Time-limited Trial of Intensive Care Treatment

Time-limited Trial of Intensive Care Treatment

In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition,... read more

Commencing out of bed rehabilitation in critical care – what influences clinical decision-making?

Commencing out of bed rehabilitation in critical care – what influences clinical decision-making?

These results confirm previous observational reports that the presence of an endotracheal tube (ETT) remains a major obstacle to the provision of rehabilitation for critically ill patients. Despite rehabilitation being effective... read more

Epidemiology and Changes in Mortality of Sepsis After the Implementation of Surviving Sepsis Campaign Guidelines

Epidemiology and Changes in Mortality of Sepsis After the Implementation of Surviving Sepsis Campaign Guidelines

This is a prospective, multicenter, observational study performed during a 5-month period in 2011 in a network of 11 intensive care units (ICUs). We compared our findings with those obtained in the same ICUs in a study conducted... read more

Effect of Early vs Delayed Initiation of RRT on Mortality in Critically Ill Patients With AKI

Effect of Early vs Delayed Initiation of RRT on Mortality in Critically Ill Patients With AKI

Among critically ill patients with Acute Kidney Injury (AKI), early Renal Replacement Therapy (RRT) compared with delayed initiation of RRT reduced mortality over the first 90 days. Further multicenter trials of this intervention... read more

Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Haemoglobin concentration decreases during resuscitation from septic shock, and has a significant but weak association with the volume of intravenous fluids administered. Median (IQR) haemoglobin concentration at baseline... read more

No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children

No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children

Aminophylline administration provided a measure of increased diuresis, regardless of dosage, and theophylline trough levels. Therefore, achieving a prescribed therapeutic trough level may not be necessary for full diuretic... read more

Diagnosis and Treatment of Clostridium difficile Infection

Diagnosis and Treatment of Clostridium difficile Infection

Clostridium difficile infection (CDI) is less common than antibiotic-associated diarrhea and irritable bowel syndrome. There is significant concern about overdiagnosis and subsequent overtreatment of CDI with increasing use... read more

SOS Asynchronies: Do We Need Help?

SOS Asynchronies: Do We Need Help?

Synchrony between the patient and the ventilator is defined as the appropriate interaction between the two, where the ventilator recognizes patient’s effort and provides support for breathing at the right time—that is,... read more

Gender Disparities Among Adult Recipients of Bystander CPR in the Public

Gender Disparities Among Adult Recipients of Bystander CPR in the Public

Males had an increased likelihood of receiving Bystander Cardiopulmonary Resuscitation (BCPR) compared with females in public. BCPR improved survival to discharge, with greater survival among males compared with females.... read more

Wage Gap Between Hospital Executives and Doctors is Widening

Over the past decade, salaries for hospital CEOs have risen much faster than for surgeons, physicians, and nurses, reports a study in Clinical Orthopaedics and Related Research. Using publicly accessible data, the researchers... read more

3 Notable Leaps in Sepsis Care

3 Notable Leaps in Sepsis Care

Sepsis is deadly, it's expensive, and there are abundant initiatives underway that could lead to earlier detection, lowering costs, and saving lives. In May 2016, the Healthcare Cost and Utilization Project and the Agency... read more

AIRWAYS-2

AIRWAYS-2

AIRWAYS-2 looks at the initial advanced airway management strategy for paramedics attending out of hospital cardiac arrests, essentially whether or not the aim should be to place a supraglottic airway device or an endotracheal... read more

Chest Radiography vs. Lung Ultrasound for Identification of ARDS

Chest Radiography vs. Lung Ultrasound for Identification of ARDS

For the identification of acute respiratory distress syndrome (ARDS) using the Berlin definition, both chest radiography and lung ultrasound were equally related to mortality. The Berlin definition using lung ultrasound helped... read more

Watchdog Group Calls for NIH to Halt Dangerous Study of Sepsis Treatment

A medical watchdog group is calling on the National Institutes of Health to immediately stop the enrollment of patients in a clinical trial of sepsis treatment and launch an investigation of how the study received approval,... read more