Acute Hyperglycemic Emergencies

As diabetes prevalence increases in the US, critical care nurses need to be familiar with the acute hyperglycemic emergencies they may encounter in the ED or ICU. This article focuses on the diagnosis of, various treatments... read more

Acute Hyperglycemic Emergencies

Intrathoracic Pressure Regulation Therapy Applied to Ventilated Patients for Treatment of Compromised Cerebral Perfusion from Brain Injury

These data support the notion that active intrathoracic pressure regulation, in this limited evaluation, can successfully augment cerebral perfusion by lowering intracranial pressure and increasing mean arterial pressure... read more

Intrathoracic Pressure Regulation Therapy Applied to Ventilated Patients for Treatment of Compromised Cerebral Perfusion from Brain Injury

Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock

In this meta-analysis, the addition of vasopressin to catecholamine vasopressors compared with catecholamines alone was associated with a lower risk of atrial fibrillation. However, findings for secondary outcomes varied.... read more

Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock

How Should We Relate to Unreasonable Families in the ICU?

Most families have never suffered through a loved one experiencing prolonged critical illness and respiratory failure (defined as ventilator dependence for weeks, usually with a tracheostomy). But each year, more do. An estimated... read more

How Should We Relate to Unreasonable Families in the ICU?

Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy

Small size central vascular catheters display optimal rheologic performances in terms of pressures and flows particularly when the renal replacement therapy (RRT) device is equipped with pumps proportional to central vascular... read more

Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury

Update of the Brain Trauma Foundation Guidelines, Third Edition. Severe Traumatic Brain Injury in Infants, Children, and Adolescents in 2019: Some Overdue Progress, Many Remaining Questions, and Exciting Ongoing Work in the... read more

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury

ECMO in the Critical Trauma Patient

Growing evidence suggests the potential use of Extracorporeal membrane oxygenation (ECMO) for the treatment of refractory respiratory failure in adults, but the clinical benefit in polytraumatic patients is not clear. The... read more

ECMO in the Critical Trauma Patient

How Artificial Intelligence Can Make Healthcare Human Again

Medicine has become inhuman, to disastrous effect. The doctor-patient relationship, the heart of medicine, is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and... read more

How Artificial Intelligence Can Make Healthcare Human Again

Potassium Homoeostasis and Pathophysiology of Hyperkalaemia

Since determination of potassium levels may be afflicted with various errors, potassium levels should be determined using a standardized set-up ensuring high accuracy and precision of measurements. Potassium levels may be... read more

Potassium Homoeostasis and Pathophysiology of Hyperkalaemia

Procalcitonin Reduces Antibiotic Use with No Negative Outcomes

The elderly patient presenting to the ED with nonspecific symptoms remains a diagnostic and therapeutic challenge. Often, these patients arrive with general complaints ranging from altered mental status to weakness, subjective... read more

Procalcitonin Reduces Antibiotic Use with No Negative Outcomes

Catheter Directed Thrombolysis for Intermediate Risk Pulmonary Embolism

Intermediate risk pulmonary embolism is common and carries a risk of progression to hemodynamic collapse and death. Catheter directed thrombolysis is an increasingly utilized treatment option, based largely on the assumptions... read more

Catheter Directed Thrombolysis for Intermediate Risk Pulmonary Embolism

Antibiotic timing in Severe Sepsis

Severe sepsis is a time dependent condition and this study builds on previous literature which supports that early identification and treatment of sepsis with antibiotics decreases mortality. Retrospective analysis of a large... read more

Antibiotic timing in Severe Sepsis

Number Needed to Treat

Effectively communicating clinical trial results to patients and clinicians is a requirement for appropriate application in clinical practice. In a recent issue of JAMA, Zhao et al1 reported the results from a randomized... read more

Number Needed to Treat

Prehospital Intravenous Fentanyl Administered by Ambulance Personnel

Prehospital acute pain is a frequent symptom that is often inadequately managed. The concerns of opioid induced side effects are well-founded. To ensure patient safety, ambulance personnel are therefore provided with treatment... read more

Prehospital Intravenous Fentanyl Administered by Ambulance Personnel

Hypertriglyceridemic pancreatitis: Can we defuse the bomb?

Hypertriglyceridemia causes ~9% of pancreatitis, the third most common cause after alcohol and gallstones. It is a risk factor for severe pancreatitis, making it more frequent among ICU patients with pancreatitis. I see... read more

Hypertriglyceridemic pancreatitis: Can we defuse the bomb?

Antifungal Treatment in the ICU

Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in critically ill patients. Almost 80% of IFIs are due to Candida spp., which are the third most common isolated microorganisms in the intensive... read more

Antifungal Treatment in the ICU

Electrophysiological Investigations of Peripheral Nerves and Muscles

Resting trans-membrane potential difference (Em) of skeletal muscle is correlated to the energy status of the organism: the more severe the illness, the lower the Em. In 1971, Cunningham demonstrated this association with... read more

Electrophysiological Investigations of Peripheral Nerves and Muscles

Hoopla Aside, hs-cTnI is Not Catching Missed Mis

We have been searching for a tool to identify myocardial infarction patients who are truly safe for discharge ever since Pope, et al., found that we were discharging two percent of patients with MIs from the emergency department.... read more

Hoopla Aside, hs-cTnI is Not Catching Missed Mis

Aid Tool Does Not Help Care Decisions in Prolonged Mechanical Ventilation

Treatment decisions commonly have to be made in intensive care units (ICUs). These decisions are difficult for surrogate decision makers and often lead to decisional conflict, psychological distress, and treatments misaligned... read more

Aid Tool Does Not Help Care Decisions in Prolonged Mechanical Ventilation

The Artificial Intelligence Clinician Learns Optimal Treatment Strategies for Sepsis in Intensive Care

Sepsis is the third leading cause of death worldwide and the main cause of mortality in hospitals but the best treatment strategy remains uncertain. In particular, evidence suggests that current practices in the administration... read more

The Artificial Intelligence Clinician Learns Optimal Treatment Strategies for Sepsis in Intensive Care

Optimizing Patient and Family Education Resources for the ICU

Offering stronger patient and family education tools in the ICU will ease patient and caregiver fears and make them more comfortable with the care setting. An integrated, centralized, and digital platform is best suited for... read more

Optimizing Patient and Family Education Resources for the ICU