had higher mortality... read more
Airflow Patterns and Adaptive Attachment Ventilation with Deflectors
A novel ventilation mode was introduced and investigated by a series of experiments under isotherm condition, focusing on elucidating the airflow patterns and characteristics associated with this mode. Semi-empirical equations... read more
Failure to Rescue in ALF
The concept of failure to rescue has been used to measure the quality of care for complications developed following surgery. In patients with acute liver failure (ALF), the concept of failure to rescue highlights the... read more
