Targeting MAP in Sepsis

What’s your target mean arterial pressure (MAP) for patients with sepsis? Do you believe in the magic number of 65? What about those patients with chronic hypertension? What about when there is no evidence of end organ... read more

Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19

Delirium without coma occurred in 29.1% of patients admitted to the ICU. Delirium persisted for a median of 5 days and was severe. Mechanical ventilation was significantly associated with odds of delirium even after adjustment... read more

Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in ARDS Patients During VV-ECMO

Intracranial hemorrhage occurs early during venovenous extracorporeal membrane oxygenation (VV-ECMO) and is a determinant for 60-day mortality. Appropriate adjustment of identified modifiable risk factors might lower... read more

Effectiveness of Bundle Interventions on ICU Delirium

This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more

Perspectives of Ketamine Use in COVID-19 Patients

Hospitalized coronavirus disease 2019 (COVID-19)-infected patients suffer from both physical impairments and mental stress. Respiratory insufficiency and cardiovascular disturbances require most of the intensive care... read more

Mortality of Older Patients Admitted to an ICU

In this systematic review of older patients admitted to intensive care, we have documented substantial variation in short- and long-term mortality as well as in prognostic factors evaluated. To better understand this... read more

Let’s stop the blame game over the ICU beds shortage for COVID-19 patients

The situation in UK intensive care units (ICUs) is grave. Across the UK, units are under immense pressure and are as busy or busier than they were in the first wave. All plans enacted over the summer to provide support for... read more

Allergic Reactions After First Dose of Pfizer-BioNTech COVID-19 Vaccine

Anaphylactic reactions to the first dose of the Pfizer-BioNTech COVID-19 vaccine are rare, usually occur within 30 minutes of administration, and are readily treatable. From December 14-23, 2020, following administration... read more

High-dose Vitamin C in Critically Ill COVID-19 Patients

This pilot trial showed that high-dose intravenous vitamin C (HDIVC) failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even... read more

Barriers to reporting guideline adherence in POCUS research

Although investigators and editors recognise the importance of completely reported research, reporting quality is still a core issue for point-of-care ultrasound (POCUS) research. The shared opinion held by investigators... read more

Subtle Presentations of Shock in the ED Setting

The patient was a 2-year-old female with a history of allergy to peanuts who was brought to the emergency department by her mother because of a complaint of allergic reaction. Twenty minutes prior to arrival, the patient... read more

Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients

The Montreal Heart Institute announced COLCORONA clinical trial has provided clinically persuasive results of colchicine's efficacy to treat COVID-19. The study results show that colchicine reduces the risk of death or... read more

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

In a small sample, prone positioning non-intubated COVID-19 patients with severe hypoxemia was safe; however, many patients did not tolerate prolonged durations. Although patients had improved oxygenation and respiratory... read more

Full-dose blood thinners decreased need for life support and improved outcomes in COVID-19 patients

Full dose anticoagulation (blood thinner) treatments given to patients hospitalized for COVID-19 reduced the requirement of vital organ support in a large clinical trial conducted worldwide. With large numbers of COVID-19... read more

RAPID UPDATE: Clinical Guide for the Management of Critical Care for Adults with COVID-19

This RAPID UPDATE to the FICM/ICS "Clinical guide for the management of critical care for adults with COVID-19 during the Coronavirus pandemic" highlights five clinically urgent issues for practising clinicians caring for... read more

Tocilizumorelikeit? The latest data on Tocilizumab

Our hats were then blown away when the REMAP-CAP team and the UK government fired an evidence-based carpet bomb in our direction. We saw a trial press release, a preprint article, an alert letter from the MHRA/DHSC, national... read more

Antimicrobial‑associated Harm in Critical Care

The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antimicrobial... read more

ICU Strain and Mortality Risk Among Critically Ill Patients with COVID-19

The coronavirus disease 2019 (COVID-19) pandemic has affected numerous communities, and reports of overburdened hospitals, specifically critical care units, have become commonplace. High-quality supportive care remains the... read more

De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19

This case series concludes that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and that survival with concomitant renal failure is rare. This is a case series of patients... read more

Harnessing a Pioneering Cell Therapy Treatment for COVID-19 Patients with ARF

A world-leading UK-wide trial supported by NIHR is offering a pioneering cell therapy treatment for patients with acute respiratory failure (ARF) caused by COVID-19. The groundbreaking study, led by experts at Queen's... read more

Overcoming Enteral Nutrition Delivery Challenges in Critical Care

It is the essential implementation of this new evidence occurs to overcome real and perceived EN challenges. This data should lead to increased standardization/protocolization of ICU nutrition therapy to ensure personalized... read more

Adjuvant therapeutic plasma exchange in septic shock

The hallmark of sepsis is a pathological host response to an infection that may lead to organ dysfunction, shock and high mortality. Besides numerous circulating mediators initiating inflammation, vascular barrier breakdown... read more