Tag: trial
A New Risk Assessment Model for Hospital-Acquired Venous Thromboembolism in Critically Ill Children
Using the multicenter Children’s Hospital-Acquired Thrombosis registry, we identified five independent risk factors for hospital-acquired venous thromboembolism in critically ill children, deriving a new hospital-acquired... read more
Saline vs. Balanced Crystalloid in Patients with Diabetic Ketoacidosis
In patients with diabetic ketoacidosis (DKA), the use of saline may be associated with longer time to DKA resolution, higher post-resuscitation serum chloride levels, lower post-resuscitation serum bicarbonate levels, and... read more
Effect of Early Fluvoxamine Treatment Among COVID-19 Patients
Treatment with fluvoxamine (100 mg twice daily for 10 days) among high-risk outpatients with early diagnosed COVID-19 reduced the need for hospitalisation defined as retention in a COVID-19 emergency setting or transfer to... read more
Bringing Biological ARDS Phenotypes to the Bedside with Machine-learning-based Classifiers
The identification of distinct phenotypes within heterogeneous disease states is a key component of personalised medicine, enabling enrichment of clinical trials, better prognostication, and delivery of tailored treatments... read more
The Small Percutaneous Catheter vs. Large Open Chest Tube For Traumatic Hemothorax
Small caliber 14-Fr PCs are equally as effective as 28- to 32-Fr chest tubes in their ability to drain traumatic HTX with no difference in complications. Patients reported better IPE scores with PCs over chest tubes,... read more
Anticoagulation in COVID-19
Thrombotic complications (arterial and venous) are common in patients admitted to hospital with COVID-19 and are an independent predictor of poor outcome. Microvascular thrombi also contribute to organ dysfunction, including... read more
Biomarker-guided Steroid Dosing in COVID-19 Pneumonia
Although corticosteroid administration has been associated with improved outcomes in severe COVID-19 pneumonia, their ideal use remains undefined with a "one size fits all" approach used, irrespective of the individual inflammatory... read more
Extracorporeal Cardiopulmonary Resuscitation (ECPR) in Adults
Rates of survival with functional recovery for both in-hospital and out-of-hospital cardiac arrest are notably low. Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a modality to improve prognosis by augmenting... read more
Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19
An overall good trial that supports the use of high flow oxygen therapy in patients with Severe COVID-19. Randomized controlled trial conducted across three centers in Columbia over 5 months from August 2020 to January... read more
Targeted Temperature Management in Adult Cardiac Arrest
Among adult patients with cardiac arrest, the use of targeted temperature management at 32–34 °C, when compared to normothermia, did not result in improved outcomes in this meta-analysis. There was no effect of initiating... read more
Loading and Increasing Vancomycin Dose Frequency Not Advantageous for Gram-Positive Sepsis in Infants
The efficacy of a vancomycin loading dose with more frequent dosing and shorter duration of treatment was comparable to standard dosing regimens for gram-positive sepsis in infants but with heightened risk for impaired hearing,... read more
Et Tu, Calcium?
We know our core medications for ACLS (epinephrine, amiodarone, lidocaine) but what is the role of other medications, like calcium? We know calcium can be used in the non-ACLS setting for hyperkalemia to prevent or treat... read more
Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest
Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial. The latter, although a small trial, showed improved neurologic outcomes at six months when patients... read more
High-dose vs. Low-dose Prednisolone in post-COVID-19 Patients
In some patients, respiratory symptoms and imaging abnormalities persist after acute coronavirus disease 2019 (COVID-19) pneumonia. The chest computed tomography (CT) generally shows diffuse parenchymal lung abnormalities... read more
Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis
The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia... read more
First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy
Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more
Lopinavir-ritonavir and Hydroxychloroquine for COVID-19 Patients
Recent trials involving steroids and other immunomodulators have shown benefits and contributed to improved care. Given the emerging nature of the virus, several repurposed agents were also considered as potential antiviral... read more
Severe Hyponatremia Management with DDAVP Clamp-Bolus Technique
The DDAVP clamp technique has considerably simplified the management of severe hyponatremia. The DDAVP clamp was a substantial step forwards in the management of severe hyponatremia. It eliminated a lot of the variability... read more
Safety and Efficacy of MUST-ARDS
This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more
Effectiveness of Therapeutic Heparin vs. Prophylactic Heparin on COVID-19 Patients
In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days... read more
Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest
Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more
Acute Eosinophilic Pneumonia Secondary to Daptomycin
Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after... read more
