Advances in Microbiology, Infectious Diseases and Public Health: Volume 15

Advances in Microbiology, Infectious Diseases and Public Health: Volume 15

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues... read more

Emergence of Ventilator Associated Pneumonia in Critical Care Units

Emergence of Ventilator Associated Pneumonia in Critical Care Units

In intensive care unit, the care of critically ill patients is a primary component of modern medicine. Intensive care units create potential for recovery in patients who otherwise may not have survived. They are, however,... read more

Targeted Immunomodulation: A Primer for Intensivists

Targeted Immunomodulation: A Primer for Intensivists

Targeted immunomodulation is a topic that gained wide interest from translational researchers in the past decades, yet immunomodulatory drugs were not frequently administered to intensive care patients. The coronavirus... read more

Acute Lung Injury and Repair: Scientific Fundamentals and Methods

Acute Lung Injury and Repair: Scientific Fundamentals and Methods

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population. Several clinical disorders can initiate... read more

COVID-19 Treatment Guidelines New Version Published

COVID-19 Treatment Guidelines New Version Published

The COVID-19 Treatment Guidelines Panel (the Panel) is pleased to announce the publication of an updated version of the Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. In the United States, the prevalence of... read more

Interim Clinical Treatment Considerations for Severe Manifestations of Mpox

Interim Clinical Treatment Considerations for Severe Manifestations of Mpox

The Centers for Disease Control and Prevention (CDC) released a Morbidity and Mortality Weekly Report (MMWR) titled "Interim Clinical Treatment Considerations for Severe Manifestations of Mpox—United States, February 2023."... read more

Bempedoic Acid Associated with Lower Risk of Cardiovascular Events

Bempedoic Acid Associated with Lower Risk of Cardiovascular Events

Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or... read more

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

The study evaluated the use of heart rate variability (HRV) to predict the outcome of patients in the ICU. HRV is a way to evaluate the cardiac effects of the autonomic nervous system, and a relation between HRV and outcome... read more

Acute Effects of Ketamine on ICP in Children With Severe TBI

Acute Effects of Ketamine on ICP in Children With Severe TBI

In this retrospective, exploratory study, intracranial pressure (ICP) did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during... read more

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Pharmacologic treatment of COVID-19 has continued to evolve since the onset of the pandemic, and yet many questions remain about optimal treatment. Medicine strives to provide evidence-based guidance on treatments, but... read more

6 Days Higher-Dose Ivermectin vs. Placebo on Time to Sustained Recovery in COVID-19 Outpatients

6 Days Higher-Dose Ivermectin vs. Placebo on Time to Sustained Recovery in COVID-19 Outpatients

Among a largely vaccinated outpatient population with mild to moderate COVID-19, treatment with ivermectin, with a targeted maximum dose of 600 μg/kg daily for 6 days, compared with placebo was not shown to improve time... read more

Intracranial Pressure: Current Perspectives on Physiology and Monitoring

Intracranial Pressure: Current Perspectives on Physiology and Monitoring

Intracranial pressure (ICP) monitoring is now viewed as integral to the clinical care of many life-threatening brain insults, such as severe traumatic brain injury, subarachnoid hemorrhage, and malignant stroke. It serves... read more

Heterogeneity in Pediatric ARDS: Challenges and Complexities in Diagnosis and Treatment

Heterogeneity in Pediatric ARDS: Challenges and Complexities in Diagnosis and Treatment

Pediatric intensive care physicians are well-acquainted with the concept of heterogeneity, as the patients, pathologies, and treatments they encounter can vary greatly both within the pediatric intensive care unit and within... read more

Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients

Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients

Feed intolerance (FI) is common in critically-ill cirrhosis patients and non-resolution carries high mortality. Early recognition and treatment with prokinetics is recommended to improve short-term survival. Of the 1,030... read more

Plasma Exchange in the ICU

Plasma Exchange in the ICU

In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement... read more

Care Step Pathway an Effective Tool For Clinicians Caring for Mechanical Ventilated COVID-19 Patients

Care Step Pathway an Effective Tool For Clinicians Caring for Mechanical Ventilated COVID-19 Patients

The Care Step Pathway (CSP) described in this article was developed to increase awareness of the potential association of SARS-CoV-2 infection with invasive fungal infections, particularly pulmonary aspergillosis. The... read more

Intra-Abdominal Hypertension – Core Critical Care

Intra-Abdominal Hypertension – Core Critical Care

The most popular book at ISICEM meeting. Despite increasing interest in intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as causes of significant morbidity and mortality among the critically ill,... read more