Tag: treatment
Haloperidol vs. Placebo in ICU Patients with Delirium
We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. In acutely admitted adult ICU patients with delirium, haloperidol treatment... read more
Critical Care: A New Nurse Faces Death, Life, and Everything in Between
Doctors heal, or try to, but as nurses we step into the breach, figure out what needs to be done for any given patient today, on this shift, and then, with love and exasperation, do it as best as we can. Critical Care... read more
Ilofotase Alfa Doesn’t Improved Survival Among Critically Ill Patients with SA-AKI
Sepsis-associated acute kidney injury (SA-AKI) in patients admitted to an intensive care unit is associated with significant morbidity and mortality. There is currently no pharmaceutical treatment. Although we found no... read more
Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Patients with AHRF
This study suggests that high-flow nasal cannula (HFNC) therapy in general respiratory wards may be a potential rescue therapy for patients with respiratory failure. Electrical impedance tomography (EIT) potentially monitors... read more
Oxygenation Improvement in Hyperinflammatory Ovine ARDS Treated with Methylprednisolone
Early and persistent improvement in oxygenation was seen only in hyperinflammatory ovine ARDS treated with methylprednisolone, while hemodynamic situation and survival was improved in both injury models and corticosteroid... read more
Inflammatory Subphenotypes in Patients at Risk of ARDS
We identified hyper- and non-hyperinflammatory subphenotypes in patients at risk of ARDS upon presentation to the emergency department. These subphenotypes remained identifiable over time and a hyperinflammatory subphenotype... read more
Effect of Mechanical Ventilation Under Intubation on Respiratory Tract Change of Bacterial Count
Mechanical ventilation under intubation may cause dysregulation of lower respiratory microbiota in rats. The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with... read more
Haloperidol Efficacy to Decrease Delirium Burden in Critically Ill Patients
This trial, that was stopped early, did not show evidence that haloperidol reduces delirium and coma in critically ill patients with delirium. The beneficial effects on some agitation-related outcomes and lower sedative... read more
Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation
Delirium treatment with haloperidol and/or pipamperone was not associated with a higher risk of QTc-interval prolongation in this naturalistic patient sample but was greater in magnitude and correlated with equipotent dosage... read more
Hyperlipidemia in Immune Thrombocytopenia
A high proportion of ITP patients suffered from metabolic disorders, especially hyperlipidemia. Patients with hyperlipidemia may have more severe bleeding symptoms and worse responses to ITP treatments. Statin may help... read more
Uncommon Diseases in the ICU
This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon... read more
Long COVID Associated with Reduced Circulating Serotonin Levels
Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated... read more
Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients
Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more
Roadblock: AFib with RVR
In this paper we focus on strategies to bypass the most common pitfalls in our treatment algorithm when treating patients who present to the ED in atrial fibrillation with RVR. We all know the few medications in our toolbox... read more
What to Know About Merkel Cell Carcinoma, the Rare Cancer that Killed Jimmy Buffett
"Margaritaville" singer Jimmy Buffett died of Merkel cell carcinoma, a rare but aggressive form of skin cancer, according to a tribute posted on his official websiteopens in a new tab or window. The 76-year-old music icon... read more
Urine Output-based Sepsis-associated AKI: Clinical Implications
This paper offers comprehensive insights into the epidemiology of acute kidney injury (AKI), and we commend the authors for their significant contribution. They revealed an increase in the number of mild cases among AKI stage... read more
TXA Should be Urgently and Broadly Adopted for Brain Bleeds
Everything looked better with tranexamic acid (TXA), and none of it was statistically significant. True, in a subgroup analysis of patients who actually had a head bleed on imaging—which, gee whiz, seems like an important... read more
Renal Replacement Therapy: Controversies and Future Trends
Controversies and trends have always been present in nephrology. Since its inception and throughout its development, renal replacement therapy has been shrouded in uncertainty, even as it advances, and it has always been... read more
Delirium in Critically Ill Patients – Haloperidol Treatment
Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more
Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage
In this study of critically injured trauma patients with major hemorrhage, artesunate did not improve organ dysfunction and was potentially associated with an increased VTE risk. Future studies that focus on immune responses... read more
Adjunctive Intravenous Then Oral Vitamin C for CAP Patients
Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient... read more
