TXA Should be Urgently and Broadly Adopted for Brain Bleeds

TXA Should be Urgently and Broadly Adopted for Brain Bleeds

Everything looked better with tranexamic acid (TXA), and none of it was statistically significant. True, in a subgroup analysis of patients who actually had a head bleed on imaging—which, gee whiz, seems like an important... read more

Renal Replacement Therapy: Controversies and Future Trends

Renal Replacement Therapy: Controversies and Future Trends

Controversies and trends have always been present in nephrology. Since its inception and throughout its development, renal replacement therapy has been shrouded in uncertainty, even as it advances, and it has always been... read more

Delirium in Critically Ill Patients – Haloperidol Treatment

Delirium in Critically Ill Patients – Haloperidol Treatment

Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more

Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage

Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage

In this study of critically injured trauma patients with major hemorrhage, artesunate did not improve organ dysfunction and was potentially associated with an increased VTE risk. Future studies that focus on immune responses... read more

Adjunctive Intravenous Then Oral Vitamin C for CAP Patients

Adjunctive Intravenous Then Oral Vitamin C for CAP Patients

Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient... read more

Updated Systematic Review on Remdesivir’s Safety and Efficacy in COVID-19 Patients

Updated Systematic Review on Remdesivir’s Safety and Efficacy in COVID-19 Patients

Remdesivir, an antiviral medication, may benefit patients who are infected with mild or moderate forms of COVID-19 infection. Several research findings have suggested the safety and efficacy of remdesivir for a five- to 10-day... read more

Handbook for Venous Thromboembolism

Handbook for Venous Thromboembolism

A truly practical guidebook for anyone who needs the key information on the diagnosis, management and prevention of venous thromboembolism. Specific areas of focus include understanding the risk factors for VTE and the role... read more

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery

Right ventricular failure (RVF) is a leading driver of morbidity and mortality after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation.... read more

Optimal Fluid Therapy for Sepsis Management in Critically Ill Adults

Optimal Fluid Therapy for Sepsis Management in Critically Ill Adults

For a study, researchers aimed to analyze the fluid treatment in septic critically ill adults. About 20% to 30% of patients were admitted to an ICU with sepsis. In sepsis patients, investigators observed intravenous fluid... read more

Minimally Invasive Intrathoracic Negative-pressure Therapy and FlexVATS for Patients with Pleural Empyema

Minimally Invasive Intrathoracic Negative-pressure Therapy and FlexVATS for Patients with Pleural Empyema

To determine whether a new surgical method using a flexible endoscope (FlexVATS) to perform sparing debridement and apply negative-pressure therapy without extensive decortication may be an alternative treatment option for... read more

Propofol in ICU Settings: Understanding and Managing Anti-Arrhythmic, Pro-Arrhythmic Effects, and Propofol Infusion Syndrome

Propofol in ICU Settings: Understanding and Managing Anti-Arrhythmic, Pro-Arrhythmic Effects, and Propofol Infusion Syndrome

Propofol has revolutionized anesthesia and intensive care medicine owing to its favorable pharmacokinetic characteristics, fast onset, and short duration of action. This drug has been shown to be remarkably effective in numerous... read more

Early Control of Elevated Blood Pressure – INTERACT3

Early Control of Elevated Blood Pressure – INTERACT3

Early control of elevated blood pressure is the most promising treatment for acute intracerebral hemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols for early intensive... read more

Heparin-Binding Protein Predictive Value and D-Dimer in Sepsis Patients

Heparin-Binding Protein Predictive Value and D-Dimer in Sepsis Patients

As common clinical indicators for predicting sepsis, both HBP and D-dimer have high diagnostic effectiveness. Furthermore, the combined application of these two biomarkers can achieve favorable effects. In clinical practice,... read more

Effective Treatment for Combined Amlodipine and Metformin Overdose

Effective Treatment for Combined Amlodipine and Metformin Overdose

The combined toxicity of amlodipine and metformin is a rarely reported phenomenon in the literature. The management varies depending on the clinical status of the patient. We present a case that was managed successfully... read more

Rapid Sepsis Tests Using Magnetic Nanoparticles

Rapid Sepsis Tests Using Magnetic Nanoparticles

Qun Ren, an Empa researcher, and her team are currently developing a diagnostic procedure that can rapidly detect life-threatening blood poisoning caused by staphylococcus bacteria. Staphylococcal sepsis is fatal in up... read more

Oxford Textbook of Critical Care

Oxford Textbook of Critical Care

The thoroughly revised 2nd edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely the book takes a problem-orientated approach... read more

Rescue TEE Might Diagnose Cardiac Arrest Faster

Rescue TEE Might Diagnose Cardiac Arrest Faster

A Penn Medicine team is testing whether a new technology that gives live ultrasound images from inside a patient during CPR can help doctors get those answers faster. The device, called Rescue TEE, uses a tiny camera at the... read more