A Rational Approach on the use of ECMO in Severe Hypoxemia

Veno-venous extracorporeal membrane oxygenation (ECMO) is a helpful intervention in patients with severe refractory hypoxemia either because mechanical ventilation cannot ensure adequate oxygenation or because lung protective... read more

Psychological burden in patients with COVID-19 and their relatives 90 days after hospitalization

COVID-19 is linked to clinically relevant psychological distress in a subgroup of patients and their relatives 90 days after hospitalization. If confirmed in an independent and larger patient cohort, knowledge about these... read more

Moderna Vaccine 94.1% Efficacy Preventing Symptomatic COVID-19

The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants... read more

COVID-19 Surges Increased Patient Mortality

A recent study by scientists at the National Institutes of Health suggests that one in every four COVID-19 deaths in the United States may be attributed to hospitals strained by surging caseloads. Published in the Annals... read more

Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization

The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes... read more

New Device for Intubation Through a Laryngeal Mask Airway

On review of the literature, it is abundantly obvious that an endotracheal tube (ETT) with a posterior-facing bevel and curved or tapered tip to center the tube on the scope and reduce hang-up is ideal for intubation over... read more

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient. Continuous... read more

Thrombosis vs. Hemorrhage Rates in Patients with Severe Respiratory Failure Due to COVID-19

Significant rates of pulmonary thromboembolism and of catheter-associated deep vein thrombosis were seen in both viral infections but were greater in those requiring the use of extracorporeal membrane oxygenation in coronavirus... read more

Is Daily Enoxaparin Dosing As Good As Twice Daily?

Venous thromboembolism (VTE) remains a big problem for trauma professionals and the patients they take care of. Every trauma center has some sort of VTE prophylaxis protocol for stratifying risk, prescribing mechanical... read more

Clinical Trials Design Evaluating Sedation in Critically Ill Adults Requiring Mechanical Ventilation

These recommendations are intended to assist researchers in the design, conduct, selection of endpoints, and reporting of clinical trials involving sedative medications and/or sedation protocols for adult ICU patients who... read more

Single-use Endoscopy

Endoscopy is used in a variety of medical specialties ranging from gastroenterology to urology, cardiology and critical care. Traditionally, health systems have invested in reusable endoscopy equipment, but an industrywide... read more

Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations

In uncontrolled, moderate-to-severe asthma, higher baseline FeNO levels were associated with greater risk of severe asthma exacerbations, particularly in combination with elevated eosinophil count and prior exacerbations,... read more

Melatonin for Delirium Prevention in Hospitalized Patients

Melatonin/ramelteon are associated with reduction in delirium incidence in hospitalized patients. However, this effect seems confined to surgical and ICU patients. The optimum dosage and formulation of melatonin, and... read more

Preoperative vena cava filter placement in recurrent cerebral fat embolism following traumatic multiple fractures

Despite scarce evidence, we reckon that Inferior Vena Cava Filter (IVCF) could improve prognosis in selected patients with fat embolism syndrome (FES), especially those presenting high risk factors, after accurately weighing... read more

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe... read more

REGN monoclonal antibodies work in selected hospitalised COVID-19 patients

New findings suggest a significant benefit from REGN in terms of the primary outcome of mortality for patients who have low levels of their own antibodies at the time of admission. This was an unexpected result for me... read more

Multimorbidity on Long-Term Outcomes Following ICU Discharge

This national cohort study has demonstrated increased resource use for critical care survivors in the year following discharge but fails to replicate past findings of increased longer-term mortality. Multimorbidity, lifestyle... read more

Percutaneous Dilational Tracheostomy for COVID-19 Patients Requiring Mechanical Ventilation

Patients with COVID-19 who survive the early days of MV experience severe and prolonged respiratory failure. An early modified percutaneous dilational tracheostomy (PDT) was safe for patients and healthcare providers and... read more

Dealing with missing delirium assessments in prospective clinical studies of the critically ill

For longitudinal data where a summary exposure is of interest, we recommend practitioners adopting the passive imputation strategy. Simulations show that all methods performed comparably when the proportion of missingness... read more

Laryngeal Radiation Fibrosis: A Case of Failed Awake Flexible Fibreoptic Intubation

In patients with severe upper airway narrowing because of radiation fibrosis, an awake fibreoptic intubation may be impossible and a tracheotomy is the only means of securing this airway; however, there may be no evident... read more

Virtual Handover of Patients in the PICU During the COVID-19 Crisis

Video-conferencing applications for online handovers could supplement traditional face-to-face intensive care unit patient handover during outbreaks of infectious diseases. The use of video streaming and more emphasis on... read more

RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more