Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more

Ivermectin Not the Crisis It’s Claimed to Be

Ivermectin Not the Crisis It’s Claimed to Be

I can't remember any time when the U.S. Food and Drug Administration had to resort to the faux-folksy mode of expression to try to get its point across. We live in strange times. The FDA was responding, of course, to the... read more

Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis

Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis

We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov... read more

Acute Eosinophilic Pneumonia Secondary to Daptomycin

Acute Eosinophilic Pneumonia Secondary to Daptomycin

Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after... read more

How protein-based COVID vaccines could change the pandemic

How protein-based COVID vaccines could change the pandemic

Unlike the relatively new technologies that the mRNA and viral-vector COVID-19 shots are based on, protein vaccines have been used for decades to protect people from hepatitis, shingles and other viral infections. To... read more

Mechanically Ventilated COVID-19 Patients: Long-term Survival Study

Mechanically Ventilated COVID-19 Patients: Long-term Survival Study

The long-term survival of mechanically ventilated patients with severe COVID-19 reaches more than 50% and may help to provide individualized risk stratification and potential treatments. 868 patients were included (median... read more

Essentials of Aerosol Therapy in Critically Ill Patients

Essentials of Aerosol Therapy in Critically Ill Patients

This book assesses the most appropriate forms of aerosol therapy for critically ill patients. Aerosol therapy is applied for the treatment of several pulmonary diseases in addition to some promising applications intended... read more

Fluvoxamine COVID-19 Treatment: Positive Impact on Patient Survival

Fluvoxamine COVID-19 Treatment: Positive Impact on Patient Survival

Fluvoxamine treatment in addition to the standard therapy in hospitalised ICU COVID-19 patients could have a positive impact on patient survival. Further studies on the effects of fluvoxamine in COVID-19 patients are urgently... read more

COVID-19-related Death in Fully Vaccinated People in Scotland – Characteristics and Risk

COVID-19-related Death in Fully Vaccinated People in Scotland – Characteristics and Risk

Vaccines are highly effective in preventing COVID-19 hospitalisations and deaths. COVID-19-related deaths in fully vaccinated individuals have, however, been reported. To inform public health strategy and vaccination... read more

Early COVID-19 Treatment with SARS-CoV-2 Neutralizing Antibody Sotrovimab

Early COVID-19 Treatment with SARS-CoV-2 Neutralizing Antibody Sotrovimab

Among high-risk patients with mild-to-moderate COVID-19, sotrovimab reduced the risk of disease progression. No safety signals were identified. The results of this interim analysis of COMET-ICE indicate that sotrovimab... read more

Risk of Death in Hospitalised COVID‐19 Patients Is Not Reduced by Azithromycin Treatment

Risk of Death in Hospitalised COVID‐19 Patients Is Not Reduced by Azithromycin Treatment

The effect of antibiotics with potential antiviral and anti‐inflammatory properties are being investigated in clinical trials as treatment for COVID‐19. We are certain that risk of death in hospitalised COVID‐19... read more

CAPSID Randomized Trial Results for High-dose Convalescent Plasma in COVID-19 Patients

CAPSID Randomized Trial Results for High-dose Convalescent Plasma in COVID-19 Patients

COVID-19 convalescent plasma (CCP) has been considered a treatment option for COVID-19. This trial assessed the efficacy of a neutralizing antibody containing high-dose CCP in hospitalized adults with COVID-19 requiring respiratory... read more

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

The ongoing pandemic could affect the duration, variety and severity of the mental, physical, and cognitive impairments intensive care unit (ICU) survivors and their families frequently present. We aim to determine the impact... read more

Prehospital FAST Reduces Admission Time and Treatment

Prehospital FAST Reduces Admission Time and Treatment

The focused assessment with sonography in trauma (FAST) exam is an established trauma care diagnostic procedure. Ultrasound performed during prehospital care can improve early treatment and management of the patients. According... read more

Carbapenem Antibiotics for the Empiric Treatment of Nosocomial Pneumonia

Carbapenem Antibiotics for the Empiric Treatment of Nosocomial Pneumonia

Carbapenem-based empiric regimens were associated with lower mortality rates compared with non-carbapenems, largely driven by trials of ventilator-associated pneumonia (VAP). The mortality effect was not observed in trials... read more

COVID-19 Handbook: Navigating the Future of Healthcare

COVID-19 Handbook: Navigating the Future of Healthcare

The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more

ECMO for COVID-19

ECMO for COVID-19

Mortality after ECMO for patients with COVID-19 worsened during 2020. These findings inform the role of extracorporeal membrane oxygenation (ECMO) in COVID-19 for patients, clinicians, and policy makers. In 2020, 4,812... read more