Tag: study
PAH Associated With Systemic Lupus Erythematosus
Patients with SLE-PAH have an overall 5-year survival rate of 83.9% after the Pulmonary Arterial Hypertension (PAH) diagnosis. Anti-SSA/SSB antibodies may be a risk factor for PAH, and the presence of anti-U1-RNP antibodies... read more
A Measure of Physicians’ Motivation to Adopt Medical Devices
This is the first reliable and valid scale to measure physicians' adoption motivation. Future adoption studies assessing the individual level should include the PMA scale to obtain more information about the role of physicians’... read more
Assessing Usefulness of Randomized Clinical Trials
In the pyramid of evidence based medicine randomized controlled trials (RCTs) are considered to be one of the most reliable study designs when evaluating the cause and effect of treatment modalities. When evaluating randomized... read more
Furosemide in the Treatment of Acute Pulmonary Edema
CHF is a common problem in the US with over 5 million patients carrying the diagnosis and 500,000 new diagnoses each year.1 Cardiogenic acute pulmonary edema (APE) occurs when blood backs up into the pulmonary vasculature... read more
Core Outcome Measures for Clinical Research in ARF Survivors
This Core Outcome Measurement Set is recommended for use in all clinical research evaluating acute respiratory failure (ARF) survivors after hospital discharge. In the future, researchers should evaluate measures for outcomes... read more
New-Onset Atrial Fibrillation in the Critically Ill
Kyle Enfield, MD, speaks with Travis J. Moss, MD, MSc, and J. Randall Moorman, MD, about the article, "New-Onset Atrial Fibrillation in the Critically Ill," published in the May 2017 issue of Critical Care Medicine. Drs.... read more
Higher PEEP versus Lower PEEP Strategies for Patients with ARDS
Use of higher positive end-expiratory pressure (PEEP) is unlikely to improve clinical outcomes among unselected patients with ARDS. We identified eight randomized trials comparing higher versus lower PEEP strategies, enrolling... read more
Is this critically ill patient elderly or too old?
Life expectancy is increasing in industrialized countries. It is forecast that in the European Union 24.4 million people will be older than 85 years in 2040, more than doubling from the 10.4 million seen in 2010. In parallel,... read more
Understanding Adrenal Crisis
Approximately 5–17 cases of adrenal crisis (AC) occur per 100 patient years in patients with primary or secondary adrenal insufficiency (AI). The mortality rate is estimated to be between 0.5% and 2%. Norwegian data indicate... read more
Alarm Fatigue in ICU Addressed in Two Studies
Alarm fatigue within the intensive care unit (ICU) can negatively impact patient safety and lead to life-threatening events. Researchers from Harlem Hospital and Maimonides Medical Center aimed to identify solutions fight... read more
Bedside Chest Radiographs in the ICU – DRw vs. CR
Critical care chest radiography with a portable wireless direct radiography (DRw) system can provide similar or superior information compared to a computed radiography (CR) system regarding clinically significant findings... read more
Translational Evidence for Two Distinct Patterns of Neuroaxonal Injury in Sepsis
Ischemic and diffuse neuroaxonal injury to the brain in experimental sepsis, human postmortem brains, and in vivo MRI suggest these two distinct lesion types to be relevant. Future studies should be focused on body fluid... read more
Barriers to Delirium Assessment in the ICU
Many barriers exist to prevent effective assessment and management of delirium, but several of these are due to a lack of understanding or unfamiliarity with the condition and the assessment tools as well as lack of medical... read more
Oral Antibiotics Preferred for Pediatric Pneumonia
Children with complicated pneumonia should be discharged from the hospital with oral instead of intravenous (IV) antibiotics when possible, according to a new study. The results showed no significant differences in treatment... read more
Aerosol Delivery During Invasive Mechanical Ventilation
Lung deposition was lower than 20% of nominal dose delivered with nebulizers and mostly occurred in proximal airways. Further studies are needed to link substantial concentrations of antibiotics in infected pulmonary fluids... read more
Can this patient be safely weaned from RRT?
The timing of initiation of renal replacement therapy (RRT) in the critically ill with acute kidney injury (AKI) has been widely studied and discussed in detail recently. However, there is limited information and few recommendations... read more
Active Noise Control Headphones to Reduce Patient’s Exposure to ICU Noise
The use of active noise cancellation, as delivered by noise-cancelling headphones, is associated with a significant reduction in noise exposure in our model of noise exposure in a cardiac ICU. This is the first study to look... read more
Opioid use to worse outcomes in C. difficile
A study presented at the World Congress of Gastroenterology found that patients being prescribed opioids who also have Clostridium difficile infections (CDIs) have higher peak white blood cell counts, higher creatinine elevations,... read more
Early Oseltamivir Therapy Improves the Outcome in Critically Ill with Influenza
This real-life study emphasizes oseltamivir efficacy on in-hospital outcome when administrated within 2 days of the onset of symptoms. Even if physicians' awareness of the influenza disease has been undeniably enhanced... read more
Humanizing the Treatment of Hyperactive Delirium in the Last Days of Life
When patients with advanced cancer near the end of their life, it is important for physicians, nurses, and other health care personnel to respect and dignify the dying process of the patient. This requires a shift in focus... read more
Sound and Light Levels Are Similarly Disruptive in ICU and non-ICU Wards
Quieter, non-ICU wards have as many SLCs as ICUs do, which has implications for quality improvement measurements. Efforts to further reduce average noise levels might be counterproductive. Light levels in the hospital (ICU... read more
2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis
Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on... read more
