Tag: biomarkers
Surfactant protein D is a causal risk factor for COPD
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive... read more
The utility of biomarkers in traumatic brain injury clinical management
Currently, TBI management is guided by clinical histories and neuroimaging techniques. While these techniques may be advanced, they are more costly than serum analysis, involve exposure to ionizing radiations, and have certain... read more
Metabolic-based Biomarkers Have Potential to Triage Children with Sepsis
A new study has validated potential biomarkers for a sepsis-triage model to distinguish sepsis patients requiring care in the pediatric intensive care unit (PICU) from sepsis identified in the pediatric emergency department... read more
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical ICU patients
Aged, critically ill surgical patients have greater organ dysfunction and incidence of adverse clinical outcomes after sepsis. Biomarker profiles suggest an immunophenotype of persistent immunosuppression and catabolism.... read more
Blood test may obviate need for head CTs in brain trauma evaluation
A biomarker test based on the presence of two proteins in the blood appears to be suitable for ruling out significant intracranial injuries in patients with a history of mild traumatic brain injury (TBI) without the need... read more
Early PREdiction of Sepsis Using Leukocyte Surface Biomarkers
From a large panel of leukocyte biomarkers, immunosuppression biomarkers were associated with subsequent sepsis in ED patients with suspected acute infection. Between January 2014 and February 2016, we recruited 272, 59 and... read more
Viral Sepsis in Children
Sepsis in children is typically presumed to be bacterial in origin until proven otherwise, but frequently bacterial cultures ultimately return negative. Although the incidence of viral-induced sepsis is not precisely known,... read more
Circulating Biomarkers May be Unable to Detect Infection at the Early Phase of Sepsis in ICU Patients
During the study period, 363 patients with SIRS were screened, 84 having exclusion criteria. Ninety‑one patients were classified as having non‑septic SIRS and 188 as having sepsis. Eight biomarkers had an area under... read more
Temporal Biomarker Profiles and Their Association with ICU Acquired Delirium
While there are differences in markers (adiponectin and several brain proteins) between patients with and without delirium, the development of delirium is not preceded by a change in the biomarker profile of inflammatory... read more
Genomics and Pharmacogenomics of Sepsis: So Close and Yet So Far
Sapru et al. show in this issue of Critical Care that variants of thrombomodulin and the endothelial protein C receptor, but not protein C, are associated with mortality and organ dysfunction (ventilation-free and organ failure-free... read more
Biomarkers for Prediction of RRT in AKI
Acute kidney injury (AKI) frequently occurs in critically ill patients and often precipitates use of renal replacement therapy (RRT). However, the ideal circumstances for whether and when to start RRT remain unclear. We performed... read more
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis
Many sepsis survivors develop chronic critical illness (CCI) and are assumed to be immunosuppressed, but there is limited clinical evidence to support this. We sought to determine whether the incidence of secondary infections... read more
Do We Need New Trials of Procalcitonin-Guided Antibiotic Therapy?
Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect... read more
The EM Educator Series: Sepsis in the ED
These posts provide brief mini-cases followed by key questions to consider while working. The featured questions provide important learning points for those working with you, as well as vital items to consider in the evaluation... read more
