Tag: biomarkers
Do We Need New Trials of Procalcitonin-Guided Antibiotic Therapy?
Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect... read more
The EM Educator Series: Sepsis in the ED
These posts provide brief mini-cases followed by key questions to consider while working. The featured questions provide important learning points for those working with you, as well as vital items to consider in the evaluation... read more
Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic AKI
In septic acute kidney injury (AKI), renal medullary and urinary hypoxia developed several hours before increases in currently used biomarkers. Angiotensin II transiently improved renal function without worsening medullary... read more
High Morning Cortisol Tied to Long-term Anxiety in Family Members of ICU Patients
A new study published in the journal Critical Care Medicine finds that a biomarker may help identify which family members will be most emotionally impacted by their loved one's ICU stay. In particular, family members who... read more
Are Biomarkers Ready for Prime Time?
Kyle Enfield, MD, speaks with John A. Kellum, MD, MCCM, about his talk presented at the 46th Critical Care Congress in Honolulu, Hawaii entitled, "Are Biomarkers Ready for Prime Time?" Dr. Kellum works as an Intensivist in... read more
Updates on Sepsis from WSC
Fourth session from the World Sepsis Congress Spotlight: Maternal and Neonatal Sepsis - Updates on Sepsis.... read more
Platelets and Multi-Organ Failure in Sepsis
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more... read more
Translational Evidence for Two Distinct Patterns of Neuroaxonal Injury in Sepsis
Ischemic and diffuse neuroaxonal injury to the brain in experimental sepsis, human postmortem brains, and in vivo MRI suggest these two distinct lesion types to be relevant. Future studies should be focused on body fluid... read more
Biomarkers in AKI: That’s All the Story?
We would like to add to the recent editorial by McMahon on biomarkers of acute kidney injury (AKI), with a specific focus on biomarkers in the clinical setting of cardiac surgery-associated AKI (CSA-AKI). We agree with McMahon... read more
External validation of a biomarker and clinical prediction model for hospital mortality in ARDS
Mortality prediction in ARDS is important for prognostication and risk stratification. However, no prediction models have been independently validated. We validated a mortality prediction model for ARDS that includes age,... read more
In Treating Sepsis, Questions About Timing and Mandates
The question of whether Rory's Regulations save lives isn’t asked or answered in the recent study. Sepsis deaths were already decreasing in the United States before the mandate, and determining its contribution to... read more
Heart Rate Variability in Critical Care Medicine
Heart rate variability (HRV) has been used to assess cardiac autonomic activity in critically ill patients, driven by translational and biomarker research agendas. Several clinical and technical factors can interfere with... read more
Sepsis Prediction in Critically Ill Patients by Platelet Activation Markers on ICU Admission
Platelets have been involved in both immune surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to sepsis in critical... read more
Drink Coffee and Live Longer: Cohort Study
A multinational cohort study on coffee drinking and mortality in 10 European countries. Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country. 521, 330 people... read more
New Biomarker Improves Early Sepsis Detection in the Emergency Department
Sepsis most often presents to the emergency department (ED), and delayed detection is harmful. The white blood count (WBC) is often used to detect sepsis in the ED. New research shows that volume increases of circulating... read more
Generalizable Biomarkers in Critical Care
The sequencing of the human genome and the subsequent availability of inexpensive, robust methods for "omics" profiling (e.g., genome-wide association studies, gene expression microarrays, and metabolomics) have... read more
NIH Consortium to Study Biomarkers for Dementia
A new National Institutes of Health (NIH) funded consortium will work to identify and validate trial-ready biomarkers for small vessel diseases in the brain that contribute to cognitive impairment and dementia. Seven participating... read more
Adrenomedullin: a marker of impaired hemodynamics in cardiogenic shock
Bio-ADM is a valuable prognosticator and marker of impaired hemodynamics in CS patients. High levels of bio-ADM may show shock refractoriness and developing end-organ dysfunction and thus help to guide therapeutic approach... read more
Serum biomarker associated with metformin dosing or use
The growth differentiation factor 15 (GDF15) is a novel biomarker for the use and dosing of metformin, according to a study published online Dec. 14 in Diabetes Care. 237 serum biomarkers from participants in the Outcome... read more
Fatty Acid Levels Could Help Predict Psychosis Risk
A novel probabilistic model that combines history, clinical assessment, and fatty-acid biomarkers could help predict transition to first-episode psychosis.... read more
New Research Shows NEPHROCHECK Test Predicts Acute Kidney Injury Risk For Transaortic Valve Implant Patients
Astute Medical, Inc., developer of biomarkers for better healthcare, today said that newly published findings show that the Company's NEPHROCHECK Test may help physicians identify risk of a serious complication in patients... read more
