Tag: biomarkers
Intravenous Fluid Therapy in Critically Ill Adults
Despite the administration of intravenous fluids to critically ill patients being a near-universal intervention, the available evidence base guiding their safe and appropriate use is scarce and derived mainly from academically... read more
Correlation Among Endothelial Injury, Organ Dysfunction, and Several Biomarkers in Sepsis Patients
Protein C was superior for the prediction of organ dysfunction after 7 days of ICU treatment when compared with other biomarkers of endothelial function, inflammation, and coagulation. C-reactive protein (CRP) and white blood... read more
Abnormalities in the Host Immune Response During Hospitalization for Sepsis
In this cohort study of 483 patients who survived hospitalization with sepsis at 12 US hospitals, 25.8% had elevated high-sensitivity C-reactive protein levels (a marker of inflammation) at 3 months, 30.2% at 6 months, and... read more
Assessment of immune organ dysfunction in critical illness
Critical illness may often induce persisting injury-associated immunosuppression with adverse effects on relevant patient-centered outcomes. However, despite the key task of ICU physicians to detect, monitor, and follow up... read more
Biomarkers and Clinical Scores to Identify Patient Populations at Risk of Delayed Antibiotic Administration or Intensive Care Admission
Patients with low severity signs of infection but high MR-proADM concentrations had an increased likelihood of subsequent disease progression, delayed antibiotic administration or ICU admission. Appropriate triage decisions... read more
Vitamin C for Sepsis
Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just... read more
Effect of Vitamin C Infusion on Organ Failure in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and Acute Respiratory Distress Syndrome (ARDS), a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers... read more
Comparison of Diagnostic Accuracy Among Procalcitonin, C-reactive protein, and Interleukin 6 for Blood Culture Positivity in General ICU Patients
Despite various technological advances, it still usually takes at least 24 to 48 h to obtain a blood culture result. The subsequent delays in diagnosis and treatment of infection can negatively impact care in the intensive... read more
Derivation and Validation of Plasma Endostatin for Predicting Renal Recovery from AKI
Plasma endostatin shows a useful value for predicting failure to recover from acute kidney injury (AKI). The predictive ability can be greatly improved when endostatin is combined with the Sequential Organ Failure Assessment... read more
Phenotyping: Need to Identify Subgroups of ARDS Patients
The consensus definitions of acute respiratory distress syndrome (ARDS) mainly rely on feasible clinical criteria, which help to group patients together for inclusion in clinical trials and for clinical management. This generates... read more
Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis
Combined biomarkers predict risk for 14-day and total mortality among subjects with suspected sepsis. Serum amyloid P and tissue plasminogen activator demonstrated the best discriminatory ability in this cohort. Fourteen-day... read more
Immunotherapy Effects on Sepsis
A randomised controlled multicentre trial assessed for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 (anti–PD-L1) immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb,... read more
Neutrophil Extracellular Traps Are Elevated in Patients with Pneumonia-related ARDS
Bronchoalveolar neutrophil extracellular trap concentration was not significantly associated with mechanical ventilation duration in pneumonia-related ARDS. The acute respiratory distress syndrome (ARDS) is the most severe... read more
New Guidelines for Hospital-acquired Pneumonia/Ventilator-associated Pneumonia
American and European guidelines have many areas of common agreement such as limiting antibiotic duration. Both guidelines were in favor of a close clinical assessment. Neither recommended a regular use of biomarkers but... read more
