Presenting Characteristics Associated With Outcome in Children With Severe TBI

Severe traumatic brain injury is a clinically heterogeneous disease that can be accompanied by a range of neurologic impairment and a variety of injury patterns at presentation. This secondary analysis of prospectively collected... read more

Presenting Characteristics Associated With Outcome in Children With Severe TBI

Oxygen Therapy for Acutely Ill Medical Patients

It is a longstanding cultural norm to provide supplemental oxygen to sick patients regardless of their blood oxygen saturation. A recent systematic review and meta-analysis has shown that too much supplemental oxygen increases... read more

Oxygen Therapy for Acutely Ill Medical Patients

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe TBI

Among patients with severe traumatic brain injury (TBI), early prophylactic hypothermia compared with normothermia did not improve neurologic outcomes at 6 months. These findings do not support the use of early prophylactic... read more

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe TBI

Stronger evidence for vitamin C use in sepsis treatment

A new meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favorable patient outcomes. Results of the meta-analysis showed a marked reduction in mortality and duration... read more

Stronger evidence for vitamin C use in sepsis treatment

ICU Care Improved with Conflict Management Education

Stressful by nature, the intensive care unit (ICU) inevitably faces conflicts due to immediate and cohesive action from physicians, nurses, respiratory therapists, and advanced practitioners. In an effort to help improve... read more

ICU Care Improved with Conflict Management Education

How Do Resuscitation Teams at Top-Performing Hospitals for In-Hospital Cardiac Arrest Succeed?

Resuscitation teams at hospitals with high IHCA survival differ from non–top-performing hospitals. Our findings suggest core elements of successful resuscitation teams that are associated with better outcomes and form the... read more

How Do Resuscitation Teams at Top-Performing Hospitals for In-Hospital Cardiac Arrest Succeed?

Prone Positioning for a Morbidly Obese Patient with ARDS

Since the description in the 1970s of external positive end-expiratory pressure for acute respiratory distress syndrome (ARDS), the optimum level of external positive end-expiratory pressure remains unresolved. In the 1990s,... read more

Prone Positioning for a Morbidly Obese Patient with ARDS

Do Nurse Staffing Ratios Work? New Research Says No

Advocates of mandated staffing ratios say they improve patient outcomes. A recent study finds otherwise. Nurse-to-patient ratios are a hot button issue. Look no further than Massachusetts for an example. After a battle that... read more

Do Nurse Staffing Ratios Work? New Research Says No

Sepsis Around the Cradle of Humankind

While representing the cutting edge of civilization everywhere, mothers and their newborn infants are a population particularly vulnerable to sepsis.1 By recognizing the importance of antiseptic prophylaxis (handwashing),... read more

Sepsis Around the Cradle of Humankind

Trends in Visits to Acute Care Venues for Treatment of Low-Acuity Conditions

From 2008 to 2015, total acute care utilization for the treatment of low-acuity conditions and associated spending per member in the United States increased, and utilization of non-ED acute care venues increased rapidly.... read more

Trends in Visits to Acute Care Venues for Treatment of Low-Acuity Conditions

Identifying Distinct Subgroups of ICU Patients: A Machine Learning Approach

Identifying subgroups of ICU patients with similar clinical needs and trajectories may provide a framework for more efficient ICU care through the design of care platforms tailored around patients' shared needs. However,... read more

Identifying Distinct Subgroups of ICU Patients: A Machine Learning Approach

Gender Disparities Among Adult Recipients of Bystander CPR in the Public

Males had an increased likelihood of receiving Bystander Cardiopulmonary Resuscitation (BCPR) compared with females in public. BCPR improved survival to discharge, with greater survival among males compared with females.... read more

Gender Disparities Among Adult Recipients of Bystander CPR in the Public

Early Versus Late Initiation of Renal Replacement Therapy in Critically Ill Patients

Early initiation of renal replacement therapy (RRT) effect on survival and renal recovery of critically ill patients is still uncertain. We aimed to systematically review current evidence comparing outcomes of early versus... read more

Early Versus Late Initiation of Renal Replacement Therapy in Critically Ill Patients

Perspectives on Strained ICU Capacity: A Survey of Critical Care Professionals

Strained intensive care unit (ICU) capacity represents a supply-demand mismatch in ICU care. Limited data have explored health care worker (HCW) perceptions of strain. Strained capacity is perceived as common among inter-professional... read more

Perspectives on Strained ICU Capacity: A Survey of Critical Care Professionals

Predicting the Requirement for RRT in Intensive Care Patients with Sepsis

Sepsis is one of the most frequent causes of acute kidney injury (AKI) in critically ill patients, with initial organ impairment often followed by dysfunction in other systems. Renal dysfunction may therefore represent one... read more

Predicting the Requirement for RRT in Intensive Care Patients with Sepsis

Hemodynamic Tolerance to IV Clonidine Infusion in the PICU

Although administration of clonidine is often associated with bradycardia and hypotension, these complications do not seem clinically significant in a mixed PICU population with a high degree of disease severity. Clonidine... read more

Hemodynamic Tolerance to IV Clonidine Infusion in the PICU

Increased Early Systemic Inflammation in ICU-Acquired Weakness

The main objective is to investigate whether patients who develop ICU-acquired weakness have a different pattern of systemic inflammatory markers compared with critically ill patients who do not develop ICU-acquired weakness.... read more

Increased Early Systemic Inflammation in ICU-Acquired Weakness