Tag: study
Mitochondrial Damage-Associated Molecular Patterns Exacerbate Lung Fluid Imbalance Via the Formyl Peptide Receptor-1 Signaling Pathway in Acute Lung Injury
Mitochondrial damage–associated molecular patterns exacerbate lung fluid imbalance in the experimental acute lung injury model through formyl peptide receptor-1 signaling, the inhibition of which may prevent exacerbation... read more
Long-Term Sustainability and Acceptance of Antimicrobial Stewardship in Intensive Care
An antimicrobial stewardship program implemented over a decade resulted in sustained suggestion and acceptance rates. These findings support the need for a persistent presence of audit-and-feedback over time with more frequent... read more
Pulse Oximeter Devices Have Higher Error Rate in Black Patients
A study showed that the devices, which measure oxygen levels in the blood, were three times more likely to give misleading readings among African-American patients. Pulse oximeters are one of the most commonly used tools... read more
It Is a Marathon, Not a Sprint – Sustainability of Stewardship in ICUs
ICUs are arguably the most important yet most challenging hospital environments for antimicrobial stewardship. The stakes are high with critically ill patients, where the burden of resistant Gram-negative pathogens is greater... read more
ICU Delirium-Prediction Models: A Systematic Review
Although most ICU delirium-prediction models have relatively good performance, they have limited applicability to clinical practice. Most models were static, making predictions based on data collected at a single time-point,... read more
Prediction of Neurological Outcomes in Patients Treated With ECPR
This prognostic study develops and validates a prediction model for neurological outcomes of patients with out-of-hospital cardiac arrest with shockable rhythm treated with extracorporeal cardiopulmonary resuscitation. A... read more
Doppler Echocardiographic Indices in Critically Ill Patients Under Mechanical Ventilation
Doppler Echocardiographic Indices Are Specific But Not Sensitive to Predict Pulmonary Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation. The objective of this study was to prospectively... read more
Increasing suction pressure during endotracheal suctioning increases the volume of suctioned secretions
It may be assumed that 250 mmHg suction pressure, via compliance with open system suction method related procedures, is being more effective and equally safe for secretion cleaning in comparison to the 80 and 150 mmHg suction... read more
The Emerging Evidence for a Genetic Susceptibility to Severe COVID-19
A defining feature of the COVID-19 pandemic has been the wide spectrum of clinical presentations, ranging from asymptomatic viremia to life-threatening illness. Factors such as advancing age and co-morbid status have been... read more
Genetic Mechanisms of Critical Illness in COVID-19
Host-mediated lung inflammation is present, and drives mortality, in critical illness caused by COVID-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development. Here... read more
Improved Oxygenation After Prone Positioning May Be a Predictor of Survival in Patients With ARDS
We found a significant difference in the Pao2:Fio2 ratio after the first prone positioning between ICU survivors and nonsurvivors. The improvement in oxygenation after the first prone positioning was a significant predictor... read more
Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis
Dysregulated immune response is a key driver of disease progression in sepsis and known to be associated with impaired cellular metabolism. This association has been studied mostly in the late stage sepsis patients. Here,... read more
Nurses’ knowledge and practices of physical restraints in ICU
The mean scores of nurses' knowledge and practices were 61.5 (SD = 12.1) and 57.4 (SD = 9.7), respectively. More than half of nurses had poor knowledge of PR use and incorrect practice of implementing PR (51.5% and 60.5%,... read more
Endotracheal intubation to reduce aspiration events in acutely comatose patients
Whether intubation results in a reduction in the incidence of aspiration events and whether these are more frequent in patients with low GCS scores are not yet established. The paucity of evidence on this topic makes clinical... read more
Anaesthetists and intensive care doctors are at lower risk of COVID-19 infection compared with other medical staff
Following the first recorded death of an anaesthetist from COVID-19 in the UK in November 2020, a review of available data published in Anaesthesia (a journal of the Association of Anaesthetists) shows that unexpectedly,... read more
Clinical characteristics of critically ill patients with COVID-19
In this study of critical patients infected by SARS-CoV-2 in a high-complexity hospital, the majority were comorbid elderly men, a large percentage required invasive mechanical ventilation, and ICU mortality was 25%. Design... read more
An Online Tool to Simulate the Effect of Pooled Testing for COVID-19
This diagnostic study describes an online tool created with actual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus copy number data to help policy makers understand how pooled testing compares with single-sample... read more
Lung ventilation distribution in patients after traditional full sternotomy and minimally invasive thoracotomy
The aim of the study was to examine the post-operative ventilation distribution changes in cardiac surgical patients after traditional full sternotomy (FS) or minimally invasive thoracotomy (MIT). A total of 40 patients... read more
