COVID-19 Pandemic Effect on the Incidence and Survival Outcomes of EMS-witnessed OHCA

COVID-19 Pandemic Effect on the Incidence and Survival Outcomes of EMS-witnessed OHCA

While other international studies have observed higher incidence and reduced survival in non-EMS-witnessed out-of-hospital cardiac arrest (OHCA) during the COVID-19 pandemic, this study did not identify any significant impacts... read more

PLASMIC Score Role in the Management of Thrombotic Thrombocytopenic Purpura

PLASMIC Score Role in the Management of Thrombotic Thrombocytopenic Purpura

At centers that are resource-limited and where ADAMTS-13 testing is not readily available, it is imminent that treatment is started immediately based on the clinical presentation and PLASMIC score. A PLASMIC score can... read more

Oral PCSK9 Inhibitor Could Help Reduce LDL-C by 60%

Oral PCSK9 Inhibitor Could Help Reduce LDL-C by 60%

New research from a phase 2b trial presented at American College of Cardiology meeting (ACC) 2023 suggests an oral PCSK9 inhibitor could help reduce LDL-C by 60% in patients with or at-risk for atherosclerotic cardiovascular... read more

Advances in Microbiology, Infectious Diseases and Public Health: Volume 15

Advances in Microbiology, Infectious Diseases and Public Health: Volume 15

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues... read more

Emergence of Ventilator Associated Pneumonia in Critical Care Units

Emergence of Ventilator Associated Pneumonia in Critical Care Units

In intensive care unit, the care of critically ill patients is a primary component of modern medicine. Intensive care units create potential for recovery in patients who otherwise may not have survived. They are, however,... read more

Targeted Immunomodulation: A Primer for Intensivists

Targeted Immunomodulation: A Primer for Intensivists

Targeted immunomodulation is a topic that gained wide interest from translational researchers in the past decades, yet immunomodulatory drugs were not frequently administered to intensive care patients. The coronavirus... read more

Acute Lung Injury and Repair: Scientific Fundamentals and Methods

Acute Lung Injury and Repair: Scientific Fundamentals and Methods

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population. Several clinical disorders can initiate... read more

COVID-19 Treatment Guidelines New Version Published

COVID-19 Treatment Guidelines New Version Published

The COVID-19 Treatment Guidelines Panel (the Panel) is pleased to announce the publication of an updated version of the Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. In the United States, the prevalence of... read more

Interim Clinical Treatment Considerations for Severe Manifestations of Mpox

Interim Clinical Treatment Considerations for Severe Manifestations of Mpox

The Centers for Disease Control and Prevention (CDC) released a Morbidity and Mortality Weekly Report (MMWR) titled "Interim Clinical Treatment Considerations for Severe Manifestations of Mpox—United States, February 2023."... read more

Bempedoic Acid Associated with Lower Risk of Cardiovascular Events

Bempedoic Acid Associated with Lower Risk of Cardiovascular Events

Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or... read more

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices... read more

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

The study evaluated the use of heart rate variability (HRV) to predict the outcome of patients in the ICU. HRV is a way to evaluate the cardiac effects of the autonomic nervous system, and a relation between HRV and outcome... read more

Acute Effects of Ketamine on ICP in Children With Severe TBI

Acute Effects of Ketamine on ICP in Children With Severe TBI

In this retrospective, exploratory study, intracranial pressure (ICP) did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during... read more

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Pharmacologic treatment of COVID-19 has continued to evolve since the onset of the pandemic, and yet many questions remain about optimal treatment. Medicine strives to provide evidence-based guidance on treatments, but... read more