Tag: study
No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children
Aminophylline administration provided a measure of increased diuresis, regardless of dosage, and theophylline trough levels. Therefore, achieving a prescribed therapeutic trough level may not be necessary for full diuretic... read more
Diagnosis and Treatment of Clostridium difficile Infection
Clostridium difficile infection (CDI) is less common than antibiotic-associated diarrhea and irritable bowel syndrome. There is significant concern about overdiagnosis and subsequent overtreatment of CDI with increasing use... read more
SOS Asynchronies: Do We Need Help?
Synchrony between the patient and the ventilator is defined as the appropriate interaction between the two, where the ventilator recognizes patient’s effort and provides support for breathing at the right time—that is,... read more
Gender Disparities Among Adult Recipients of Bystander CPR in the Public
Males had an increased likelihood of receiving Bystander Cardiopulmonary Resuscitation (BCPR) compared with females in public. BCPR improved survival to discharge, with greater survival among males compared with females.... read more
Wage Gap Between Hospital Executives and Doctors is Widening
Over the past decade, salaries for hospital CEOs have risen much faster than for surgeons, physicians, and nurses, reports a study in Clinical Orthopaedics and Related Research. Using publicly accessible data, the researchers... read more
3 Notable Leaps in Sepsis Care
Sepsis is deadly, it's expensive, and there are abundant initiatives underway that could lead to earlier detection, lowering costs, and saving lives. In May 2016, the Healthcare Cost and Utilization Project and the Agency... read more
Chest Radiography vs. Lung Ultrasound for Identification of ARDS
For the identification of acute respiratory distress syndrome (ARDS) using the Berlin definition, both chest radiography and lung ultrasound were equally related to mortality. The Berlin definition using lung ultrasound helped... read more
Watchdog Group Calls for NIH to Halt Dangerous Study of Sepsis Treatment
A medical watchdog group is calling on the National Institutes of Health to immediately stop the enrollment of patients in a clinical trial of sepsis treatment and launch an investigation of how the study received approval,... read more
Comparison of Complication Rates of Central Venous Catheters Versus Peripherally Inserted Central Venous Catheters in Pediatric Patients
Rates of central line–associated bloodstream infection and venous thromboembolism were higher in hospitalized pediatric patients with peripherally inserted central catheters as compared to central venous catheters. Our... read more
Predicting AKI using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac ICUs
Urinary L-FABP and serum NT-proBNP levels on admission are independent predictors of acute kidney injury (AKI), and when used in combination, improve early prediction of AKI in patients hospitalized at medical cardiac intensive... read more
Value of variation index of inferior vena cava diameter in predicting fluid responsiveness in patients with circulatory shock receiving mechanical ventilation
The findings of this study suggest that the ΔIVCD performed moderately well in predicting fluid responsiveness in patients with circulatory shock receiving mechanical ventilation. Overall, 603 patients were included in this... read more
Probiotic and Synbiotic Therapy in the Critically Ill
Recent medical history has largely viewed our bacterial symbionts as pathogens to be eradicated rather than essential partners in optimal health. However, one of the most exciting scientific advances in recent years has been... read more
Direct Discharge From ICU OK for Some Patients
Discharging patients home directly from the intensive care unit (ICU) is associated with outcomes similar to those seen in patients discharged after a follow-up stay on a hospital ward, the authors of a large, population-based... read more
Perspectives on Strained ICU Capacity: A Survey of Critical Care Professionals
Strained intensive care unit (ICU) capacity represents a supply-demand mismatch in ICU care. Limited data have explored health care worker (HCW) perceptions of strain. Strained capacity is perceived as common among inter-professional... read more
Determination of the Feasibility of a Multicomponent Intervention Program to Prevent Delirium in the ICU
During this study a feasible multicomponent intervention program to prevent ICU delirium was developed based on expert consensus. As no consensus was reached on cognitive training, a pilot study is planned to determine the... read more
Achieving Fluid Balance
Kyle Enfield, MD, speaks with Colin K. Grissom, MD, FCCM, and Matthew W. Semler, MD, about fluid management in the critically ill. Dr. Grissom presented his talk, entitled "Achieving Fluid Balance," at the 47th Critical Care... read more
Natural History of COPD Exacerbations in a General Practice-based Population with COPD
A large proportion of patients with chronic obstructive pulmonary disease (COPD) do not exacerbate over a maximum 10 years of follow-up. AECOPD frequency in a single year predicts long-term AECOPD rate. Increasing frequency... read more
The Cumulative Effect of Reporting and Citation Biases on the Apparent Efficacy of Treatments: The Case of Depression
The problem of study publication bias is well-known. Our examination of antidepressant trials, however, shows the pernicious cumulative effect of additional reporting and citation biases, which together eliminated most negative... read more
Hemodynamic Tolerance to IV Clonidine Infusion in the PICU
Although administration of clonidine is often associated with bradycardia and hypotension, these complications do not seem clinically significant in a mixed PICU population with a high degree of disease severity. Clonidine... read more
Integration of Lung Ultrasound in the Diagnostic Reasoning in Acute Dyspneic Patients
Seventy-six physicians responded to the study cases (228 clinical cases resolved). Among the respondents, 28 (37%) were female, 64 (84%) were EPs, and the mean age was 37±8 years. The mean NUDs, respectively, when physicians... read more
Coronary Endothelial Function and Spontaneous Coronary Artery Dissection
Coronary epicardial and microvascular vasomotor dysfunction is not a predominant feature of spontaneous coronary artery dissection. Endothelial dysfunction is not implicated as the principal underlying mechanism. A total... read more
