Immediate Norepinephrine vs. Initial Fluid Loading
In endotoxemic shock, immediate start of norepinephrine significantly improved regional splanchnic and intestinal microcirculatory flows when compared with mandatory fixed-dose fluid loading preceding norepinephrine. Immediate... read more
Critical Care Sedation
This book provides a comprehensive guide to delivering analgesia and sedation to critically ill patients for professionals and caregivers being involved in the management of these patients. It discusses and explains in... read more
Infusion Management Software Can Seamlessly Connect Thousands Pumps Across Facilities
A newly-launched next-generation infusion management platform provides organizations with a blend of real-time views and retrospective reporting capabilities, enhancing the understanding of their infusion pump fleet and associated... read more
High Speed Blood Flow Measurements Enabled by LW-iDCS
In this work we have demonstrated the development of long wavelength, interferometric diffuse correlation spectroscopy. Using a fiber optic probe with collocated detection fibers, we were able to directly compare measured... read more
Rapid Sepsis Tests Using Magnetic Nanoparticles
Qun Ren, an Empa researcher, and her team are currently developing a diagnostic procedure that can rapidly detect life-threatening blood poisoning caused by staphylococcus bacteria. Staphylococcal sepsis is fatal in up... read more
TEE Before Cardioversion in Atrial Fibrillation Patients
Transesophageal echocardiography (TEE) offers an invaluable, non-invasive avenue for diagnosing and managing various cardiac conditions, including atrial fibrillation (AF). As the most common cardiac arrhythmia, AF affects... read more
Esophageal Adenocarcinoma Causing Nonbacterial Thrombotic Endocarditis
Nonbacterial thrombotic endocarditis (NBTE) is a rare condition that causes noninfectious vegetative lesions of heart valves. NBTE is generally seen in association with advanced malignancy. The patient in this case is a 54-year-old... read more
Oxford Textbook of Critical Care
The thoroughly revised 2nd edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely the book takes a problem-orientated approach... read more
Rescue TEE Might Diagnose Cardiac Arrest Faster
A Penn Medicine team is testing whether a new technology that gives live ultrasound images from inside a patient during CPR can help doctors get those answers faster. The device, called Rescue TEE, uses a tiny camera at the... read more
Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm
A recent study found that secondary bacterial pneumonia, rather than the much-discussed “cytokine storm,” is a significant factor in COVID-19-related fatalities. Almost half of the patients who required mechanical... read more
Iatrogenic Hypoxemia and Atrial Septal Defect Due to Electrical Storm Ablation After Left Ventricular Assist Device
Predominant strategies for the management of electrical storm include antiarrhythmic medical therapy, beta-blockers, and catheter ablation. Some studies have demonstrated refractory electrical storm managed with mechanical... read more
Deep Learning-based Electrocardiographic Screening for Chronic Kidney Disease
Undiagnosed chronic kidney disease (CKD) is a common and usually asymptomatic disorder that causes a high burden of morbidity and early mortality worldwide. We developed a deep learning model for CKD screening from routinely... read more
Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients
Whether prone positioning of patients undergoing mechanical ventilation for COVID-19 pneumonia has benefits over supine positioning is not clear. We conducted a systematic review with meta-analysis to determine whether prone... read more
Traumatic Hemorrhage and Chain of Survival
Trauma is the number one cause of death among Americans between the ages of 1 and 46 years, costing more than $670 billion a year. Following death related to central nervous system injury, hemorrhage accounts for the majority... read more
Patients With PAH Face Unique Considerations for Lung Transplantation
Insights from a new paper outline the unique considerations and management approaches for patients with pulmonary arterial hypertension (PAH) undergoing lung transplantation. Currently approved treatment options for Group... read more
Coronary Sinus Value During CTPA for Predicting Pulmonary Hypertension in Patients with Acute Pulmonary Embolism
The coronary sinus ostium area (CSOA) and coronary sinus ostium diameter (CSOD) demonstrated a good ability to predict PH. However, the CSOA exhibited a better performance for predicting development of PASP >30 mmHg. CSOA... read more
The ICU Book
A fundamental and respected resource book in critical care, The ICU Book, continues to provide the current and practical guidance that have made it the best-selling text in critical care. The text addresses both the medical... read more
Significant Persistent Pain Symptoms After Critical Care Illness
Persistent pain could be a common health problem after critical illness care. Our data also suggest that there is a lack of specific follow-up after ICU discharge. Given the major consequences on patient quality of life,... read more
Diagnostic Accuracy of Point-of-Care Ultrasound for Shock
In this study, the identification of the etiology of shock by Point-of-Care Ultrasound (POCUS) was characterized by high sensitivity and a positive likelihood ratio, especially for obstructive shock. Hence, these findings... read more
Thrombotic and Bleeding Complications During Antithrombotic Treatment
Remarkable progress has been made in the pharmacological management of patients with cardiovascular disease, including the frequent use of antithrombotic agents. Nonetheless, bleeding complications remain frequent and potentially... read more
Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients
n this randomized clinical trial of critically ill participants hospitalized for COVID-19, treatment with a P2Y12 inhibitor did not improve the number of days alive and free of cardiovascular or respiratory organ support.... read more
Acute Traumatic Coma Awakening by Right Median Nerve Electrical Stimulation
Severe traumatic brain injury (TBI) leads to acute coma and may result in prolonged disorder of consciousness (pDOC). We aimed to determine whether right median nerve electrical stimulation is a safe and effective treatment... read more
