Intermittent Hemodialysis for Managing Metabolic Acidosis During Resuscitation of Septic Shock

Intermittent Hemodialysis for Managing Metabolic Acidosis During Resuscitation of Septic Shock

Favorable changes in physiologic and biochemical variables and norepinephrine dependency were observed after IHD in patients with septic shock complicated by metabolic acidosis during resuscitation. Further studies are needed... read more

High Flow Nasal Cannula Benefits and Pitfalls

High Flow Nasal Cannula Benefits and Pitfalls

Emergency physicians should be familiar with the benefits and pitfalls of high-flow nasal cannula (HFNC). HFNC is well tolerated by patients, and its use contributes to superior outcomes for patients with pure hypoxemic... read more

Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe TBI

Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe TBI

In adults with severe traumatic brain injury (TBI), prehospital rapid sequence intubation by paramedics increases the rate of favorable neurologic outcome at 6 months compared with intubation in the hospital. A total of... read more

Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU

Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU

Pediatric acute respiratory distress syndrome (ARDS) contributes to a significant burden in the PICU of a developing country and is associated with significantly higher mortality. Infection remains the most common etiology.... read more

Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes

Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes

In this multicenter cohort, ventilation rates exceeding guidelines were common. Among the range of rates delivered, higher rates were associated with improved survival to hospital discharge. Arterial blood pressure and... read more

Mechanical Ventilation in Patients with Acute Ischemic Stroke

Mechanical Ventilation in Patients with Acute Ischemic Stroke

Although there are no specific data regarding the effect of respiratory management on stroke patients' outcomes, specific ventilator strategies in this population could potentially improve neurologic outcome and prevent respiratory... read more

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

In adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days. The number of ventilator-free... read more

High-Flow Nasal Cannula vs. Noninvasive Ventilation

High-Flow Nasal Cannula vs. Noninvasive Ventilation

High-flow conditioned oxygen therapy delivered through nasal cannulae and noninvasive mechanical ventilation (NIV) may reduce the need for reintubation. Therefore, Hernández et al set out to test if high-flow conditioned... read more

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure

Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation. Among 364 randomized... read more

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Ventilation

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Ventilation

This complex randomized, controlled trial failed to demonstrate that early extubation to non-invasive ventilation reduced the total time of mechanical ventilation. I will continue to extubate early and will use non-invasive... read more

Long-term Cognitive Impairment and Delirium in ICU

Long-term Cognitive Impairment and Delirium in ICU

ICU delirium was positively associated with impaired information processing speed and executive functioning at six-months post-discharge for this cohort. Testing for cognitive impairment with RBANS and TMT should be considered... read more

Echocardiographic Assessment of Pulmonary Artery Occlusion Pressure in Ventilated Patients

Echocardiographic Assessment of Pulmonary Artery Occlusion Pressure in Ventilated Patients

TEE accurately predicts invasive PAOP ≤ 18 mmHg in ventilated patients. This further increases its diagnostic value in patients with suspected acute lung injury/acute respiratory distress syndrome. During two consecutive... read more

Surviving Critical Illness: What Is Next?

Surviving Critical Illness: What Is Next?

This consensus-based framework for PT after hospital discharge aims to improve long-term outcomes for survivors of critical illness. Physical therapists should seek close collaboration with the multidisciplinary team... read more

Driving Pressure Is Associated with Outcome during Assisted Ventilation in ARDS

Driving Pressure Is Associated with Outcome during Assisted Ventilation in ARDS

In patients with Acute Respiratory Distress Syndrome (ARDS), plateau pressure, driving pressure, and respiratory system compliance can be measured during assisted ventilation, and both higher driving pressure and lower compliance... read more