Sex Differences in the Outcome of Critically Ill COVID-19 Patients

Among patients admitted to ICU for severe COVID-19, males experienced higher severity of illness and more frequent intervention than females. Ultimately, the hazard of death was moderately elevated in males compared to females... read more

Veno-Arterial-Venous ECMO in a Patient Undergoing Dialysis and Having Cardiopulmonary Failure Due to COVID-19

COVID-19 can cause cardiomyopathy, a rare cardiovascular disorder that can lead to cardiogenic shock. The cardiac and respiratory symptoms may not occur simultaneously, and it is possible to switch to veno-arterial-venous... read more

Adiposity and Mortality Among ICU Patients with COVID-19 and Non-COVID-19 Respiratory Conditions

Obesity is associated with higher mortality among COVID-19 patients, but lower mortality among non-COVID-19 respiratory patients. These associations appear vulnerable to confounding/selection bias in both patient groups,... read more

Outcomes of ECMO in ARDS in Pediatric Trauma Patients

Among children who suffer from acute respiratory distress syndrome (ARDS) complications following trauma, the use of extracorporeal membrane oxygenation (ECMO) failed to show any association with mortality benefit. More... read more

Long-term Effects of Flexible Visitation in the ICU on Patients’ Mental Health

Flexible ICU visitation, compared to the restrictive visitation, was associated with a significant reduction in the 1-year prevalence of post-traumatic stress symptoms in family members. A total of 519 family members were... read more

ICU Cardiac Arrest Among Very Elderly Critically Ill Patients

The occurrence of ICU-CA in critically ill patients with advanced age (≥ 90 years) is relatively rare. The observed mortality in the ICU and hospital was exceedingly high. Notably, providing cardiopulmonary resuscitation... read more

Evidence-Based Critical Care: A Case Study Approach

This book provides learners with a unique opportunity by virtue of the format outlined above. Each case presentation has a case vignette, which leads up to an important clinical question, and is followed by additional discussion... read more

Evidence-Based Critical Care: A Case Study Approach

Corticosteroid Treatment and Survival in Critically Ill COVID-19 Patients

Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid... read more

Long-term Outcomes in Nutrition Trials

Survivors of critical illness frequently suffer from physical, cognitive and mental disorders after hospital discharge, leading to increased disabilities, poor quality of life, and worse long-term outcomes. Therefore,... read more

Predictive Biomarkers of Mortality in ICU Patients with Severe COVID-19

This study shows changes in hematological, biochemical, and inflammatory parameters in COVID-19 non-surviving patients. Lymphopenia, neutrophilia, and thrombocytopenia, as well as increased levels of CRP, AST, creatinine,... read more

Nitric Oxide Inhibitors Changes and Mortality in Critically Ill Patients

Increasing asymmetric dimethylarginine (ADMA) concentrations on days 1-3 are inversely associated with mortality, however not with the same strength as high ADMA or SDMA concentrations at admission. We suggest that admission... read more

Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS

The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more

Hematological, Inflammatory and Serological Responses Among COVID-19 ICU Patients

A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission. Significant... read more

Troponin Role in the Diagnosis and Treatment of Acute Pulmonary Embolism

Acute pulmonary embolism (APE) is a cardiovascular disease with severe consequences, wherein cardiac troponin (Tn) plays a pivotal role in diagnosis and treatment. This article reviews the various roles of Tn in managing... read more

Early Invasive Strategy Impact on Left Ventricular Function Recovery in Acute Myocardial Infarction Patients

This study underscores the significant benefits of early invasive strategies in improving left ventricular function recovery and reducing adverse outcomes in acute myocardial infarction patients in Pakistan. The findings... read more

Non-invasive vs. Arterial Pressure Monitoring in the Pre-hospital Critical Care Environment

Non-invasive blood pressure measurements are often inaccurate within the pre-hospital critical care setting, particularly in patients with hemodynamic instability which are the group in which the accuracy of vital signs is... read more

Antithrombin III Levels and Outcomes Among Patients With Trauma

In this cohort study of trauma patients, antithrombin III deficiency was associated with greater severity of illness and worse hospital outcomes. Specifically, antithrombin III deficiency was associated with fewer ventilator-free... read more