Tag: study
Prior Exposure to ACEi Increased Cardiovascular Response to Angiotensin-II
Prior exposure to RAS-inhibiting medications was associated with an altered RAS profile and cardiovascular response to angiotensin-II treatment in patients with catecholamine-refractory vasodilatory shock. ACE-inhibitor... read more
Vasopressor Reduction Effect of Polymyxin B Hemoperfusion
This study aimed to evaluate the effect of polymyxin B hemoperfusion (PMX-HP) in patients with peritonitis-induced septic shock who still required high dose vasopressors after surgical source control. A total of 338 patients... read more
Methylene Blue in Sepsis and Septic Shock
This systematic review and meta-analysis evaluated the effect of MB in three RCTs. They found that MB treatment significantly reduced time to vasopressor discontinuation, days on mechanical ventilation, and length of ICU... read more
Cardiac Index and Heart Rate as Prognostic Indicators for Mortality in Septic Shock
Our retrospective study shows that monitoring cardiac index and heart rate in patients with septic shock may help predict the organismal response and hemodynamic consequences, as well as the prognosis. Thus, healthcare providers... read more
Fluid Personalization and Vasopressor Decisions in Early Sepsis Management
In this randomized vignette survey study of US critical care clinicians, we found that fluid volume already received was associated with the largest changes in decisions to administer additional fluids or initiate vasopressors... read more
AKI Risk Factors in ICU Patients Using Colistin
Colistin, an antibiotic of polymyxin group, has recently been increasingly used in the treatment of multidrug resistant gram-negative bacteria. However, it has serious adverse effects such as acute kidney injury (AKI). We... read more
Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU
We analyzed unvaccinated critically ill ICU patients with COVID-19 and interpreted their demographics, clinical characteristics, comorbidities, and laboratory data upon ICU admission for a better understanding of their impact... read more
Haloperidol vs. Placebo in ICU Patients with Delirium
We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. In acutely admitted adult ICU patients with delirium, haloperidol treatment... read more
Critical Hypertension in Trauma Patients Following Prehospital Emergency Anesthesia
Delivery of prehospital emergency anesthesia (PHEA) to seriously injured trauma patients risks hemodynamic fluctuation. In adult trauma patients undergoing PHEA, 11.9% of patients experienced post-PHEA critical hypertension.... read more
Ilofotase Alfa Doesn’t Improved Survival Among Critically Ill Patients with SA-AKI
Sepsis-associated acute kidney injury (SA-AKI) in patients admitted to an intensive care unit is associated with significant morbidity and mortality. There is currently no pharmaceutical treatment. Although we found no... read more
Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Patients with AHRF
This study suggests that high-flow nasal cannula (HFNC) therapy in general respiratory wards may be a potential rescue therapy for patients with respiratory failure. Electrical impedance tomography (EIT) potentially monitors... read more
Intravenous Vitamin C for COVID-19 Patients
In hospitalized patients with COVID-19, vitamin C had low probability of improving the primary composite outcome of organ support–free days and hospital survival. Enrollment was terminated after statistical triggers... read more
Oxygenation Improvement in Hyperinflammatory Ovine ARDS Treated with Methylprednisolone
Early and persistent improvement in oxygenation was seen only in hyperinflammatory ovine ARDS treated with methylprednisolone, while hemodynamic situation and survival was improved in both injury models and corticosteroid... read more
Uncovering Heterogeneity in Sepsis
Among critically ill patients with sepsis, subtype strategies using clinical, biomarker, and transcriptomic data do not identify comparable patient populations and are likely to reflect disparate clinical characteristics... read more
Pediatric Sepsis Phenotype with Persistent Hypoxemia, Encephalopathy, and Shock
We derived and validated the persistent hypoxemia, encephalopathy, and shock phenotype, which is highly reproducible, clinically relevant, and associated with HTE to common adjuvant therapies in children with sepsis. We... read more
Genetic Causal Factors of ARDS
This comprehensive study highlights the importance of utilizing the MR-pheWAS framework in unraveling the complex etiology and pathogenesis of ARDS, and further underlines the value of integrating blood-based biomarkers into... read more
A Global Perspective on AKI After Major Surgery
Acute kidney injury (AKI) is an abrupt decline in kidney function occurring within hours or days. In patients having surgery, postoperative AKI is a major complication associated with adverse outcomes including mortality.... read more
COVID-19 Severity and 2-year Prevalence of Physical Symptoms
Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence... read more
