Tag: study
Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19
Recent studies have provided insights into the pathogenesis of COVID-19. Yet, longitudinal immunological correlates of disease outcome remain unclear. Here, we serially analysed immune responses in 113 COVID-19 patients with... read more
30% of COVID-19 Patients Had No Symptoms of Fever, Cough, or Shortness of Breath
The findings of this cohort study suggest that screening based on conventional COVID-19 symptoms or corresponding examination findings of febrile respiratory illness may not possess the necessary sensitivity for early diagnostic... read more
Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery
A FF strategy was not associated with changes to early enteral nutrition delivery. Inflammation, insulin resistance, and morbidity were similar, but FF may modify the relationship between inflammation and adverse event. Multicenter... read more
Dexmedetomidine for Prolonged Sedation in the PICU
High-quality data on dexmedetomidine use for prolonged sedation and a consensus on correct dosing and weaning protocols in children are currently missing. Infusion of dexmedetomidine can be considered relatively safe in pediatrics... read more
Preventing Major Airway Complications
Every anaesthetist fears the moment they might become faced with a "can't intubate, can't oxygenate" (CICO) scenario, but thankfully such events are exceedingly rare. They nevertheless receive much attention in the academic... read more
Factors Associated With Death in Critically Ill Patients With COVID-19 in the US
This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies... read more
Early Prediction of ICU-Acquired Weakness
The previously developed prediction model for ICU-AW showed poor performance in a new independent multicenter validation cohort. Model updating methods improved calibration but not discrimination. The newly derived prediction... read more
Research Shows Increased Thrombus Burden in COVID-19 Patients With STEMI
There may be a strong signal towards higher thrombus burden and poorer outcomes in COVID-19 patients presenting with STEMI, supporting the need for establishing COVID-19 status in all STEMI cases, according to a study published... read more
Haloperidol for Treatment of Headache in the ED
Headache is a common chief complaint that emergency physicians encounter almost every day and sometimes multiple times in each shift. In fact, headache is the fifth leading cause of patients presenting to the emergency department... read more
COVID-19: How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies
Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed.... read more
Communication Strategy for Families of Patients Dying in the ICU
Providing relatives of patients who are dying in the ICU with a brochure on bereavement and using a proactive communication strategy that includes longer conferences and more time for family members to talk may lessen the... read more
COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box
Study shows that aerosol box used to protect healthcare workers during COVID intubation increases, rather than decreases, exposure to airborne particles. A new study shows that aerosol boxes that have been manufactured... read more
Harm of IV High-Dose Vitamin C Therapy in Adult Patients
There is no consistent evidence that IV high-dose vitamin C therapy is more harmful than placebo in double-blind randomized controlled trials. However, reports of oxalate nephropathy, hypernatremia, glucometer error, and... read more
Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services
This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... read more
Five COVID-19 Mysteries Scientists Are Still Racing to Solve
Six months and more than ten million confirmed cases later, the COVID-19 pandemic has become the worst public-health crisis in a century. More than 500,000 people have died worldwide. It has also catalysed a research... read more
Autopsies Link Immune Response to Death from COVID-19
An autopsy-based study of 11 people who died from COVID-19 shows a mismatch between viral hotspots in the body and sites of inflammation and organ damage, suggesting that immune responses, rather than the virus itself, are... read more
Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events
Difficult bag-mask ventilation is reported in approximately one in 10 PICU patients undergoing tracheal intubation. Given its association with adverse procedure–related events and oxygen desaturation, future study is warranted... read more
COVID-19 and AKI
Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5,449 hospitalized COVID-19 patients, acute... read more
