Withdraw Life-Sustaining Treatments for Patients with Severe TBI

The decision to withdraw life support from patients with severe brain injuries is very difficult. In a study conducted in Canadian Medical Association Journal, critical care physicians were asked about the decision-making... read more

Low-value Clinical Practices in Acute Injury Care

This study fills a major knowledge gap on medical procedure overuse in acute injury care. Results will inform research priorities and the development of metrics to measure overuse. This knowledge will provide a solid basis... read more

Low-value Clinical Practices in Acute Injury Care

ICU Patients May Understand Verbal Commands After Acute Brain Injury

A New England Journal of Medicine study shows 1 in 6 clinically unresponsive ICU patients show electroencephalography (EEG) patterns of brain activity when spoken to soon after acute brain injury. A dissociation between the... read more

ICU Patients May Understand Verbal Commands After Acute Brain Injury

Essentials of Neuroanesthesia and Neurointensive Care

This updated second edition of Gupta and Gelb's Essentials of Neuroanesthesia and Neurointensive Care contains the ideal combination of updated information for the practitioner, presented in easy-to-digest short chapters.... read more

Essentials of Neuroanesthesia and Neurointensive Care

Pharmacotherapy in Neurointensive Care

Neurointensive care medicine has experienced great advancements and developments of neuromonitoring techniques, allowing a better comprehension of acute brain injury early phase pathological mechanisms and an overall improvement... read more

Pharmacotherapy in Neurointensive Care

Manual of Traumatic Brain Injury: Assessment and Management

Now completely revised and updated, Manual of Traumatic Brain Injury: Assessment and Management, Second Edition is a comprehensive evidence-based guide to brain injury diagnosis, treatment, and recovery, delivered in a succinct... read more

Manual of Traumatic Brain Injury: Assessment and Management

What influences critical care doctors in withdrawing life support for patients with brain injury?

Decisions to withdraw life support treatments in critically ill patients with severe brain injury are complicated, are based on many factors, and are usually made by critical care physicians and families in the intensive... read more

Sedation in the ICU – Good Past – Better Future?

The concepts for good sedation include defining the range of sedation, the need for agents with rapid response that can be easily and rapidly varied in restless and confused patients, various modes of ventilation, continuous... read more

Sedation in the ICU – Good Past – Better Future?

Determination of Brain Death Under Extracorporeal Life Support

The worldwide use of extracorporeal lung/life support is increasing in severe lung failure (veno-venous extracorporeal membrane oxygenation, vvECMO) or in cardiac arrest/severe circulatory failure (veno-arterial ECMO, vaECMO).... read more

Determination of Brain Death Under Extracorporeal Life Support

Management of Pediatric Severe Traumatic Brain Injury

This article provides an algorithm of clinical practice for the bedside practitioner based on the available evidence, treatment protocols described in the articles included in the 2019 guidelines, and consensus that reflects... read more

Management of Pediatric Severe Traumatic Brain Injury

Intrathoracic Pressure Regulation Therapy Applied to Ventilated Patients for Treatment of Compromised Cerebral Perfusion from Brain Injury

These data support the notion that active intrathoracic pressure regulation, in this limited evaluation, can successfully augment cerebral perfusion by lowering intracranial pressure and increasing mean arterial pressure... read more

Intrathoracic Pressure Regulation Therapy Applied to Ventilated Patients for Treatment of Compromised Cerebral Perfusion from Brain Injury

Tranexamic Acid For Isolated Penetrating Head Trauma

An aeromedical crew was dispatched to a local emergency department to transport a fourteen year-old female with self-inflicted gunshot wound to the head to a tertiary pediatric trauma hospital. The patient was previously... read more

Tranexamic Acid For Isolated Penetrating Head Trauma

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury

Update of the Brain Trauma Foundation Guidelines, Third Edition. Severe Traumatic Brain Injury in Infants, Children, and Adolescents in 2019: Some Overdue Progress, Many Remaining Questions, and Exciting Ongoing Work in the... read more

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury

ECMO in the Critical Trauma Patient

Growing evidence suggests the potential use of Extracorporeal membrane oxygenation (ECMO) for the treatment of refractory respiratory failure in adults, but the clinical benefit in polytraumatic patients is not clear. The... read more

ECMO in the Critical Trauma Patient

The utility of biomarkers in traumatic brain injury clinical management

Currently, TBI management is guided by clinical histories and neuroimaging techniques. While these techniques may be advanced, they are more costly than serum analysis, involve exposure to ionizing radiations, and have certain... read more

The utility of biomarkers in traumatic brain injury clinical management

Meaning of Intracranial Pressure-to-Blood Pressure Fisher-Transformed Pearson Correlation-Derived Optimal Cerebral Perfusion Pressure

These mechanistic simulations provide insight into the empiric basis of optimal cerebral perfusion pressure and the significance of PRx and Δ CPP. PRx and optimal cerebral perfusion pressure deviations do not directly reflect... read more

Meaning of Intracranial Pressure-to-Blood Pressure Fisher-Transformed Pearson Correlation-Derived Optimal Cerebral Perfusion Pressure

Blood test may obviate need for head CTs in brain trauma evaluation

A biomarker test based on the presence of two proteins in the blood appears to be suitable for ruling out significant intracranial injuries in patients with a history of mild traumatic brain injury (TBI) without the need... read more

Blood test may obviate need for head CTs in brain trauma evaluation

Presenting Characteristics Associated With Outcome in Children With Severe TBI

Severe traumatic brain injury is a clinically heterogeneous disease that can be accompanied by a range of neurologic impairment and a variety of injury patterns at presentation. This secondary analysis of prospectively collected... read more

Presenting Characteristics Associated With Outcome in Children With Severe TBI