Tag: study
Prone Positioning of Nonintubated Patients with COVID-19
Despite the significant variability in frequency and duration of prone positioning and respiratory supports applied, prone positioning was associated with improvement in oxygenation variables without any reported serious... read more
Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Johnson & Johnson Vaccination
The initial 12 US cases of Cerebral Venous Sinus (CVST) with thrombocytopenia after Ad26.COV2.S (Janssen/Johnson & Johnson) vaccination represent serious events. This case series may inform clinical guidance as Ad26.COV2.S... read more
Association Between Pre-Existing Respiratory Disease and COVID-19
Previous studies suggested that the prevalence of chronic respiratory disease in patients hospitalised with COVID-19 was lower than its prevalence in the general population. The aim of this study was to assess whether... read more
Decreased Mortality in ARDS Patients Treated with Corticosteroids
The use of glucocorticoids might result in reduced mortality in patients with ARDS. Glucocorticoids might be recommended as an adjunct to standard care for ARDS; however, the optimal dose and duration of steroid therapy remains... read more
Cerebral Oxygen Saturation and Autoregulation During Hypotension in Extremely Preterm Infants
Dopamine had no effect on rScO2 compared to placebo in hypotensive infants. Hypotension and cerebral hypoxia are associated with early intraventricular hemorrhage or death. Prospective cohort study of blinded rScO2 measurements... read more
Cardiac Markers Implication in Risk-stratification and Management for COVID-19 Patients
COVID-19 patients with pre-existing coronary artery disease represented a higher abnormal percentage of cardiac markers, accompanied by high mortality and ICU admission rate. BNP together with hs-TNI, α- HBDH, CK-MB and... read more
Comparison of the Efficacy and Safety of Cuffed vs. Uncuffed Endotracheal Tubes for Infants in the Intensive Care
There was no difference in the primary outcome, though percentage time spent in optimal leak range was significantly higher in cuffed uncuffed endotracheal tube (ETT) group. Cuffed ETTs reduced reintubations to optimise ETT... read more
Simulated Identification of Silent COVID-19 Infections Among Children
In this simulation modeling study of a synthetic US population, in the absence of vaccine availability for children, a targeted approach to rapidly identify silent COVID-19 infections in this age group was estimated to significantly... read more
Escalation and Withdrawal of Treatment for Patients on ECMO
Discussion between clinicians and families about prognosis and goals was frequent but did not occasion decision-making moments. This study helps explain why communication interventions intended to maintain patient autonomy... read more
Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients
These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute... read more
Clinical Trial of Therapeutics for Severely Ill Hospitalized COVID-19 Patients Begins
A new Phase 3 trial to test the safety and efficacy of therapeutics for COVID-19 has begun enrolling patients hospitalized with life-threatening cases of COVID-19, including those with acute respiratory failure. The trial... read more
A Practical Integrated Radiomics Model Predicting COVID-19 Hospitalization
It has been widely demonstrated that radiological imaging significantly contributes to diagnosing and monitoring pulmonary and systemic involvement of patients affected by COVID-19 using different techniques like chest X-ray... read more
Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults
In this study, low baseline diaphragm muscle mass in critically ill patients was associated with prolonged mechanical ventilation, complications of acute respiratory failure, and an increased risk of death in the hospital. A... read more
Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid
Combinations of coagulation factor concentrates suspended in albumin solutions can restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics... read more
Post‑COVID‑19 Syndrome in Outpatients
Background Some patients experience long-term symptoms after COVID-19, but data on outpatients with mild-to-moderate COVID-19 are scarce. Objective To describe persisting symptoms more than 3 months after infection in PCR-confirmed... read more
10 Scientific Reasons in Support of Airborne SARS-CoV-2 Transmission
Heneghan and colleagues' systematic review, funded by WHO, published in March, 2021, as a preprint, states: "The lack of recoverable viral culture samples of SARS-CoV-2 prevents firm conclusions to be drawn about airborne... read more
Optimal Needle Position for Decompression of Tension Pneumothorax
Tension Pneumothorax (TP) can occur as a potentially life-threatening complication of chest trauma. With the risk of respiratory and cardiac arrest, an immediate temporizing intervention for this condition is required by... read more
90 Day Outcomes of COVID-19 Patients in European ICUs
This communication delineates outcomes in COVID-19 patients in the context of ARDS severity, ventilatory management, and variables associated with mortality on a 90-day follow-up for subgroups of patients after ICU admission.... read more
Effect of Infusion Set Replacement Intervals on Catheter-related Bloodstream Infections
The optimal duration of infusion set use to prevent life-threatening catheter-related bloodstream infection (CRBSI) is unclear. We aimed to compare the effectiveness and costs of 7-day (intervention) versus 4-day (control)... read more
Co-infection in Critically Ill Patients with COVID-19
During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection,... read more
Patient’s Clinical Presentation and CPPopt Availability: Any Association?
In this retrospective multicenter study, none of the selected admission and treatment variables were related to the CPPopt yield. The median CPPopt yield was 80.7% (interquartile range 70.9–87.4%). None of the selected... read more
Mortality Outcomes with Hydroxychloroquine and Chloroquine in COVID-19 Patients
Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate... read more
