Management of Septic Shock

Management of Septic Shock

The results of the PRISM trials confirm that early intervention strategies, including early detection of sepsis, risk stratification, early administration of antibiotics, and appropriate fluid resuscitation, improve the outcomes... read more

WHO tries to keep certain antibiotics largely off the table

In a bid to battle antibiotic resistance, the World Health Organization for the first time has classified antibiotics into three categories, including one that lists the drugs it hopes will not be used except in circumstances... read more

Diagnosis, Prevention, and Treatment of C. difficile: Current State of the Evidence

Diagnosis, Prevention, and Treatment of C. difficile: Current State of the Evidence

This is a summary of a systematic review that evaluated the recent evidence regarding the accuracy of diagnostic tests and the effectiveness of interventions for preventing and treating Clostridium difficile (C. difficile)... read more

ER Overcrowding Delays Sepsis Treatment

ER Overcrowding Delays Sepsis Treatment

Prompt antibiotic initiation is associated with improved mortality in sepsis and septic shock. However, new research shows that patients with sepsis, a life-threatening complication of an infection, had delays approaching... read more

Personalised Medicine in Intensive Care

Personalised Medicine in Intensive Care

The specialty of intensive care medicine grew out of the realisation that critically ill patients needed more attention and specialised treatment than could be provided on a general ward, and that many of these patients had... read more

ICU Medicine Is a Team Sport

ICU Medicine Is a Team Sport

I am incredibly fortunate to work on a multidisciplinary team every day. The team includes respiratory therapists, nurses, nutritionists, attending physicians (APs), and advanced practice providers (APPs) (nurse practitioners... read more

WHA Adopts Resolution on Sepsis

World Health Assembly and the World Health Organization made sepsis a global health priority, by adopting a resolution to improve, prevent, diagnose, and manage sepsis. This marks a quantum leap in the global fight against... read more

What emotions are doctors allowed to feel?

What emotions are doctors allowed to feel?

As a medical professional, struggle between feeling too much and feeling too little is constant. Feelings are a double edged sword in medicine - many times they can shake you or beat you down. After two years, I know this:... read more

Exosomes in Critical Illness

Exosomes in Critical Illness

Exosomes are small, cell-released vesicles (40–100 nm in size) with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells via interstitial fluids. Due to their role in tissue homeostasis,... read more

Early EEG for outcome prediction of postanoxic coma

Early EEG for outcome prediction of postanoxic coma

We recently showed that electroencephalography (EEG) patterns within the first 24 hours robustly contribute to multimodal prediction of poor or good neurological outcome of comatose patients after cardiac arrest. Here, we... read more

Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock

Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock

The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine... read more

Neuro ICU Early Mobilization Protocol

Neuro ICU Early Mobilization Protocol

Researchers in the U.S. have developed a multidisciplinary Neuro Early Mobilization Protocol for complex patients in the neuroscience intensive care unit (NSICU). Developing an evidence-based protocol with inter-professional... read more

Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome

Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome

Current pharmacologic treatment of the neonatal abstinence syndrome with morphine is associated with a lengthy duration of therapy and hospitalization. Buprenorphine may be more effective than morphine for this indication.... read more

A Breakthrough Oxygen Therapy May Be Able to Reverse Brain Damage

A Breakthrough Oxygen Therapy May Be Able to Reverse Brain Damage

New research shows that low oxygen therapy is able to eliminate brain lesions developed from mitochondrial dysfunction in mice. Eventually, hypoxia therapy could be used to treat people with similar disorders and maybe even... read more

Why digital disruption is only starting in healthcare

Disruption often is viewed as a positive noun in the business world. Particularly in healthcare, such disruption can result in increased understanding and enhanced outcomes, among other benefits. Healthcare has clearly... read more

Happy 100th Anniversary to the RSNA

Happy 100th Anniversary to the RSNA

This week the Radiological Society of North America, a.k.a. RSNA, is holding its annual meeting in Chicago. RSNA is an international society of radiologists, medical physicists and other medical professionals with more than... read more

Effect of Reminder Devices on Medication Adherence

Effect of Reminder Devices on Medication Adherence

In this randomized clinical trial of 53 480 enrollees of a pharmacy benefit manager, no statistically significant difference in adherence was found between those in the control group and those who received a reminder device... read more