Tag: study
Association Between Osteopontin and Apolipoprotein E gene Polymorphisms and Vancomycin-induced AKI
Individuals carrying specific genotypes of APOE (e2e3) were more prone to develop vancomycin-induced acute kidney injury (AKI), per se. This could apply to other nephrotoxic agents as well. We also observed a significant... read more
Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors
The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more
Lactate Trajectory Models for Predicting AKI and Mortality in Hyperlactatemia Patients
The present study underscores the significant prognostic value of lactate trajectories in critically ill patients, particularly those with hyperlactatemia. Our findings suggest that rapid lactate clearance is strongly... read more
Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients
The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more
COVID-19 vs non-COVID-19 Patients Without Hematological Malignancies Treated for Invasive Pulmonary Aspergillosis
COVID-19-associated pulmonary aspergillosis (CAPA) patients have less comorbidities and higher fungal burden compared to Putative Invasive Pulmonary Aspergillosis (PIPA), but clinical outcomes are similar between groups.... read more
Clinical Prediction Model Development for Stages of AKI in Critically Ill Patients
Using readily available predictors in the ICU setting, we could develop a prediction model for different stages of AKI with good performance and promising clinical usefulness. Among critically ill patients, acute kidney... read more
Provocative Angiography Safety and Efficacy for Gastrointestinal Hemorrhage Localization and Treatment
This study demonstrated that provocative angiography was safe and effective for localization of intermittent or occult gastrointestinal bleeding. Overall, provocative angiography had a positivity rate of 14/40 (35 %) in this... read more
Total Bilirubin as a Marker for Hemolysis and Outcome in ARDS Patients Treated with vvECMO
Patients with acute respiratory distress syndrome (ARDS), treatment with veno-venous ECMO and a total bilirubin (tBili) plasma concentration over the threshold of 3.6 mg/dl had significantly lower chances of survival, recovery... read more
COVID-19 Omicron: Immunocompromised vs. Non-immunocompromised Patients
Immunocompromised patients admitted to the ICU due to COVID-19 during the omicron period had higher mortality than non-immunocompromised patients. Additionally, immunocompromised patients with COVID-19 had higher mortality... read more
Airflow Patterns and Adaptive Attachment Ventilation with Deflectors
A novel ventilation mode was introduced and investigated by a series of experiments under isotherm condition, focusing on elucidating the airflow patterns and characteristics associated with this mode. Semi-empirical equations... read more
Failure to Rescue in ALF
The concept of failure to rescue has been used to measure the quality of care for complications developed following surgery. In patients with acute liver failure (ALF), the concept of failure to rescue highlights the... read more
Oral Health Care and VAP in ICU Patients
Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more
Nebulized Long-Acting Bronchodilators to Treat ARF in an Older Patients
Although long-acting bronchodilators are not approved to treat acute respiratory failure (ARF), the older adult in this case clinically improved after three doses of revefenacin and arformoterol. Additional studies are... read more
Different Anticoagulation Regimens Effectiveness in Critically Ill Patients
This study compared the efficacy of therapeutic anticoagulation guided by anti-Xa levels vs. a D-dimer-based protocol in ICU patients with COVID-19. Given the heightened risk of thrombosis despite anticoagulation therapy... read more
Methylprednisolone vs. Hydrocortisone in Septic Shock Patients
Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more
Elevated BCR Risk Factor For CHF in Critically Ill COPD Patients
Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and death. The blood urea nitrogen-to-creatinine ratio (BCR) is recognized as a crucial marker to assess renal function and cardiovascular... read more
Assessing the Risk of Poor Clinical Outcomes in Preterm Neonates with Late-onset Sepsis
A predictive calculator for assessing the risk of poor clinical outcomes in preterm neonates with late-onset sepsis (LOS) has been developed. By leveraging readily available clinical data at the time of blood culture collection,... read more
Patients Under Mechanical Ventilation Are Highly Perceptive
This meta-synthesis provides insights into the perception of intensive care patients under Mechanical Ventilation (MV) who are continuously observing their own lives. This process is complex and involves a highly differentiated... read more
Hemoglobin Glycation Index vs. Adverse Outcomes in Critically Ill Patients with Myocardial Infarction
Based on the MIMIC-IV database, this study found that lower HGI is significantly associated with an increased risk of short-, mid- and long-term all-cause mortality in critically ill myocardial infarction (MI) patients. As... read more
Predicting SA-AKI Mortality Using XGBoost Algorithm
The integration of advanced techniques with the XGBoost algorithm yielded a highly accurate and interpretable model for predicting Sepsis-Associated Acute Kidney Injury (SA-AKI) mortality across diverse populations. It... read more
Pharmacokinetics of Opioid Infusions in the Adult ICU Setting
To counter these pharmacokinetics (PKs) alterations, new therapeutic avenues must be further explored in the ICU to individualize opioid infusions. Embase, MEDLINE, PubMed, CINAHL, and Evidence-Based Medicine Reviews (EBMR)... read more
Clinical Efficacy of Nafamostat Mesylate-assisted CRRT Therapy in SA-AKI Patients
Nafamostat Mesylate (NM)-assisted continuous renal replacement therapy (CRRT) therapy significantly improves the therapeutic efficacy of patients with sepsis-associated acute kidney injury (SA-AKI). This combined approach... read more
