Effects of Patient-Directed Music Intervention on Anxiety and Sedative Exposure in Critically Ill Patients Receiving Mechanical Ventilatory Support

Effects of Patient-Directed Music Intervention on Anxiety and Sedative Exposure in Critically Ill Patients Receiving Mechanical Ventilatory Support

Among ICU patients receiving acute ventilatory support for respiratory failure, patient-directed music (PDM) resulted in greater reduction in anxiety compared with usual care, but not compared with NCH. Concurrently, PDM... read more

Using music to stabilize NICU babies as well as their parents

Using music to stabilize NICU babies as well as their parents

When music therapist Christine Vaskas works with babies in the neonatal intensive care unit, the effect of her interventions are almost always immediately apparent. In 2013, a study led by Joanne Loewy, the Armstrong Center's... read more

Lumping or Splitting in Pediatric ARDS

Lumping or Splitting in Pediatric ARDS

Improvements in acute respiratory distress syndrome (ARDS) outcomes in adults have been achieved along-side demonstration of the superiority of low-tidal volume ventilation, the relative advantage of a restrictive fluid strategy... read more

Time-limited Trial of Intensive Care Treatment

Time-limited Trial of Intensive Care Treatment

In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition,... read more

New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections

New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections

Only few new molecules have an adequate activity against MDR gram-negative pathogens, especially carbapenemase-producer strains. Among these, ceftozolane/tazobactam has been recently approved for clinical use. Other compounds,... read more

Effect of Early vs Delayed Initiation of RRT on Mortality in Critically Ill Patients With AKI

Effect of Early vs Delayed Initiation of RRT on Mortality in Critically Ill Patients With AKI

Among critically ill patients with Acute Kidney Injury (AKI), early Renal Replacement Therapy (RRT) compared with delayed initiation of RRT reduced mortality over the first 90 days. Further multicenter trials of this intervention... read more

Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation

Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation

Among patients with severe secondary mitral regurgitation, the rate of death or unplanned hospitalization for heart failure at 1 year did not differ significantly between patients who underwent percutaneous mitral-valve repair... read more

Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Haemoglobin concentration decreases during resuscitation from septic shock, and has a significant but weak association with the volume of intravenous fluids administered. Median (IQR) haemoglobin concentration at baseline... read more

The Danger Within Us: America’s Untested, Unregulated Medical Device Industry and One Man’s Battle to Survive It

The Danger Within Us: America’s Untested, Unregulated Medical Device Industry and One Man’s Battle to Survive It

In THE DANGER WITHIN US, award-winning journalist Jeanne Lenzer brings these horrifying statistics to life through the story of one working class man who, after his "cure" nearly kills him, ends up in a battle for justice... read more

It Makes No Difference – Glucocorticoids for the Treatment of Septic Shock

It Makes No Difference – Glucocorticoids for the Treatment of Septic Shock

The administration of a continuous infusion of hydrocortisone to a general population of patients in septic shock on mechanical ventilation cannot be recommended at this time. The authors conclusion that glucocorticoids do... read more

Watchdog Group Calls for NIH to Halt Dangerous Study of Sepsis Treatment

A medical watchdog group is calling on the National Institutes of Health to immediately stop the enrollment of patients in a clinical trial of sepsis treatment and launch an investigation of how the study received approval,... read more

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

In patients with endocarditis on the left side of the heart who were in stable condition, changing to oral antibiotic treatment was noninferior to continued intravenous antibiotic treatment. After randomization, antibiotic... read more

The Cumulative Effect of Reporting and Citation Biases on the Apparent Efficacy of Treatments: The Case of Depression

The Cumulative Effect of Reporting and Citation Biases on the Apparent Efficacy of Treatments: The Case of Depression

The problem of study publication bias is well-known. Our examination of antidepressant trials, however, shows the pernicious cumulative effect of additional reporting and citation biases, which together eliminated most negative... read more

Magnesium for Rapid Atrial Fibrillation Rate-Control in the ED

Magnesium for Rapid Atrial Fibrillation Rate-Control in the ED

Over the years, IV magnesium has been studied for the treatment of rapid AF in several clinical situations, most prominently in post-cardiac surgery patients. However, there are also studies in ED and cardiology patients,... read more