Impacts of Initial ICU Driving Pressure on Outcomes in Acute Hypoxemic Respiratory Failure

Driving pressure (DP) is a marker of severity of lung injury in patients with acute respiratory distress syndrome (ARDS) and has a strong association with outcome. However, it is uncertain whether limiting DP can reduce... read more

Extended Prone Position and 90-Day Mortality in Mechanically Ventilated Patients with COVID-19

Extended prone positioning (PP) was associated with improved 90-d survival in subjects with COVID-19 undergoing mechanical ventilation for severe ARDS. These findings suggest the potential benefit of EPP in the management... read more

The Pathophysiology of Happy Hypoxemia in COVID-19

The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional... read more

ARDS and Prone Positioning

Prone positioning has been a treatment option for acute respiratory distress syndrome in critically ill patients. Since the COVID-19 pandemic, awake prone positioning has been utilized as a treatment option for non-intubated... read more

Adjusting risk of AKI for Time on Controlled Mechanical Ventilation in ARDS

The authors expressed concerns that the study did not account for certain key covariates, such as septic shock, right heart failure, or hypoxemia, which are believed to influence the development of AKI. We would like... read more

Plasma Bioactive Adrenomedullin Predicts Mortality and Need for Dialysis in Critical COVID-19

In this study, serial bio-ADM samples in the ICU had limited predictive power for mortality in critically ill COVID-19 patients when looking at absolute values. Still, relative changes over time showed a much better prediction.... read more

VAP Prevention in the ICU

Critically ill patients admitted to an intensive care unit for a life-threatening condition (both medical and surgical) can contract a ventilator-associated pneumonia (VAP). This is an infection acquired by virtue of... read more

Aspirin Reduces the Need for Mechanical Ventilation by Nearly Half For COVID-19 Patients

Patients hospitalized with COVID-19 and taking aspirin were nearly half as likely to require mechanical ventilation as those with COVID-19 not taking the drug, according to a study of adult patients. The patients were... read more

Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early... read more

Outcomes of ECMO in ARDS in Pediatric Trauma Patients

Among children who suffer from acute respiratory distress syndrome (ARDS) complications following trauma, the use of extracorporeal membrane oxygenation (ECMO) failed to show any association with mortality benefit. More... read more

Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS

The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more

Low-Frequency Ventilation May Facilitate Weaning in ARDS Treated with ECMO

Low-frequency ventilation is comparable to conventional protective ventilation in patients with ARDS who have been treated with ECMO. However, low-frequency ventilation may support weaning from invasive mechanical ventilation... read more

A prediction model for nonresponsive outcomes in critically ill patients with ARDS undergoing prone position ventilation

In this study, a risk prediction model for nonresponse to prone position ventilation in acute respiratory distress syndrome (ARDS) patients was constructed, which demonstrated good predictive value and clinical utility. Early... read more

Predictors of High-flow Nasal Cannula Failure in COVID-19 Patients

A retrospective cohort study was conducted during the months of March and May 2021. Data collection was based on a follow-up of 156 hospitalized patients with a diagnosis of COVID-19 who were users of high-flow nasal cannula... read more

How does high fowlers position help with ventilation?

The High Fowler's position, characterized by an inclination of 60-90 degrees, significantly enhances ventilation by optimizing lung expansion and improving respiratory mechanics. This position is particularly beneficial for... read more

COVID-19 ARDS Patients vs. Patients with ARDS

Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS... read more

Early Reapplication of Prone Position During VV-ECMO for ARDS

A combination of prone positioning (PP) and venovenous extracorporeal membrane oxygenation (VV-ECMO) is safe, feasible, and associated with potentially improved survival for severe acute respiratory distress syndrome (ARDS).... read more