Balanced Solution vs. 0.9% Saline Solution Fluid Treatment in Critically Ill Patients

Among critically ill patients requiring fluid challenges, use of a balanced solution compared with 0.9% saline solution did not significantly reduce 90-day mortality. The findings do not support the use of this balanced... read more

Balanced Solution vs. 0.9% Saline Solution Fluid Treatment in Critically Ill Patients

Convalescent Plasma for COVID-19 in Hospitalised Patients

Convalescent plasma (CP) and standard of care (SOC) did not result in a higher proportion of clinical improvement on at day 28 in hospitalised patients with COVID-19 compared to SOC alone. This is an investigator-initiated,... read more

Convalescent Plasma for COVID-19 in Hospitalised Patients

When COVID-19 Complicates Other Diagnoses

The medical community is rapidly trying to identify complications and patterns of disease to improve patient outcomes as the COVID-19 pandemic continues. Numerous studies have shown varying degrees of liver damage in... read more

When COVID-19 Complicates Other Diagnoses

Targeting Cellular Signalling Pathways in Lung Diseases

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies... read more

Targeting Cellular Signalling Pathways in Lung Diseases

COVID-19 Variant Classifications and Definitions

Genetic variants of SARS-CoV-2 have been emerging and circulating around the world throughout the COVID-19 pandemic. Viral mutations and variants in the United States are routinely monitored through sequence-based surveillance,... read more

COVID-19 Variant Classifications and Definitions

Inhaled Budesonide Improves Time to COVID-19 Recovery

Inhaled budesonide improves time to recovery, with a chance of also reducing hospital admissions or deaths (although our results did not meet the superiority threshold), in people with COVID-19 in the community who are at... read more

Inhaled Budesonide Improves Time to COVID-19 Recovery

Impact of ABCDE Bundle Implementation in the ICU on Specific Patient Costs

Full ABCDE bundle implementation resulted in a decrease in total hospital laboratory costs and total hospital laboratory and diagnostic resource utilization while leading to an increase in physical therapy costs. The full... read more

Impact of ABCDE Bundle Implementation in the ICU on Specific Patient Costs

Fungal Infections Complicating COVID-19

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread globally to pandemic proportions. Although the majority of cases have asymptomatic or mild infections,... read more

Fungal Infections Complicating COVID-19

COVID-19 Variants in Patients with Immunosuppression

Patients with immunosuppression are at risk for prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In several case reports, investigators have indicated that multimutational SARS-CoV-2... read more

COVID-19 Variants in Patients with Immunosuppression

Milrinone vs. Dobutamine in the Treatment of Cardiogenic Shock

In patients with cardiogenic shock, no significant difference between Milrinone and Dobutamine was found with respect to the primary composite outcome or important secondary outcomes. A total of 192 participants (96 in... read more

Milrinone vs. Dobutamine in the Treatment of Cardiogenic Shock

The Harriet Lane Handbook: Mobile Medicine Series

Written "by residents, for residents" and reviewed by expert faculty at The Johns Hopkins Hospital, Lauren Kahl, MD and Helen K. Hughes, MD, MPH, The Harriet Lane Handbook, 21st Edition, remains your #1 source of pediatric... read more

The Harriet Lane Handbook: Mobile Medicine Series

Variations in End-of-Life Practices in ICUs Worldwide

Limitation of life-sustaining therapies is common worldwide with regional variability. Withholding treatment is more common than withdrawing treatment. Variations in type, frequency, and timing of end-of-life decisions were... read more

Variations in End-of-Life Practices in ICUs Worldwide

Red Book: Report of the Committee on Infectious Diseases

Extending an 8-decade tradition of excellence, Red Book® provides the most reliable and clinically useful information on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious... read more

Red Book: Report of the Committee on Infectious Diseases

Eosinophilic Esophagitis

Once considered a rare condition, eosinophilic esophagitis is now one of the most common conditions diagnosed during the assessment of feeding problems in children and during the evaluation of dysphagia and food impaction... read more

Eosinophilic Esophagitis

Carotid Blowout Syndrome: Modern Trends in Management

Carotid blowout syndrome (CBS) refers to rupture of the carotid artery and is an uncommon complication of head and neck cancer that can be rapidly fatal without prompt diagnosis and intervention. CBS develops when a damaged... read more

Carotid Blowout Syndrome: Modern Trends in Management

Electrical Storm and Incessant Ventricular Tachycardia

Electrical storm, also referred to as arrhythmic storm, refers to multiple recurrences of ventricular arrhythmias over a short period of time. In most instances, the arrhythmia is ventricular tachycardia (VT), but polymorphic... read more

Electrical Storm and Incessant Ventricular Tachycardia

Intensive care–treated cardiac arrest: a retrospective study on the impact of extended age on mortality, neurological outcome, received treatments and healthcare-associated costs

The elderly ICU-treated CA patients in this study had worse neurological outcomes, higher mortality and lower cost-effectiveness than younger patients. Elderly received less intense treatment. Further efforts are needed... read more

Intensive care–treated cardiac arrest: a retrospective study on the impact of extended age on mortality, neurological outcome, received treatments and healthcare-associated costs

COVID-19: a boost for intensive care authorship?

Almost 180 million cases of COVID-19 have been diagnosed, with almost 4.000.000 deaths. Since this pandemic had unprecedented worldwide healthcare and socio-economic effects, the scientific world is under exceptional pressure... read more

COVID-19: a boost for intensive care authorship?

The Gut in COVID‑19

In the last year, a growing number of articles addressed coronavirus disease 2019 (COVID-19), including its link with gastrointestinal (GI) (dys)function. We here highlight the most important findings regarding the role of... read more

The Gut in COVID‑19

Transcatheter arterial embolization for severe blunt liver injury in hemodynamically unstable patients

Transcatheter arterial embolization (TAE) in hemodynamically unstable patients who responded to initial infusion therapy to some extent has acceptable in-hospital mortality and clinical failure rates. Hemodynamic instability... read more

Transcatheter arterial embolization for severe blunt liver injury in hemodynamically unstable patients

Effect of Graded Early Mobilization on Psychomotor Status and Length of ICU Stay in Mechanically Ventilated Patients

This research showed that graded early mobilization was highly effective to improve the motor and psychological status of mechanically ventilated patients and reduce their length of ICU stay. In the control group mean... read more

Effect of Graded Early Mobilization on Psychomotor Status and Length of ICU Stay in Mechanically Ventilated Patients