Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects

Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects

Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects, Third Edition, is the only pocket-sized, quick reference for pathology and transfusion medicine residents and fellows. It covers all topics in transfusion... read more

The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill

The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill

Transfusion of red blood cells is an everyday practice in critical care with the primary aim of restoring adequate tissue oxygenation. However, blood transfusion may also be harmful and costly, therefore a so called restrictive... read more

Pretreating red blood cells with nitric oxide may reduce side effect linked to transfusions

Pretreating red blood cells with nitric oxide may reduce side effect linked to transfusions

A new treatment may diminish a dangerous side effect associated with transfusions of red blood cells (RBCs) known as pulmonary hypertension, an elevated blood pressure in the lungs and heart that can lead to heart failure.... read more

To transfuse or not transfuse: an intensive appraisal of red blood cell transfusions in the ICU

To transfuse or not transfuse: an intensive appraisal of red blood cell transfusions in the ICU

A restrictive transfusion threshold is recommended in nearly all critically ill patients. This is at least noninferior to more liberal transfusion practice; in addition, a restrictive threshold has shown improved outcomes... read more

Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections

Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections

In this randomized, clinical pilot trial of patients undergoing emergency surgery for thoracic aorta dissections, we found that OctaplasLG reduced glycocalyx and endothelial injury, reduced bleeding, transfusions, use of... read more

Indications and Outcomes of Extracorporeal Life Support in Trauma Patients

Indications and Outcomes of Extracorporeal Life Support in Trauma Patients

Data from the largest registry of critically ill trauma patients receiving extracorporeal life support (ECLS) demonstrates reasonable survival. With growing experience and improved safety profile, trauma should not be considered... read more

Thromboelastography Predicts Thromboembolism in Critically Ill Coagulopathic Patients

Thromboelastography Predicts Thromboembolism in Critically Ill Coagulopathic Patients

Critically ill patients with deranged conventional coagulation tests are often perceived to have an increased bleeding risk. Whether anticoagulant prophylaxis for these patients should be withheld is contentious. This study... read more

RBC Transfusions Are Associated With Prolonged Mechanical Ventilation in Pediatric ARDS

RBC Transfusions Are Associated With Prolonged Mechanical Ventilation in Pediatric ARDS

RBC transfusion was independently associated with longer duration of mechanical ventilation in pediatric acute respiratory distress syndrome. Hemoglobin transfusion thresholds should be tested specifically within pediatric... read more

No Bleeding Required: Anemia Detection via Smartphone

No Bleeding Required: Anemia Detection via Smartphone

Biomedical engineers have developed a smartphone app with the aim of non-invasive detection of anemia. Instead of a blood test, the app uses photos of someone's fingernails taken on a smartphone to determine whether the level... read more

Mortality of civilian patients with suspected traumatic hemorrhage receiving pre-hospital transfusion of packed red blood cells compared to pre-hospital crystalloid

Mortality of civilian patients with suspected traumatic hemorrhage receiving pre-hospital transfusion of packed red blood cells compared to pre-hospital crystalloid

In a single centre UK HEMS study, in patients with suspected traumatic hemorrhage who received a PRBC transfusion there was an observed, but non-significant, reduction in mortality at 6 h and 28 days, also reflected in... read more

Plasma Volume, Tissue Oedema, and the Steady-state Starling Principle

Plasma Volume, Tissue Oedema, and the Steady-state Starling Principle

The Michel–Weinbaum steady-state Starling principle has important consequences for clinical practice. The hope that biophysical intravascular colloid therapy with albumin or plasma substitutes can deliver plasma volume... read more

Whole Blood – More than the Sum of Its Components?

This retrospective analysis was conducted in a US Military population across 6 combat hospitals in Iraq and Afghanistan between January 2004 and October 2007. Patient's transfused at least 1 unit RBCs met inclusion criteria... read more

Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children

Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children

Early noninvasive ventilation combined with nonroutine transfusion is well tolerated in acute chest syndrome in children and may spare transfusion in some patients. Early recognition of patients still requiring transfusion... read more

Emergency Management of Intracerebral Hemorrhage – The Golden Hour

Emergency Management of Intracerebral Hemorrhage – The Golden Hour

There is a kind of self-fulfilling prognostic pessimism when it comes to Intracerebral Hemorrhage. And this pessimism sometimes leads to less than optimal care in patients who otherwise might have had a reasonably good outcome... read more