Tag: treatment
Haloperidol Efficacy to Decrease Delirium Burden in Critically Ill Patients
This trial, that was stopped early, did not show evidence that haloperidol reduces delirium and coma in critically ill patients with delirium. The beneficial effects on some agitation-related outcomes and lower sedative... read more
Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation
Delirium treatment with haloperidol and/or pipamperone was not associated with a higher risk of QTc-interval prolongation in this naturalistic patient sample but was greater in magnitude and correlated with equipotent dosage... read more
Hyperlipidemia in Immune Thrombocytopenia
A high proportion of ITP patients suffered from metabolic disorders, especially hyperlipidemia. Patients with hyperlipidemia may have more severe bleeding symptoms and worse responses to ITP treatments. Statin may help... read more
Uncommon Diseases in the ICU
This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon... read more
Long COVID Associated with Reduced Circulating Serotonin Levels
Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated... read more
Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients
Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more
Roadblock: AFib with RVR
In this paper we focus on strategies to bypass the most common pitfalls in our treatment algorithm when treating patients who present to the ED in atrial fibrillation with RVR. We all know the few medications in our toolbox... read more
What to Know About Merkel Cell Carcinoma, the Rare Cancer that Killed Jimmy Buffett
"Margaritaville" singer Jimmy Buffett died of Merkel cell carcinoma, a rare but aggressive form of skin cancer, according to a tribute posted on his official websiteopens in a new tab or window. The 76-year-old music icon... read more
Urine Output-based Sepsis-associated AKI: Clinical Implications
This paper offers comprehensive insights into the epidemiology of acute kidney injury (AKI), and we commend the authors for their significant contribution. They revealed an increase in the number of mild cases among AKI stage... read more
TXA Should be Urgently and Broadly Adopted for Brain Bleeds
Everything looked better with tranexamic acid (TXA), and none of it was statistically significant. True, in a subgroup analysis of patients who actually had a head bleed on imaging—which, gee whiz, seems like an important... read more
Renal Replacement Therapy: Controversies and Future Trends
Controversies and trends have always been present in nephrology. Since its inception and throughout its development, renal replacement therapy has been shrouded in uncertainty, even as it advances, and it has always been... read more
Delirium in Critically Ill Patients – Haloperidol Treatment
Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more
Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage
In this study of critically injured trauma patients with major hemorrhage, artesunate did not improve organ dysfunction and was potentially associated with an increased VTE risk. Future studies that focus on immune responses... read more
Adjunctive Intravenous Then Oral Vitamin C for CAP Patients
Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient... read more
Updated Systematic Review on Remdesivir’s Safety and Efficacy in COVID-19 Patients
Remdesivir, an antiviral medication, may benefit patients who are infected with mild or moderate forms of COVID-19 infection. Several research findings have suggested the safety and efficacy of remdesivir for a five- to 10-day... read more
Handbook for Venous Thromboembolism
A truly practical guidebook for anyone who needs the key information on the diagnosis, management and prevention of venous thromboembolism. Specific areas of focus include understanding the risk factors for VTE and the role... read more
Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery
Right ventricular failure (RVF) is a leading driver of morbidity and mortality after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation.... read more
Optimal Fluid Therapy for Sepsis Management in Critically Ill Adults
For a study, researchers aimed to analyze the fluid treatment in septic critically ill adults. About 20% to 30% of patients were admitted to an ICU with sepsis. In sepsis patients, investigators observed intravenous fluid... read more
