Barotrauma Rate Is 25% in ARDS Patients Receiving ECMO
Patients with acute respiratory distress syndrome (ARDS) receiving mechanical ventilation have a high risk of barotrauma, which often has poor prognosis and high mortality. Although ECMO should theoretically protect patients... read more
Resuscitative TEE
The use of ED resuscitative transesophageal echocardiography (TEE) is a practical modality that provides useful diagnostic and therapeutic information for critically ill patients in the emergency department, with an excellent... read more
Acute Respiratory Distress Syndrome
This book covers all clinical aspects of acute respiratory distress syndrome (ARDS), from definition to treatment, focusing on the more recent recommendations and evidence-based medicine. The addressed topics are the... read more
Temporal Trends in the Use of Computed Tomographic Pulmonary Angiography for Suspected Pulmonary Embolism
Despite the recent validation of clinical decision rules to limit the use of computed tomographic pulmonary angiography (CTPA), an increase in the CTPA rate along with more diagnosed pulmonary embolism (PE) and especially... read more
Environmental Impact of Single‑use and Reusable Items in CVC-insertion Kits
he use of CVC-insertion kits containing reusable metal instruments and reusable textiles offer a robust opportunity to reduce the environmental impacts and financial costs of CVC insertions in a European setting, compared... read more
Validation of qSOFA as a Screening Tool for Early Identification of Sepsis Patients
Sepsis and septic shock are major healthcare problems, affecting millions of people around the world each year. The speed and appropriateness of therapy administered in the initial hours of treatment are likely to influence... read more
Cardiovascular Subphenotypes in ARDS
Latent class analysis (LCA) of transthoracic echocardiography (TTE) parameters identified four cardiovascular subphenotypes in acute respiratory distress syndrome (ARDS) that more closely aligned with circulatory failure... read more
Acute Respiratory Distress Syndrome: Advances in Diagnostic Tools and Disease Management
Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease.... read more
Atrial Fibrillation and Ischemic Stroke Patients While on Oral Anticoagulation
Patients with Atrial Fibrillation (AF) and ischemic stroke while on oral anticoagulation are at increased risk of recurrent ischemic stroke and death. These patients currently have an unmet medical need. Individual participant... read more
The Ketamine Drive-Through
Patients who present with unexplained urinary tract symptoms or laboratory abnormalities on tests for liver injury should be asked about exposure to ketamine. Patients who chronically use ketamine should also be screened... read more
Half of Healthcare Workers with COVID-19 Showed Up For Work
About 50% of healthcare workers with symptomatic COVID-19 showed up for work, indicating concern over high workload burden for coworkers and personal responsibility. The findings were published in Infection Control & Hospital... read more
Acute Ischemic Stroke: Recent Advances in Reperfusion Treatment
Stroke is a major clinical challenge. The authors note that during the last 5–7 years, tremendous progress was achieved in the reperfusion treatment of acute ischemic stroke during its first few hours from symptom onset.... read more
Duration of Device-Based Fever Prevention After Cardiac Arrest
While fever prevention for 72 hours after cardiac arrest has been endorsed by international guidelines since 2005, there is a lack of randomized control trial (RCT) generated data supporting this after the initial 24 hours... read more
Heparin-induced Thrombocytopenia in the Intensive Care Setting
Heparin-induced thrombocytopenia (HIT) is a serious iatrogenic complication of heparin treatments. The diagnosis of HIT is difficult in the intensive care setting because thrombocytopenia is a frequent and multifactorial... read more
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19
Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding... read more
Combination Treatment of Persistent COVID-19 in Immunocompromised Patients
Little data exists to guide the treatment of persistent COVID-19 in immunocompromised patients. We have employed a unique protocol combining tixegavimab/cilgavimab, and short-term combination antivirals including remdesivir.... read more
Differential Diagnosis and Cause-specific Treatment During OHCA
The cardiopulmonary resuscitation (CPR) guidelines recommend identifying and correcting the underlying reversible causes of out-of-hospital cardiac arrest (OHCA). However, it is uncertain how often these causes can be... read more
Family Centered Care At The EOL in the ICU
In the context of end-of-life (EOL) care in the intensive care unit (ICU), recent research has often focussed on patients' families. Studies have shown the importance of communication between ICU clinicians and families,... read more
Biggest AMR dilemma: to give, or not to give antibiotics?
Sepsis (a dysregulated reaction of the body to infection with 50 million cases per year) must be treated with antibiotics as soon as it is suspected — ideally, within the first hour. Antibiotics are thus easily administered... read more
Predicting Deterioration of Sepsis Patients Using Continuous HVR Analysis
We showed that continuous electrocardiograms (ECG) recordings can be automatically analyzed and used to extract heart rate variability (HRV) features associated with clinical deterioration in sepsis. The predictive accuracy... read more
Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania
The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments in the United States about two confirmed outbreaks of Marburg... read more
Are Two Shocks Better Than One?
Overall, the trial conducted by Cheskes et al contributes meaningfully to our understanding of the use of alternative defibrillation strategies for refractory ventricular fibrillation before widespread incorporation of double... read more
